ryanodine receptor

Summary

Gene Symbol: ryanodine receptor
Description: ryanodine receptor 1 (skeletal)
Alias: CRC, RYR, RYR-1, calcium release channel, halothane, porcine stress syndrome, ryanodine receptor 1, skeletal muscle calcium release channel, skeletal muscle ryanodine receptor, skeletal muscle-type ryanodine receptor, type 1 ryanodine receptor
Species: pig

Top Publications

  1. ncbi Genomic organization and analysis of the 5' end of the porcine ryanodine receptor gene (ryr1)
    B Brenig
    Lehrstuhl für Molekulare Tierzucht, Veterinärmedizinische Fakultät Ludwig Maximilians Universität München, Germany
    FEBS Lett 298:277-9. 1992
  2. ncbi Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia
    K A Quane
    Department of Biochemistry, University College, Cork, Ireland
    Nat Genet 5:51-5. 1993
  3. pmc Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95)
    Tram Anh Ta
    UC Davis, Center for Children s Environmental Health, Davis, CA 95616, USA
    Neurotoxicology 28:770-9. 2007
  4. pmc Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density
    Liesbeth Biesmans
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    PLoS ONE 6:e25100. 2011
  5. ncbi Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin
    Bradley R Fruen
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biochemistry 44:278-84. 2005
  6. ncbi Association of calpastatin (CAST/MspI) polymorphism with meat quality parameters of fatteners and its interaction with RYR1 genotypes
    E Krzecio
    University of Podlasie, Chair of Pig Breeding and Meat Science, 08 110 Siedlce, 14 Prusa Str, Poland
    J Anim Breed Genet 122:251-8. 2005
  7. pmc Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem J 402:349-57. 2007
  8. ncbi The halothane gene, energy metabolism, adenosine monophosphate-activated protein kinase, and glycolysis in postmortem pig longissimus dorsi muscle
    Q W Shen
    Department of Animal Science, University of Wyoming, Laramie 82071, USA
    J Anim Sci 85:1054-61. 2007
  9. pmc Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia
    Dawei Jiang
    Libin Cardiovascular Institutes of Alberta, Department of Physiology, University of Calgary, Calgary, Alberta, Canada
    J Biol Chem 283:20813-20. 2008
  10. pmc FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel
    Razvan L Cornea
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:6128-33. 2009

Scientific Experts

  • Takashi Murayama
  • Razvan L Cornea
  • Bradley R Fruen
  • Liesbeth Biesmans
  • Jie Jiang
  • A Stinckens
  • Dawei Jiang
  • Edward M Balog
  • Q W Shen
  • David D Thomas
  • Tram Anh Ta
  • T Leeb
  • E Krzecio
  • B Brenig
  • Flávia Martins-Wess
  • Niall Macquaide
  • Godfrey L Smith
  • Frank R Heinzel
  • Virginie Bito
  • Karin R Sipido
  • Jin Zou
  • Priya Patel
  • Yubin Zhou
  • Yanyi Chen
  • Jenny J Yang
  • Simon Gruber
  • Michael Satzer
  • M Georges
  • T Luyten
  • N Buys
  • S De Smet
  • K Van den Maagdenberg
  • S Janssens
  • Florentin Nitu
  • Katherine Kohler
  • Wenqian Chen
  • Lin Zhang
  • S Schmoelzl
  • Ruiwu Wang
  • Peter P Jones
  • S R Wayne Chen
  • Huihui Kong
  • Bradley Fruen
  • Jianmin Xiao
  • W J Means
  • R J McCormick
  • Isaac N Pessah
  • K R Underwood
  • M Du
  • M Koćwin-Podsiadła
  • J Kurył
  • Florentin R Nitu
  • G Monin
  • Janet Schafer
  • G Wen
  • Cord Drogemuller
  • Bertram Brenig
  • Tosso Leeb
  • Rodja Voss-Nemitz
  • G Brem
  • M W Ledbetter
  • B Reinhart
  • I Harbitz
  • H Brinkmeier
  • K A Quane
  • Y Zhang
  • S de Leon
  • D H MacLennan
  • V K Khanna
  • J R Mickelson
  • C F Louis
  • J K Preiner
  • H S Chen
  • A K Browell
  • T H Fagerlund
  • B M Manning
  • B A Britt
  • C Doriguzzi
  • M S Phillips
  • H Ording
  • J M Healy
  • S Schmölzl
  • F J Couch
  • K E Keating
  • K Schappert
  • K Berg
  • S Kran
  • W Davies
  • L M Palmucci
  • J Fujii

Detail Information

Publications22

  1. ncbi Genomic organization and analysis of the 5' end of the porcine ryanodine receptor gene (ryr1)
    B Brenig
    Lehrstuhl für Molekulare Tierzucht, Veterinärmedizinische Fakultät Ludwig Maximilians Universität München, Germany
    FEBS Lett 298:277-9. 1992
    In this study we describe the isolation of genomic clones of the 5' region of the porcine ryanodine receptor gene, a candidate for malignant hyperthermia in pigs and humans...
  2. ncbi Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia
    K A Quane
    Department of Biochemistry, University College, Cork, Ireland
    Nat Genet 5:51-5. 1993
    ..CCD has recently been shown to be tightly linked to the ryanodine receptor gene (RYR1) and mutations in this gene are known to be present in MH...
  3. pmc Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95)
    Tram Anh Ta
    UC Davis, Center for Children s Environmental Health, Davis, CA 95616, USA
    Neurotoxicology 28:770-9. 2007
    ..inheriting one of >60 missense mutations within the highly regulated microsomal Ca(2+) channel known as ryanodine receptor type 1 (RyR1)...
  4. pmc Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density
    Liesbeth Biesmans
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    PLoS ONE 6:e25100. 2011
    In ventricular myocytes of large mammals, not all ryanodine receptor (RyR) clusters are associated with T-tubules (TTs); this fraction increases with cellular remodeling after myocardial infarction (MI).
  5. ncbi Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin
    Bradley R Fruen
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biochemistry 44:278-84. 2005
    Calmodulin (CaM) activates the skeletal muscle ryanodine receptor (RyR1) at nanomolar Ca(2+) concentrations but inhibits it at micromolar Ca(2+) concentrations, indicating that binding of Ca(2+) to CaM may provide a molecular switch for ..
  6. ncbi Association of calpastatin (CAST/MspI) polymorphism with meat quality parameters of fatteners and its interaction with RYR1 genotypes
    E Krzecio
    University of Podlasie, Chair of Pig Breeding and Meat Science, 08 110 Siedlce, 14 Prusa Str, Poland
    J Anim Breed Genet 122:251-8. 2005
    ..Significant interactions between CAST and RYR1 genotypes observed indicate that the quality of meat influenced by RYR1 genotype may be modified by the simultaneous influence of genotype as regards the CAST locus...
  7. pmc Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem J 402:349-57. 2007
    We have demonstrated recently that CICR (Ca2+-induced Ca2+ release) activity of RyR1 (ryanodine receptor 1) is held to a low level in mammalian skeletal muscle ('suppression' of the channel) and that this is largely caused by the ..
  8. ncbi The halothane gene, energy metabolism, adenosine monophosphate-activated protein kinase, and glycolysis in postmortem pig longissimus dorsi muscle
    Q W Shen
    Department of Animal Science, University of Wyoming, Laramie 82071, USA
    J Anim Sci 85:1054-61. 2007
    The presence of the halothane gene results in PSE meat. However, the exact mechanisms linking the halothane gene and the incidence of PSE meat remain unclear...
  9. pmc Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia
    Dawei Jiang
    Libin Cardiovascular Institutes of Alberta, Department of Physiology, University of Calgary, Calgary, Alberta, Canada
    J Biol Chem 283:20813-20. 2008
    Naturally occurring mutations in the skeletal muscle Ca(2+) release channel/ryanodine receptor RyR1 are linked to malignant hyperthermia (MH), a life-threatening complication of general anesthesia...
  10. pmc FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel
    Razvan L Cornea
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:6128-33. 2009
    Calmodulin (CaM) functions as a regulatory subunit of ryanodine receptor (RyR) channels, modulating channel activity in response to changing [Ca(2+)](i)...
  11. doi Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor
    A Stinckens
    Departement of Biosystems, KULeuven, 3001 Heverlee, Belgium
    Domest Anim Endocrinol 37:227-35. 2009
    ..Until now, QTN involved in muscle growth and/or ADG in pigs were identified in porcine ryanodine receptor 1 (RYR1), insulin-like growth factor-2 (IGF-2), and melanocortin-4 receptor (MC4R)...
  12. doi Site-specific modification of calmodulin Ca²(+) affinity tunes the skeletal muscle ryanodine receptor activation profile
    Jie Jiang
    Department of Chemistry, Georgia State University, Atlanta, 30303, USA
    Biochem J 432:89-99. 2010
    The skeletal muscle isoform of the ryanodine receptor Ca²(+)-release channel (RyR1) is regulated by Ca²(+) and CaM (calmodulin)...
  13. ncbi Construction of a 1.2-Mb BAC/PAC contig of the porcine gene RYR1 region on SSC 6q1.2 and comparative analysis with HSA 19q13.13
    Flávia Martins-Wess
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, Hannover, Germany
    Genomics 80:416-22. 2002
    ..2-Mb BAC/PAC contig of the ryanodine receptor-1 gene (RYR1) region on porcine chromosome (SSC) 6q1.2...
  14. ncbi The porcine skeletal muscle ryanodine receptor gene structure coding region 1 to 10614 harbouring 71 exons
    G Wen
    Institute of Veterinary Medicine, University of Goettingen, Germany
    Anim Genet 27:297-304. 1996
    The skeletal muscle ryanodine receptor (RYR1) belongs to a family of calcium release channels that are expressed in different tissues...
  15. ncbi DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg615----Cys615 mutation, associated with porcine malignant hyperthermia, in Norwegian landrace pigs
    I Harbitz
    Department of Biochemistry, Norwegian College of Veterinary Medicine, Oslo
    Anim Genet 23:395-402. 1992
    Porcine calcium release channel (CRC) cDNA from skeletal muscle has been cloned and sequenced. The deduced amino acid sequence showed 97% identity to the corresponding rabbit and human sequences...
  16. ncbi Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia
    J Fujii
    Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
    Science 253:448-51. 1991
    ..A single point mutation in the porcine gene for the skeletal muscle ryanodine receptor (ryr1) was found to be correlated with MH in five major breeds of lean, heavily muscled swine...
  17. ncbi Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11----q21 segment of chromosome 6
    I Harbitz
    Department of Biochemistry, Norwegian College of Veterinary Medicine, Oslo
    Genomics 8:243-8. 1990
    ..studies point to the possibility that malignant hyperthermia (MH) in pigs is caused by a defect in the calcium release channel (CRC) of skeletal muscle sarcoplasmic reticulum...
  18. ncbi Tissue distribution of ryanodine receptor isoforms and alleles determined by reverse transcription polymerase chain reaction
    M W Ledbetter
    Department of Biochemistry, University of Minnesota, St Paul 55108
    J Biol Chem 269:31544-51. 1994
    The tissue distribution of mRNA for ryanodine receptor (ryr) isoforms in various porcine tissues has been determined using the reverse transcription-polymerase chain reaction (RT-PCR)...
  19. ncbi A mutation in the human ryanodine receptor gene associated with central core disease
    Y Zhang
    Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, Ontario, Canada
    Nat Genet 5:46-50. 1993
    ..Since MH and CCD genes have been linked to the skeletal muscle ryanodine receptor (RYR1) gene, cDNA sequence analysis was used to search for a causal RYR1 mutation in a CCD ..
  20. ncbi Genomic organization of the porcine skeletal muscle ryanodine receptor (RYR1) gene coding region 4624 to 7929
    T Leeb
    Department of Molecular Animal Breeding, Max Planck Institute of Biochemistry, University of Munich, Martinsried, Federal Republic of Germany
    Genomics 18:349-54. 1993
    ..To study the genomic organization of the porcine skeletal muscle ryanodine receptor gene, we have isolated six genomic fragments spanning approximately 80 kb of chromosomal DNA...
  21. ncbi Regulation of tissue-specific expression of the skeletal muscle ryanodine receptor gene
    S Schmoelzl
    Institute of Veterinary Medicine, University of Gottingen, 37073 Gottingen, Federal Republic of Germany
    J Biol Chem 271:4763-9. 1996
    The ryanodine receptors (RYR) are a family of calcium release channels that are expressed in a variety of tissues. Three genes, i. e...
  22. ncbi Structural analysis of the porcine skeletal muscle ryanodine receptor gene coding region 3385 to 4623
    T Leeb
    Institute of Veterinary Medicine, University of Goettingen, Germany
    Mamm Genome 7:152-4. 1996