Gene Symbol: TP53
Description: tumor protein p53
Alias: P53, cellular tumor antigen p53, tumor suppressor p53
Species: pig

Top Publications

  1. Burr P, Argyle D, Reid S, Nasir L. Nucleotide sequence of the porcine p53 cDNA, and the detection of recombinant porcine p53 expressed in vitro with a variety of anti-p53 antibodies. Oncogene. 1999;18:5005-9 pubmed
    The cDNA of porcine p53 was cloned and sequenced by a reverse transcriptase polymerase chain reaction (RT - PCR) approach with primers based on regions of homology between all known p53 sequences...
  2. Sirotkin A, Ben o A, Tandlmajerov A, Va ek D. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell Prolif. 2012;45:9-14 pubmed publisher
    The aim of our in vitro experiments was to examine the role of transcription factor p53 and the metabolic hormone leptin, in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells, as well as ..
  3. Zou H, Jiang Z, Li R, Jia Y, Yang X, Ni Y, et al. p53 cooperates with Sp1 to regulate breed-dependent expression of glucocorticoid receptor in the liver of preweaning piglets. PLoS ONE. 2013;8:e70494 pubmed publisher
    ..Although p53 binding to GR promoter 1-9/10 did not differ between breeds, expression of p53 mRNA and protein, as well as its ..
  4. Dineva J, Wojtowicz A, Augustowska K, Vangelov I, Gregoraszczuk E, Ivanova M. Expression of atrial natriuretic peptide, progesterone, apoptosis-related proteins and caspase-3 in in vitro luteinized and leptin-treated porcine granulosa cells. Endocr Regul. 2007;41:11-8 pubmed
    Our aim was to examine the expression patterns of ANP, the rate of apoptosis bcl-2 and p53 expression and caspase-3 activity and progesterone (P) production in porcine granulosa cells (pGCs) stimulated in vitro for luteinization and ..
  5. Sirotkin A, Benco A, Tandlmajerova A, Vasicek D, Kotwica J, Darlak K, et al. Transcription factor p53 can regulate proliferation, apoptosis and secretory activity of luteinizing porcine ovarian granulosa cell cultured with and without ghrelin and FSH. Reproduction. 2008;136:611-8 pubmed publisher
    The aim of our in vitro experiments was to examine the role of transcription factor p53 in controlling the basic functions of ovarian cells and their response to hormonal treatments...
  6. Duran X, Vilahur G, Badimon L. Exogenous in vivo NO-donor treatment preserves p53 levels and protects vascular cells from apoptosis. Atherosclerosis. 2009;205:101-6 pubmed publisher
    ..Bcl2/bax ratio, phosphorylated-p53, cyclin-D2, casp-3, casp-8, and bax mRNA levels and protein expression were evaluated by real-time PCR and western ..
  7. Huang Y, Ding L, Li Z, Dai M, Zhao X, Li W, et al. Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. J Gen Virol. 2013;94:1807-17 pubmed publisher
    ..In this study, we investigated the regulation of p53 and p38 mitogen-activated protein kinases (MAPK) signalling pathways in the interaction of TGEV with host cells...
  8. Kim Y, Kim T, Kim M, Kim M, Kim H, Shim H. Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts. In Vitro Cell Dev Biol Anim. 2016;52:736-41 pubmed publisher
    b>Tumor suppressor p53 plays a critical role in the regulation of cell cycle and apoptosis in mammals. Mutations of p53 often cause various cancers...
  9. Oh H, Jin X, Kim J, Oh M, Pian X, Kim J, et al. Characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs. BMC Cell Biol. 2007;8:20 pubmed
    ..immortal MPF cells showed a transformed phenotype and possessed more frequent chromosomal abnormalities and loss of p53 regulatory function...

More Information


  1. Zhang H, Huang Y, Du Q, Luo X, Zhang L, Zhao X, et al. Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochem Biophys Res Commun. 2015;456:649-55 pubmed publisher
    ..Moreover, PPV infection activated p53 signaling, which was involved in the activation of apoptotic signaling induced by PPV infection via regulation of ..
  2. Rettenberger G, Klett C, Hameister H. Localization of the tumour protein, TP53, on porcine chromosome 12q12-q14. Anim Genet. 1993;24:307-9 pubmed
    A human cDNA probe of the tumour protein p53 (TP53) was used to localize the homologous porcine gene by in situ hybridization. The gene was mapped to chromosome 12q12-q14...
  3. Hussein M, Bedaiwy M, Falcone T. Analysis of apoptotic cell death, Bcl-2, and p53 protein expression in freshly fixed and cryopreserved ovarian tissue after exposure to warm ischemia. Fertil Steril. 2006;85 Suppl 1:1082-92 pubmed
    To evaluate the effect of ischemia time on the expression of Bcl-2 and p53 proteins on freshly fixed and cryopreserved-thawed ovarian tissue. Experimental study using porcine animal model...
  4. Kim S, Kim J, Moon J, Choi B, Kim T, Kim K, et al. Transcriptional alteration of p53 related processes as a key factor for skeletal muscle characteristics in Sus scrofa. Mol Cells. 2009;28:565-73 pubmed publisher above-mentioned categories included a large number of genes encoding proteins directly or indirectly involved in p53 pathway. Our results indicated a possible role of p53 to determine muscle characteristics between these two breeds.
  5. Sirotkin A, Dekanov√° P, Harrath A, Alwasel S, Vasicek D. Interrelationships between sirtuin 1 and transcription factors p53 and NF-?B (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell Tissue Res. 2014;358:627-32 pubmed publisher
    The roles of the mTOR system enzyme sirtuin 1 (SIRT1), the transcription factor p53 and the nuclear factor kappaB (NF-?B) and their interrelationships in the control of ovarian function have not been well studied...