Gene Symbol: PF3D7_1311800
Description: M1-family alanyl aminopeptidase
Alias: MAL13P1.56, M1-family alanyl aminopeptidase
Species: Plasmodium falciparum 3D7
Florent I, Derhy Z, Allary M, Monsigny M, Mayer R, Schrevel J. A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages. Mol Biochem Parasitol. 1998;97:149-60 pubmed
Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002;125:1-10 pubmed
..The involvement of PfA-M1 in haemoglobin breakdown and erythrocyte reinvasion is discussed in light of the dual functions recently reported for several P. falciparum proteases. ..
Lal K, Prieto J, Bromley E, Sanderson S, Yates J, Wastling J, et al
. Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome. Proteomics. 2009;9:1142-51 pubmed publisher
..Previously uncharacterised proteins comprise the largest functional group of the microneme proteome and will include secreted proteins important to invasion. ..
Azimzadeh O, Sow C, G ze M, Nyalwidhe J, Florent I. Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole. Malar J. 2010;9:189 pubmed publisher
..These results provide insights on PfA-M1 topology regarding key compartments of the infected red blood cells that have important implications for the development of inhibitors targeting this plasmodial enzyme...
Ragheb D, Dalal S, Bompiani K, Ray W, Klemba M. Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism. J Biol Chem. 2011;286:27255-65 pubmed publisher
..They also suggest a second, distinct function for this enzyme in the parasite nucleus. ..
McGowan S, Oellig C, Birru W, Caradoc Davies T, Stack C, Lowther J, et al
. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc Natl Acad Sci U S A. 2010;107:2449-54 pubmed publisher
..Our detailed understanding of the PfA-M1 and PfA-M17 active sites now permits a rational approach in the development of a unique class of two-target and/or combination antimalarial therapy...