Gene Symbol: PNPLA2
Description: patatin like phospholipase domain containing 2
Alias: ATGL, patatin-like phospholipase domain-containing protein 2, adipose triglyceride lipase
Species: pig

Top Publications

  1. Chen J, Dai L, Xu N, Xiong Y, Jiang S. Assignment of the patatin-like phospholipase domain containing 2 gene (PNPLA2) to porcine chromosome 2p17 with radiation hybrids. Cytogenet Genome Res. 2006;112:342G pubmed
  2. Shan T, Wang Y, Wu T, Guo J, Liu J, Feng J, et al. Porcine adipose triglyceride lipase complementary deoxyribonucleic acid clone, expression pattern, and regulation by resveratrol. J Anim Sci. 2008;86:1781-8 pubmed publisher
    b>Adipose triglyceride lipase (ATGL) was recently identified and described as a major novel triglyceride lipase in animals...
  3. Li Y, Zheng X, Liu B, Yang G. Regulation of ATGL expression mediated by leptin in vitro in porcine adipocyte lipolysis. Mol Cell Biochem. 2010;333:121-8 pubmed publisher
    b>Adipose triglyceride lipase (ATGL), as an adipose-enriched protein, is able to hydrolyze triglycerides and plays an important part in triglyceride lipolysis of fat tissue...
  4. Dai L, Xiong Y, Jiang S, Chen J. Molecular characterization and association analysis of porcine adipose triglyceride lipase (PNPLA2) gene. Mol Biol Rep. 2011;38:921-7 pubmed publisher
    The adipose triglyceride lipase (PNPLA2, also known as ATGL) is a novel triacylglycerol (TG) lipase which specifically removes the first fatty acid from the triglyceride molecule generating free fatty acid and diglyceride (DG) in ..
  5. Shan T, Ren Y, Wang Y. Sirtuin 1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes. J Anim Sci. 2013;91:1247-54 pubmed publisher
    To investigate whether sirtuin 1 (Sirt1) could affect the transcriptional expression of the adipose triglyceride lipase (ATGL) gene, we treated porcine adipocytes with the general Sirt1 activator resveratrol (RES) with the Sirt1 ..
  6. Dai L, Chu X, Lu F, Xu R. Detection of four polymorphisms in 5' upstream region of PNPLA2 gene and their associations with economic traits in pigs. Mol Biol Rep. 2016;43:1305-1313 pubmed
    As an important triglyceride hydrolase in mammalian cells, patatin-like phospholipase domain-containing 2 (PNPLA2) predominantly performs the first step in triglyceride hydrolysis...
  7. Deiuliis J, Shin J, Bae D, Azain M, Barb R, Lee K. Developmental, hormonal, and nutritional regulation of porcine adipose triglyceride lipase (ATGL). Lipids. 2008;43:215-25 pubmed publisher
    b>Adipose triglyceride lipase (ATGL) is a newly identified lipase. We report for the first time the porcine ATGL sequence and characterize ATGL gene and protein expression in vitro and in vivo...