Gene Symbol: RBP4
Description: retinol binding protein 4
Alias: retinol-binding protein 4, PRBP, Plasma retinol-binding protein, RBP
Species: pig

Top Publications

  1. Trout W, McDonnell J, Kramer K, Baumbach G, Roberts R. The retinol-binding protein of the expanding pig blastocyst: molecular cloning and expression in trophectoderm and embryonic disc. Mol Endocrinol. 1991;5:1533-40 pubmed
    Retinol-binding protein (RBP) is a major secretory product of the porcine conceptus...
  2. Spötter A, Muller S, Hamann H, Distl O. Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines. Reprod Domest Anim. 2009;44:100-5 pubmed publisher
    ..diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4) with number of piglets born alive (NBA) in two German pig lines was studied...
  3. Blowe C, Boyette K, Ashwell M, Eisen E, Robison O, Cassady J. Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin. J Anim Breed Genet. 2006;123:389-95 pubmed
    ..1 marker loci coding for genes known to affect litter size: oestrogen receptor (ESR), retinol-binding protein 4 (RBP4) and follistatin (FS)...
  4. Zanotti G, Panzalorto M, Marcato A, Malpeli G, Folli C, Berni R. Structure of pig plasma retinol-binding protein at 1.65 A resolution. Acta Crystallogr D Biol Crystallogr. 1998;54:1049-52 pubmed
    The crystal structure of pig plasma retinol-binding protein (RBP) has been determined at 1.65 A resolution. The space group is P212121, with a = 45.81 (4), b = 53.14 (5), c = 72.97 (8) A and one protein molecule in the asymmetric unit...
  5. Chung H. Effects of SNPs using differentially expressed serum proteins at growth stages on average daily gain in pig. Mol Biol Rep. 2011;38:3777-85 pubmed publisher
    ..The identified SNPs may be helpful to understand different expression profiles of proteins at various growth stages as well as to explain genetic variations associated with ADG in pig industry. ..
  6. Sun Y, Zeng Y, Tang H, Fan X, Chen Q, Li H, et al. [Relationship of genetic polymorphism of PRLR and RBP4 genes with litter size traits in pig]. Yi Chuan. 2009;31:63-8 pubmed
    The polymorphism of prolactin receptor (PRLR) and retinol-binding protein 4 (RBP4) genes was detected by PCR-RFLP method, and the effects of PRLR and RBP4 genes on litter size traits in pig were analyzed by the least square analysis...
  7. Liu X, Chamba Y, Wang Q, Ling Y, Gu X, Wu K, et al. [Effects of multi-genes for reproductive traits in Tibet pig]. Yi Chuan. 2010;32:480-5 pubmed
    ..of estrogen receptor (ESR), follicle-stimulating hormone (FSHb), prolactin receptor (PRLR), and retinol binding protein 4 (RBP4) in Tibet pig and to analyze the effects of these variants and their combination genotypes on ..
  8. Cheng J, Song Z, Pu L, Yang H, Zheng J, Zhang Z, et al. Retinol binding protein 4 affects the adipogenesis of porcine preadipocytes through insulin signaling pathways. Biochem Cell Biol. 2013;91:236-43 pubmed publisher
    b>Retinol binding protein 4 (RBP4), a novel cytokine, is mainly secreted by hepatocytes and adipocytes...
  9. Harney J, Mirando M, Smith L, Bazer F. Retinol-binding protein: a major secretory product of the pig conceptus. Biol Reprod. 1990;42:523-32 pubmed
    ..9% and 90.9% homology with the first 33 amino acids of human and rabbit plasma retinol-binding protein (RBP), respectively...

More Information


  1. Mu oz M, Fern ndez A, Ovilo C, Mu oz G, Rodriguez C, Fern ndez A, et al. Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line. Genet Sel Evol. 2010;42:23 pubmed publisher
    The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes...
  2. Laliotis G, Marantidis A, Avdi M. Association of BF, RBP4, and ESR2 Genotypes with Litter Size in an Autochthonous Pig Population. Anim Biotechnol. 2017;28:138-143 pubmed publisher
    The aim of the present study was to determine any potential association of the BF, RBP4, and ESR2 genes with reproduction traits in an autochthonous Greek pig population...