tumor necrosis factor

Summary

Gene Symbol: tumor necrosis factor
Description: tumor necrosis factor
Alias: TNFa, TNF-a, TNF-alpha, cachectin, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2, tumor-necrosis factor
Species: pig

Top Publications

  1. pmc The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-alpha via inhibition of activating protein-1: an experimental study
    Ma Qing
    Department of Pediatric Cardiology, Aachen University Hospital, Aachen, Germany
    Crit Care 10:R57. 2006
  2. doi Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1
    Sakthivel Subramaniam
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, NE 68583, USA
    Virology 406:270-9. 2010
  3. doi Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs
    Vaclav Vobruba
    Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Exp Lung Res 39:1-8. 2013
  4. doi Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway
    Jun Hou
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Virus Res 167:106-11. 2012
  5. doi Amino acid residues in the non-structural protein 1 of porcine reproductive and respiratory syndrome virus involved in down-regulation of TNF-α expression in vitro and attenuation in vivo
    Sakthivel Subramaniam
    School of Veterinary Medicine and Biomedical Sciences and Nebraska Center for Virology, University of Nebraska Lincoln, NE 68583, USA
    Virology 432:241-9. 2012
  6. pmc CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α
    Elizabeth L Overman
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 7:e39935. 2012
  7. doi Peripheral tumor necrosis factor α regulation of adipose tissue metabolism and adipokine gene expression in neonatal pigs
    T G Ramsay
    Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, USDA ARS, BARC East, Beltsville, MD 20705, USA
    Vet Res Commun 37:1-10. 2013
  8. doi High-volume hemofiltration reduces the expression of myocardial tumor necrosis factor-alpha in septic shock pigs
    Chunmei Li
    Kidney Disease Center, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Artif Organs 37:196-202. 2013
  9. doi Trans-10, cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway
    Dong In Kim
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Br J Nutr 105:1329-36. 2011
  10. pmc Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina
    Bodil Gesslein
    Department of Ophthalmology, Lund University, Sweden
    Mol Vis 16:2317-27. 2010

Research Grants

Scientific Experts

  • V Vobruba
  • T G Ramsay
  • James Niemann
  • Chandrakant Tayade
  • Kwonil Jung
  • J Kobr
  • P Chardon
  • Sakthivel Subramaniam
  • Chunmei Li
  • Jun Hou
  • Elizabeth L Overman
  • Asit K Pattnaik
  • Lalit K Beura
  • Dong In Kim
  • Byungjoon Kwon
  • Fernando A Osorio
  • Bodil Gesslein
  • Cai Hong Ma
  • C J Kim
  • S Holm
  • Eli Kakiashvili
  • Rajaie Namas
  • Xiao Luo
  • Andreas Skyschally
  • Sofiane Hadjadj
  • Yaohong Zhu
  • Ma Qing
  • Xiuju Cheng
  • Jianghua Chen
  • Ping Zhang
  • Lianghai Wang
  • Hexiao Zhang
  • Wen hai Feng
  • Adam J Moeser
  • Weiyong He
  • Jean E Rivier
  • Eui Man Jung
  • Mhan Pyo Yang
  • Keun Hwa Kim
  • Ji Houn Kang
  • Eui Bae Jeung
  • Sung Soo Kim
  • Lotta Gustafsson
  • Gisela Håkansson
  • Charles A Kuszynski
  • Yuan Chen
  • Li Li
  • Wei Sha
  • Qing Yuan Sun
  • Li ying Yan
  • Jie Qiao
  • Malin Malmsjo
  • Per Ekstrom
  • Matthew R Rosengart
  • V P Kouri
  • A Indahl
  • C Yang
  • Derek Barclay
  • Hernando Gomez
  • Timothy R Billiar
  • Rong Xin Liu
  • Gilles Clermont
  • T Archbold
  • Romy Seth
  • Andres Torres
  • Hui Xia Li
  • Ori D Rotstein
  • Zong Song Wu
  • Linda Hermus
  • Michael R Pinsky
  • Faiza Waheed
  • Lisa Gordon
  • M Z Fan
  • Y T Konttinen
  • Andrew Peitzman
  • Z Mackiewicz
  • Hyung Kook Kim
  • Ying Juan Yang
  • Juan Carlos Puyana
  • Pam Speight
  • Gong She Yang
  • Ali Ghuma
  • J Kovacs-Nolan
  • Sven Zenker
  • Monika Lodyga
  • J Salo
  • Katalin Szaszi
  • Y Mine
  • Andras Kapus
  • Ruben Zamora

Detail Information

Publications29

  1. pmc The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-alpha via inhibition of activating protein-1: an experimental study
    Ma Qing
    Department of Pediatric Cardiology, Aachen University Hospital, Aachen, Germany
    Crit Care 10:R57. 2006
    ....
  2. doi Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1
    Sakthivel Subramaniam
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, NE 68583, USA
    Virology 406:270-9. 2010
    ..These findings reveal one of the important mechanisms underlying the innate immune evasion by PRRSV during infection...
  3. doi Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs
    Vaclav Vobruba
    Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Exp Lung Res 39:1-8. 2013
    ..Production of TNF-α increased significantly in group III during the second and third hour (P = .01). Concentration of MIP-1β was significantly increased in groups II and III after the first hour (P = .012 and P = .008, respectively)...
  4. doi Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway
    Jun Hou
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Virus Res 167:106-11. 2012
    ..Here, the ability of the highly pathogenic strains (HV and JX) to induce tumor necrosis factor alpha (TNF-α) was studied...
  5. doi Amino acid residues in the non-structural protein 1 of porcine reproductive and respiratory syndrome virus involved in down-regulation of TNF-α expression in vitro and attenuation in vivo
    Sakthivel Subramaniam
    School of Veterinary Medicine and Biomedical Sciences and Nebraska Center for Virology, University of Nebraska Lincoln, NE 68583, USA
    Virology 432:241-9. 2012
    Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses tumor necrosis factor-alpha (TNF-α) production at both transcriptional and post-transcriptional levels by its non-structural proteins 1α and 1β (Nsp1α and Nsp1β)...
  6. pmc CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α
    Elizabeth L Overman
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 7:e39935. 2012
    ..Utilizing a porcine ex vivo intestinal model, the aim of this study was to investigate the mechanisms by which CRF mediates intestinal epithelial barrier disturbances...
  7. doi Peripheral tumor necrosis factor α regulation of adipose tissue metabolism and adipokine gene expression in neonatal pigs
    T G Ramsay
    Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, USDA ARS, BARC East, Beltsville, MD 20705, USA
    Vet Res Commun 37:1-10. 2013
    The neonatal pig is susceptible to stress and infection, conditions which favor tumor necrosis factor α (TNFα) secretion...
  8. doi High-volume hemofiltration reduces the expression of myocardial tumor necrosis factor-alpha in septic shock pigs
    Chunmei Li
    Kidney Disease Center, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Artif Organs 37:196-202. 2013
    Increasing evidence indicates that the expression of tumor necrosis factor-α (TNF-α) in myocardium correlates with the severity of cardiac dysfunction in septic shock...
  9. doi Trans-10, cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway
    Dong In Kim
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Br J Nutr 105:1329-36. 2011
    ..These results suggest that t10c12-CLA can modulate TNF-α production and NF-κB activation by a PPARγ-dependent pathway in porcine PBMC...
  10. pmc Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina
    Bodil Gesslein
    Department of Ophthalmology, Lund University, Sweden
    Mol Vis 16:2317-27. 2010
    ..The aim of the present study was to examine the role of tumor necrosis factor (TNF)α and its receptors (TNF-R1 and TNF-R2), especially considering the neuroretina and the retinal ..
  11. ncbi Signaling molecules for early detection of adverse interactions during mechanical ventilation in animal models
    J Kobr
    Department of Pediatrics, PICU, Charles University in Prague, Faculty of Medicine and Faculty Hospital in Pilsen, Czech Republic
    In Vivo 25:209-17. 2011
    ..The early identification of adverse interactions during mechanical ventilation, investigated by multiplexed immunoanalysis...
  12. pmc An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage
    Rajaie Namas
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 4:e8406. 2009
    ..Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental...
  13. pmc Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine
    James T Niemann
    The David Geffen School of Medicine at UCLA, University of California Los Angeles, CA, USA
    J Interferon Cytokine Res 29:749-58. 2009
    ..After 7 min of VF, resuscitation was performed as per guidelines. Plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 were measured 15 min after the start of resuscitation in all ..
  14. doi Pro-inflammatory, pleiotropic, and anti-inflammatory TNF-alpha, IL-6, and IL-10 in experimental porcine intervertebral disk degeneration
    S Holm
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg, Sweden
    Vet Pathol 46:1292-300. 2009
    The aim of this study was to check the balance between tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) in well-developed end-stage disk disease in the disk itself as well as in paradiskal spine...
  15. ncbi Beta-catenin protein utilized by Tumour necrosis factor-alpha in porcine preadipocytes to suppress differentiation
    Xiao Luo
    Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A and F University, 22 Xinong Road, Yangling, Shaanxi 712100, P R China
    BMB Rep 42:338-43. 2009
    ..Taken together, this study indicated that TNF-alpha inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes...
  16. doi L-cysteine supplementation attenuates local inflammation and restores gut homeostasis in a porcine model of colitis
    C J Kim
    Department of Food Science, University of Guelph, Guelph, ON, Canada N1G 2W1
    Biochim Biophys Acta 1790:1161-9. 2009
    ..L-cysteine was examined for its ability to reduce colitis symptoms and modulate local gene expression in a DSS-induced porcine model of colitis...
  17. ncbi Mapping and genetic organization of the TNF genes in the swine Mhc
    P Chardon
    INRA LRA, Jouy en Josas, France
    Immunogenetics 34:257-60. 1991
  18. ncbi The porcine tumor necrosis factor-encoding genes: sequence and comparative analysis
    P Kuhnert
    Institute of Veterinary Virology, University of Berne, Switzerland
    Gene 102:171-8. 1991
    We have cloned and sequenced a 10.22-kb fragment of the genomic locus of the porcine tumor necrosis factor-encoding genes, TNF-alpha and TNF-beta...
  19. pmc Gene sequence of porcine tumor necrosis factor alpha
    R T Drews
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia 30602
    Nucleic Acids Res 18:5564. 1990
  20. ncbi Porcine tumor necrosis factor alpha: cloning with the polymerase chain reaction and determination of the nucleotide sequence
    U Pauli
    Institute for Veterinary Virology, University of Berne, Switzerland
    Gene 81:185-91. 1989
    We have cloned the gene for the porcine tumor necrosis factor alpha (TNF-alpha) utilizing the polymerase chain reaction (PCR)...
  21. ncbi Sequence of the swine major histocompatibility complex region containing all non-classical class I genes
    P Chardon
    Laboratoire de Radiobiologie et Etude du Génome, INRA CEA, Jouy en Josas, France
    Tissue Antigens 57:55-65. 2001
    ..The centromeric part of the segment contained six class III genes including the three tumor necrosis factor genes, while the telomeric part contained three genes belonging to the class I region...
  22. ncbi Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation
    Chandrakant Tayade
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    J Immunol 176:148-56. 2006
    ....
  23. ncbi Stent implantation in coronary porcine arteries is associated with early activation of TNFalpha and TNFalpha receptor II expression
    Sofiane Hadjadj
    Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 192:25-32. 2007
    Inflammation present in restenosis after angioplasty is associated with production of cytokines such as tumor necrosis factor (TNFalpha)...
  24. ncbi Expression of tumor necrosis factor-alpha and cyclooxygenase-2 mRNA in porcine split-thickness wounds treated with epidermal growth factor by quantitative real-time PCR
    Kwonil Jung
    Department of Pharmacology and Toxicology, Institute of Bioscience and Biotechnology, Daewoong Pharmaceutical Co Ltd, 501 2, Samgye Ri, Pogok Myun, Kyounggi Do 449 814, Republic of Korea
    Res Vet Sci 82:344-8. 2007
    ..The effect of EGF on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2), levels during wound healing has not been reported...
  25. ncbi Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction
    Andreas Skyschally
    Institute of Pathophysiology, Center of Internal Medicine, University of Essen Medical School, Germany
    Circ Res 100:140-6. 2007
    ..ME-induced microinfarcts initiate an inflammatory reaction with increased tumor necrosis factor-alpha (TNF-alpha) expression, resulting in progressive contractile dysfunction...
  26. ncbi Morphometric analysis of proinflammatory cytokines in mammary glands of sows suggests an association between clinical mastitis and local production of IL-1beta, IL-6 and TNF-alpha
    Yaohong Zhu
    Division of Reproduction, Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden
    Vet Res 38:871-82. 2007
    ..The analyses of interleukin-1 beta (IL-1beta), IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) by immunohistochemistry revealed that the production of these proinflammatory cytokines ..
  27. pmc GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability
    Eli Kakiashvili
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and Department of Surgery, University of Toronto, Ontario M5B 1W8, Canada
    J Biol Chem 284:11454-66. 2009
    b>Tumor necrosis factor-alpha (TNF-alpha), an inflammatory cytokine, has been shown to activate the small GTPase Rho, but the underlying signaling mechanisms remained undefined...
  28. doi Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment
    Cai Hong Ma
    Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, People s Republic of China
    Fertil Steril 93:920-6. 2010
    To evaluate the effects of tumor necrosis factor-alpha (TNF-alpha) on porcine oocyte maturation, spindle dynamics, and chromosome alignment.
  29. ncbi Assignment of the porcine tumour necrosis factor alpha and beta genes to the chromosome region 7p11-q11 by in situ hybridization
    S Solinas
    Institut für Nutztierwissenschaften, Gruppe Züchtungsbiologie, Zurich, Switzerland
    Anim Genet 23:267-71. 1992
    The loci of the porcine tumour necrosis factor genes, alpha (TNFA) and beta (TNFB), have been chromosomally assigned by radioactive in situ hybridization...

Research Grants4

  1. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2007
    ..Preliminary studies have also demonstrated a dramatic increase in tumor necrosis factor-alpha (TNF) following resuscitation and reperfusion that is inversely related to the degree of cardiac ..