Gene Symbol: RELA
Description: RELA proto-oncogene, NF-kB subunit
Alias: transcription factor p65, NF-kappaB transcription factor p65 subunit, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
Species: pig
Products:     RELA

Top Publications

  1. Subramaniam S, Kwon B, Beura L, Kuszynski C, Pattnaik A, Osorio F. Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-?B and Sp1. Virology. 2010;406:270-9 pubmed publisher
    ..These findings reveal one of the important mechanisms underlying the innate immune evasion by PRRSV during infection...
  2. Palgrave C, Gilmour L, Lowden C, Lillico S, Mellencamp M, Whitelaw C. Species-specific variation in RELA underlies differences in NF-?B activity: a potential role in African swine fever pathogenesis. J Virol. 2011;85:6008-14 pubmed publisher
    ..from different pig species and the identification and initial in vitro characterization of polymorphic variation in RELA (p65; v-rel reticuloendotheliosis viral oncogene homolog A), the major component of the NF-?B transcription factor...
  3. Sirotkin A, Dekanov√° P, Harrath A, Alwasel S, Vasicek D. Interrelationships between sirtuin 1 and transcription factors p53 and NF-?B (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell Tissue Res. 2014;358:627-32 pubmed publisher
  4. Ding Z, An K, Xie L, Wu W, Zhang R, Wang D, et al. Transmissible gastroenteritis virus infection induces NF-?B activation through RLR-mediated signaling. Virology. 2017;507:170-178 pubmed publisher
    ..Furthermore, TGEV infection significantly upregulated mRNA expression of RIG-I and MDA5. Taken together, our results indicate that the RLR signaling pathway is involved in TGEV-induced inflammatory responses. ..
  5. Ross J, Ashworth M, Mathew D, Reagan P, Ritchey J, Hayashi K, et al. Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig. Reprod Biol Endocrinol. 2010;8:39 pubmed publisher
    ..Quantitative RT-PCR was utilized to demonstrate gene expression changes for NFKB1, RELA, TNFRSF11A, TLR4, NFKBIA and NFKBIB...
  6. Li H, Ma G, Gui D, Zhao S, Wang P, He K, et al. Characterization of the porcine p65 subunit of NF-?B and its association with virus antibody levels. Mol Immunol. 2011;48:914-23 pubmed publisher
  7. Chen L, Dong X, Zhao M, Shen H, Wang J, Pei J, et al. Classical swine fever virus failed to activate nuclear factor-kappa b signaling pathway both in vitro and in vivo. Virol J. 2012;9:293 pubmed publisher
    ..mobility shift assays (EMSA), NF-?B p65 translocation was detected using immunofluorescent staining, and p65/RelA and I?B? expression was measured by Western Blotting...
  8. Ruan J, Liu N, Ouyang H, Yang S, Li K. Spatiotemporal control of porcine p65RHD expression by advanced Tet-On system in PIEC cells helps regulate NF?B activity. Mol Biol Rep. 2014;41:1753-61 pubmed publisher
    ..The success of pp65RHD spatiotemporal expression system is helpful to regulate NF?B activity and conquer cell-mediated immunity and could be used for preparation of transgenic pig, contributing to xenotransplantation. ..
  9. Liu C, Wang Y, Zhang H, Cheng S, Charreyre C, Audonnet J, et al. Porcine coronin 1A contributes to nuclear factor-kappa B (NF-?B) inactivation during Haemophilus parasuis infection. PLoS ONE. 2014;9:e103904 pubmed publisher
    ..The results indicated that porcine Coro1A is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection. ..

More Information


  1. Su Q, Li L, Zhao J, Sun Y, Yang H. Effects of Trimetazidine on PDCD4/NF-?B/TNF-? Pathway in Coronary Microembolization. Cell Physiol Biochem. 2017;42:753-760 pubmed publisher
    ..05). TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-?B/ TNF-? pathway in cardiomyocytes. ..
  2. Lillico S, Proudfoot C, King T, Tan W, Zhang L, Mardjuki R, et al. Mammalian interspecies substitution of immune modulatory alleles by genome editing. Sci Rep. 2016;6:21645 pubmed publisher
    ..Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African ..