PF3D7_1446200

Summary

Gene Symbol: PF3D7_1446200
Description: M17 leucyl aminopeptidase
Alias: PF14_0439, M17 leucyl aminopeptidase
Species: Plasmodium falciparum 3D7

Top Publications

  1. Gardiner D, Trenholme K, Skinner Adams T, Stack C, Dalton J. Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. J Biol Chem. 2006;281:1741-5 pubmed
    ..Overexpression of genes in malaria parasites would have general application in the identification and validation of targets for antimalarial drugs. ..
  2. Stack C, Lowther J, Cunningham E, Donnelly S, Gardiner D, Trenholme K, et al. Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. J Biol Chem. 2007;282:2069-80 pubmed
    ..We have proposed that a Plasmodium falciparum M17 leucyl aminopeptidase (PfLAP) generates and regulates the internal pool of free amino acids and therefore represents a target ..
  3. McGowan S, Oellig C, Birru W, Caradoc Davies T, Stack C, Lowther J, et al. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc Natl Acad Sci U S A. 2010;107:2449-54 pubmed publisher
    ..Our detailed understanding of the PfA-M1 and PfA-M17 active sites now permits a rational approach in the development of a unique class of two-target and/or combination antimalarial therapy...