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| NOS3SummaryGene Symbol: NOS3 Description: nitric oxide synthase 3 (endothelial cell) Alias: EC-NOS, NOSIII, cNOS, eNOS, NOS type III, constitutive NOS, endothelial NOS, nitric oxide synthase, endothelial Species: pig Publications Molecular cloning, characterization and expression of a nitric oxide synthase from porcine pulmonary artery endothelial cellsJ Zhang Department of Medicine, University of Florida, Gainesville, USA Comp Biochem Physiol B Biochem Mol Biol 116:485-91 Dopamine D2-receptor-mediated increase in vascular and endothelial NOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in vitroGail J Pyne Geithman Department of Neurology, University of Cincinnati, 3125 Eden Avenue, 2324 Vontz Center, Cincinnati, OH 45267 0536, USA Neurocrit Care 10:225-31 Effects of chronic nitric oxide synthase inhibition on endothelium-dependent and -independent relaxation in arteries that perfuse skeletal muscle of swineS C Newcomer Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA Endothelium 15:17-31 Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysisBiljana Musicki Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA J Sex Med 5:552-61 Expression and cellular distribution of NADPH-diaphorase and nitric oxide synthases in the porcine uterus during early pregnancyAneta Andronowska Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland Folia Histochem Cytobiol 45:375-80 Genomic changes in regenerated porcine coronary arterial endothelial cellsMary Y K Lee Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong Arterioscler Thromb Vasc Biol 27:2443-9 Cloning and functional analysis of the swine eNOS promoterKimberly M Shontz Columbus Children s Research Institute, Columbus Children s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA DNA Seq 19:62-7 Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cellsChunying Li Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA Vascul Pharmacol 47:257-64 Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aortaJeffrey A LaMack Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA Atherosclerosis 195:e35-41 Glomerular eNOS gene expression during postnatal maturation and AT1 receptor inhibitionBrian Ratliff Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA Pediatr Nephrol 22:1135-42 | Scientific Experts
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Publications
Molecular cloning, characterization and expression of a nitric oxide synthase from porcine pulmonary artery endothelial cellsJ Zhang
Department of Medicine, University of Florida, Gainesville, USA
Comp Biochem Physiol B Biochem Mol Biol 116:485-91
Department of Medicine, University of Florida, Gainesville, USA
Comp Biochem Physiol B Biochem Mol Biol 116:485-91
..The molecular weight of porcine ecNOS mRNA was estimated to be 4.7 kb by Northern blot analysis, similar to human ecNOS mRNA. This suggests that porcine ecNOS is similar to human ecNOS in deduced amino acid sequence and structure...
Dopamine D2-receptor-mediated increase in vascular and endothelial NOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in vitroGail J Pyne Geithman
Department of Neurology, University of Cincinnati, 3125 Eden Avenue, 2324 Vontz Center, Cincinnati, OH 45267 0536, USA
Neurocrit Care 10:225-31
Department of Neurology, University of Cincinnati, 3125 Eden Avenue, 2324 Vontz Center, Cincinnati, OH 45267 0536, USA
Neurocrit Care 10:225-31
..05), but not by D(1) or D(3)-receptor antagonism. Both eNOS and iNOS expression were increased significantly in response to CSF(V) alone, and this was significantly enhanced ..
Effects of chronic nitric oxide synthase inhibition on endothelium-dependent and -independent relaxation in arteries that perfuse skeletal muscle of swineS C Newcomer
Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
Endothelium 15:17-31
Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
Endothelium 15:17-31
....
Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysisBiljana Musicki
Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
J Sex Med 5:552-61
Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
J Sex Med 5:552-61
..AIMS: We evaluated endothelial nitric oxide synthase (eNOS) interaction with its negative regulator caveolin-1 and eNOS uncoupling as molecular targets in the penis ..
Expression and cellular distribution of NADPH-diaphorase and nitric oxide synthases in the porcine uterus during early pregnancyAneta Andronowska
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
Folia Histochem Cytobiol 45:375-80
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
Folia Histochem Cytobiol 45:375-80
..The arterial endothelium expressed stronger NADPH-d staining compared with venous vessels. Immunoreactivity of eNOS was similar to NADPH-d staining but no optical differences in the intensity of staining were observed...
Genomic changes in regenerated porcine coronary arterial endothelial cellsMary Y K Lee
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong
Arterioscler Thromb Vasc Biol 27:2443-9
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong
Arterioscler Thromb Vasc Biol 27:2443-9
..A-FABP and MMP7 were induced by regeneration. RT-PCR revealed upregulation of A-FABP and downregulation of eNOS and TR...
Cloning and functional analysis of the swine eNOS promoterKimberly M Shontz
Columbus Children s Research Institute, Columbus Children s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
DNA Seq 19:62-7
Columbus Children s Research Institute, Columbus Children s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
DNA Seq 19:62-7
We have cloned the swine eNOS promoter and analyzed its function in newborn swine pulmonary artery endothelial cells (PAECs). Analysis of the 2...
Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cellsChunying Li
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Vascul Pharmacol 47:257-64
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Vascul Pharmacol 47:257-64
Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important modulator of vascular function...
Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aortaJeffrey A LaMack
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Atherosclerosis 195:e35-41
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Atherosclerosis 195:e35-41
..In the dark blue regions, eNOS was drastically downregulated and MCP-1 was upregulated relative to their expression in both the white and light ..
Glomerular eNOS gene expression during postnatal maturation and AT1 receptor inhibitionBrian Ratliff
Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA
Pediatr Nephrol 22:1135-42
Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA
Pediatr Nephrol 22:1135-42
..b>Endothelial NOS, eNOS, shows significant postnatal renal developmental regulation, perhaps mediated by Angiotensin II (AII)...
Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulationJudy L Aschner
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Physiol Lung Cell Mol Physiol 292:L1515-25
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Physiol Lung Cell Mol Physiol 292:L1515-25
Heat shock protein 90 (Hsp90) binding to endothelial nitric oxide synthase (eNOS) is an important step in eNOS activation. The conformational state of bound Hsp90 determines whether eNOS produces nitric oxide (NO) or superoxide (O(2)(*-))...
Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinaseEberhard Schulz
Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
Circulation 111:3473-80
Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
Circulation 111:3473-80
BACKGROUND: Estradiol activates endothelial nitric oxide synthase (eNOS) by mechanisms that involve estrogen receptor-alpha (ERalpha), protein kinase B/Akt, mitogen-activated protein kinases, and heat shock protein 90 (HSP90)...
Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expressionWeiping Fu
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
J Acquir Immune Defic Syndr 39:152-8
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
J Acquir Immune Defic Syndr 39:152-8
..was to determine the effects of the HIV PI ritonavir on vasomotor function and endothelial nitric oxide synthase (eNOS) expression. Porcine coronary artery rings were incubated with ritonavir for 24 hours...
Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenolsElad Anter
Evans Memorial Department of Medicine, The Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachussetts 02118, USA
J Biol Chem 279:46637-43
Evans Memorial Department of Medicine, The Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachussetts 02118, USA
J Biol Chem 279:46637-43
..This effect involved endothelial nitric-oxide synthase (eNOS) phosphorylation at Ser-1177 and dephosphorylation at Thr-495, consistent with increased eNOS activity...
The permissive role of endothelial NO in CO-induced cerebrovascular dilationEbrahim Barkoudah
Dept of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 287:H1459-65
Dept of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 287:H1459-65
..Such a requirement for NO could explain the endothelium dependency of CO-induced dilation in piglet pial arterioles...
Autoinhibitory domain fragment of endothelial NOS enhances pulmonary artery vasorelaxation by the NO-cGMP pathwayHanbo Hu
Research Service 151 VA Medical Center, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
Am J Physiol Lung Cell Mol Physiol 286:L1066-74
Research Service 151 VA Medical Center, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
Am J Physiol Lung Cell Mol Physiol 286:L1066-74
Catalytic activity of eNOS is regulated by multiple posttranscriptional mechanisms, including a 40-amino acid (604-643) autoinhibitory domain (AID) located in the reductase domain of the eNOS protein...
Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cellsEmeline Perrier
Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
Cardiovasc Res 82:133-42
Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
Cardiovasc Res 82:133-42
AIMS: The requirement of endothelial NO synthase (NOS3) calcium to produce NO is well described, although the effect of NO on intracellular calcium levels [Ca(2+)](i) is still confusing...