Gene Symbol: SIRT1
Description: sirtuin 1
Alias: NAD-dependent protein deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin 1, sirtuin1
Species: pig

Top Publications

  1. Bai L, Pang W, Yang Y, Yang G. Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes. Mol Cell Biochem. 2008;307:129-40 pubmed
    b>Sirt1, a NAD(+)-dependent histone deacetylase, may regulate senescence, metabolism, and apoptosis...
  2. Shan T, Ren Y, Wu T, Liu C, Wang Y. Regulatory role of Sirt1 on the gene expression of fatty acid-binding protein 3 in cultured porcine adipocytes. J Cell Biochem. 2009;107:984-91 pubmed publisher
    To investigate whether Sirt1 could modulate fatty acid-binding protein 3 (FABP3), we treated porcine adipocytes either with the Sirt1 inhibitor nicotinamide (NAM), with the Sirt1 activator resveratrol (RES), or by knockdown of Sirt1 by ..
  3. Zu Y, Liu L, Lee M, Xu C, Liang Y, Man R, et al. SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res. 2010;106:1384-93 pubmed publisher
    ..b>SIRT1 is a conserved NAD(+)-dependent deacetylase possessing beneficial effects against aging-related diseases, despite ..
  4. Sirotkin A, Dekanov√° P, Harrath A, Alwasel S, Vasicek D. Interrelationships between sirtuin 1 and transcription factors p53 and NF-?B (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell Tissue Res. 2014;358:627-32 pubmed publisher
    The roles of the mTOR system enzyme sirtuin 1 (SIRT1), the transcription factor p53 and the nuclear factor kappaB (NF-?B) and their interrelationships in the control of ovarian function have not been well studied...
  5. Shan T, Wang Y, Wu T, Liu C, Guo J, Zhang Y, et al. Porcine sirtuin 1 gene clone, expression pattern, and regulation by resveratrol. J Anim Sci. 2009;87:895-904 pubmed publisher
    b>Sirtuin1 (Sirt1) is a NAD-dependent deacetylase that plays important roles in a variety of biological processes...
  6. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879-86 pubmed publisher
    ..b>Sirt1 is also a direct target of miR-199a and is responsible for downregulating prolyl hydroxylase 2, required for ..
  7. Shan T, Ren Y, Wang Y. Sirtuin 1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes. J Anim Sci. 2013;91:1247-54 pubmed publisher
    To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 ..
  8. Sato D, Itami N, Tasaki H, Takeo S, Kuwayama T, Iwata H. Relationship between mitochondrial DNA copy number and SIRT1 expression in porcine oocytes. PLoS ONE. 2014;9:e94488 pubmed publisher
    The present study assessed the effect of resveratrol on the expression of SIRT1 and mitochondrial quality and quantity in porcine oocytes...
  9. Zhao F, Zhao W, Ren S, Fu Y, Fang X, Wang X, et al. Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary. Anim Reprod Sci. 2014;151:34-41 pubmed publisher
    ..Sirtuin 1 (SIRT1) is a NAD(+)-dependent deacetylase, which is associated with apoptosis in several of cell types, but its exact ..

More Information


  1. Bai B, Liang Y, Xu C, Lee M, Xu A, Wu D, et al. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation. 2012;126:729-40 pubmed publisher
    ..Sirtuin-1 (SIRT1) is an NAD-dependent deacetylase possessing antiaging activities...