PPIA

Summary

Gene Symbol: PPIA
Description: peptidylprolyl isomerase A
Alias: CYPA, peptidyl-prolyl cis-trans isomerase A, PPIase A, cyclophilin A, cyclosporin A-binding protein, rotamase A
Species: pig

Top Publications

  1. Fischer G, Wittmann Liebold B, Lang K, Kiefhaber T, Schmid F. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature. 1989;337:476-8 pubmed
    ..The activities of both PPIase and cyclophilin depend on a single sulphydryl group. At present it is unknown whether the inhibition of prolyl isomerase activity is related with the immunosuppressive action of CsA. ..
  2. Takahashi N, Hayano T, Suzuki M. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature. 1989;337:473-5 pubmed
    ..Thus we propose that the peptidyl-prolyl cis-trans isomerizing activity of PPIase may be involved in events, such as those occurring early in T-cell activation, that are suppressed by cyclosporin A. ..
  3. Palgrave C, Gilmour L, Lowden C, Lillico S, Mellencamp M, Whitelaw C. Species-specific variation in RELA underlies differences in NF-?B activity: a potential role in African swine fever pathogenesis. J Virol. 2011;85:6008-14 pubmed publisher
    ..We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon ASFV infection...