PTGIS

Summary

Gene Symbol: PTGIS
Description: prostaglandin I2 (prostacyclin) synthase
Alias: CYP8A1, cytochrome P450 8A1
Species: pig

Top Publications

  1. pmc Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets
    Candice D Fike
    Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital, Vanderbilt, Nashville, TN 37232 0656, USA
    Am J Physiol Heart Circ Physiol 299:H1190-204. 2010
  2. doi Regulation of prostacyclin synthase expression and prostacyclin content in the pig endometrium
    E Morawska
    Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 78:2071-86. 2012
  3. pmc C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite
    Travis W Hein
    Scott and White Memorial Hospital, Department of Surgery, College of Medicine, Texas A and M Health Science Center, 702 Southwest H K Dodgen Loop, Temple, TX 76504, USA
    J Mol Cell Cardiol 47:196-202. 2009

Scientific Experts

Detail Information

Publications3

  1. pmc Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets
    Candice D Fike
    Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital, Vanderbilt, Nashville, TN 37232 0656, USA
    Am J Physiol Heart Circ Physiol 299:H1190-204. 2010
    ....
  2. doi Regulation of prostacyclin synthase expression and prostacyclin content in the pig endometrium
    E Morawska
    Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 78:2071-86. 2012
    ..Porcine conceptuses are important regulators of endometrial PGIS expression and PGI(2) release during the implantation period...
  3. pmc C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite
    Travis W Hein
    Scott and White Memorial Hospital, Department of Surgery, College of Medicine, Texas A and M Health Science Center, 702 Southwest H K Dodgen Loop, Temple, TX 76504, USA
    J Mol Cell Cardiol 47:196-202. 2009
    ..By impairing PGI(2)-S function, and thus PGI(2) release, CRP could promote endothelial dysfunction and participate in the development of coronary artery disease...

Research Grants13

  1. Chronic progressive hypoxia-induced pulmonary hypertension in newborns
    Candice D Fike; Fiscal Year: 2010
    ....
  2. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2004
    ..These studies should provide important information for improving treatment of infants with pulmonary hypertension. ..
  3. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2009
    ..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
  4. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2007
    ..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
  5. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2010
    ....
  6. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    TRAVIS HEIN; Fiscal Year: 2009
    ..Project Description Page 6 ..