MX1

Summary

Gene Symbol: MX1
Description: MX dynamin like GTPase 1
Alias: MxA, interferon-induced GTP-binding protein Mx1, interferon-induced GTP-binding protein Mx1 pseudogene, myxoma resistance protein 1, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78, myxovirus protein, myxovirus resistance protein 1
Species: pig
Products:     MX1

Top Publications

  1. Nakajima E, Morozumi T, Tsukamoto K, Watanabe T, Plastow G, Mitsuhashi T. A naturally occurring variant of porcine Mx1 associated with increased susceptibility to influenza virus in vitro. Biochem Genet. 2007;45:11-24 pubmed
    b>Mx1 has been implicated in resistance to the influenza virus. We have now identified four alleles of the Mxl gene in domesticated breeds of pigs...
  2. Muller M, Winnacker E, Brem G. Molecular cloning of porcine Mx cDNAs: new members of a family of interferon-inducible proteins with homology to GTP-binding proteins. J Interferon Res. 1992;12:119-29 pubmed
    ..5%. The porcine Mx1 polypeptide is most closely related to human MxA (p78), murine Mx2, rat Mx2, and rat Mx3 proteins...
  3. Seago J, Hilton L, Reid E, Doceul V, Jeyatheesan J, Moganeradj K, et al. The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3. J Gen Virol. 2007;88:3002-6 pubmed
    ..Moreover, IFN-alpha stimulation of CSFV-infected cells induces the antiviral protein MxA, indicating that, as in BVDV-infected cells, the JAK/STAT pathway is not targeted for inhibition.
  4. Jung K, Chae C. Expression of Mx protein and interferon-alpha in pigs experimentally infected with swine influenza virus. Vet Pathol. 2006;43:161-7 pubmed
    ..8799, P < 0.05). These results indicated that Mx protein and IFN-alpha antigen were expressed in the lung from pigs experimentally infected with swine influenza virus, but their biological functions remain to be examined. ..
  5. Thomas A, Palm M, Broers A, Zezafoun H, Desmecht D. Genomic structure, promoter analysis, and expression of the porcine (Sus scrofa) Mx1 gene. Immunogenetics. 2006;58:383-9 pubmed
    Allelic polymorphisms at the mouse Mx1 locus affect the probability of survival after experimental influenzal disease, raising the possibility that marker-assisted selection using the homologous locus could improve the innate resistance ..
  6. Wu S, Bao W, Ju H, Chen G, Li B, Cheng J, et al. [Analysis of polymorphisms in exon 14 in porcine Mx1 gene and identification of new mutation points]. Yi Chuan. 2007;29:693-8 pubmed
    By the PCR-RFLP method, the polymorphisms of exon 14 of Mx1 gene were detected in 7 native and foreign pig breeds. Taken together with the analysis of restriction enzyme Hin6 I digestion, there were 6 genotypes and 3 alleles...
  7. Tungtrakoolsub P, Noda T, Morozumi T, Hamasima N, Kobayashi E, Ueda J, et al. Polymorphisms in the promoter region of the porcine antiviral MX1 and MX2 genes. Anim Genet. 2008;39:22-7 pubmed publisher
    The porcine MX1 and MX2 promoters were characterized in this study...
  8. Palm M, Garigliany M, Cornet F, Desmecht D. Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles. Vet Res. 2010;41:29 pubmed publisher
    ..Here we show that the porcine Mx1 protein (poMx1) inhibits replication of influenza A virus and we attempt to identify the step at which the viral ..
  9. He D, Zhang X, Liu K, Pang R, Zhao J, Zhou B, et al. In vitro inhibition of the replication of classical swine fever virus by porcine Mx1 protein. Antiviral Res. 2014;104:128-35 pubmed publisher
    ..Although Zhao et al. (2011) have reported that human MxA can inhibit CSFV replication, whether porcine Mx1 (poMx1) has anti-CSFV activity remains unknown...

More Information

Publications14

  1. Shi H, Fu Q, Ren Y, Wang D, Qiao J, Wang P, et al. Both foot-and-mouth disease virus and bovine viral diarrhea virus replication are inhibited by Mx1 protein originated from porcine. Anim Biotechnol. 2015;26:73-9 pubmed publisher
    b>Mx1 protein is I type interferons (IFNs)-induced 76-kDa guanosine triphosphatases (GTPases) that belong to the dynamin superfamily of large GTPases...
  2. Yuan B, Fang H, Shen C, Zheng C. Expression of porcine Mx1 with FMDV IRES enhances the antiviral activity against foot-and-mouth disease virus in PK-15 cells. Arch Virol. 2015;160:1989-99 pubmed publisher
    ..entry site (IRES) of FMDV was inserted between the promoter and open reading frame (ORF) of porcine myxovirus resistance protein 1 (poMx1)...
  3. Niu P, Shabir N, Khatun A, Seo B, Gu S, Lee S, et al. Effect of polymorphisms in the GBP1, Mx1 and CD163 genes on host responses to PRRSV infection in pigs. Vet Microbiol. 2016;182:187-95 pubmed publisher
    ..Guanylate-binding protein 1 (GBP1) and myxovirus resistance protein 1 (Mx1) are two important proteins belonging to the GTPase superfamily that have been previously ..
  4. Wang S, Liu W, Sargent C, Zhao S, Liu H, Liu X, et al. Effects of the polymorphisms of Mx1, BAT2 and CXCL12 genes on immunological traits in pigs. Mol Biol Rep. 2012;39:2417-27 pubmed publisher
    ..Polymorphisms in exon 13 of Mx1, intron 25 of BAT2 and intron 3 of CXCL12 were identified by sequencing, and the genotypes were analyzed by PCR-..
  5. Li Y, Liang S, Liu H, Sun Y, Kang L, Jiang Y. Identification of a short interspersed repetitive element insertion polymorphism in the porcine MX1 promoter associated with resistance to porcine reproductive and respiratory syndrome virus infection. Anim Genet. 2015;46:437-40 pubmed publisher
    ..that positive elements are present in the two promoter regions of -2713 to -2565 and -688 to -431 in the porcine MX1 gene...