Gene Symbol: MTOR
Description: mechanistic target of rapamycin kinase
Alias: FRAP1, serine/threonine-protein kinase mTOR, FK506 binding protein 12-rapamycin associated protein 1
Species: pig
Products:     MTOR

Top Publications

  1. Kong X, Tan B, Yin Y, Gao H, Li X, Jaeger L, et al. L-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells. J Nutr Biochem. 2012;23:1178-83 pubmed publisher
    ..The present study tested the hypothesis that Arg stimulates the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis in porcine conceptus trophectoderm (pTr2) cells...
  2. Suryawan A, Torrazza R, Gazzaneo M, Orellana R, Fiorotto M, El Kadi S, et al. Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways. Pediatr Res. 2012;71:324-31 pubmed publisher
    Leucine (Leu) activates mammalian target of rapamycin (mTOR) to upregulate protein synthesis (PS). ..
  3. Zhu B, Zhou Y, Xu F, Shuai J, Li X, Fang W. Porcine circovirus type 2 induces autophagy via the AMPK/ERK/TSC2/mTOR signaling pathway in PK-15 cells. J Virol. 2012;86:12003-12 pubmed publisher
    ..signal-regulated kinase 1/2 (ERK1/2), the tumor suppressor protein TSC2, and the mammalian target of rapamycin (mTOR)...
  4. Yi D, Hou Y, Wang L, Ouyang W, Long M, Zhao D, et al. L-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK. Amino Acids. 2015;47:65-78 pubmed publisher
    ..This study tested the hypothesis that Gln enhances enterocyte growth via both mammalian target of rapamycin (mTOR) and AMP-activated kinase (AMPK) signaling pathways...
  5. Yang W, Wang Y, Wang Y, Zhang J, Zhang J, Lu C, et al. mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. Mol Reprod Dev. 2015;82:305-14 pubmed publisher
    Mammalian target of rapamycin (mTOR) is known to be involved in mammalian cell proliferation, while S-phase kinase-associated protein 2 (SKP2) plays a vital role in the cell cycle...
  6. Long B, Yin C, Fan Q, Yan G, Wang Z, Li X, et al. Global Liver Proteome Analysis Using iTRAQ Reveals AMPK-mTOR-Autophagy Signaling Is Altered by Intrauterine Growth Restriction in Newborn Piglets. J Proteome Res. 2016;15:1262-73 pubmed publisher
    ..Additionally, many significantly down-regulated proteins participated in the mTOR signaling pathway and the phagosome maturation signaling pathway...
  7. Liu Y, Wang X, Wu H, Chen S, Zhu H, Zhang J, et al. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. Am J Physiol Regul Integr Comp Physiol. 2016;311:R365-73 pubmed publisher
    ..In addition, glycine restored the phosphorylation of Akt, mammalian target of rapamycin (mTOR), eukaryotic initiation factor 4E binding protein 1 (4E-BP1), and Forkhead Box O 1 (FOXO1) in gastrocnemius or LD ..
  8. Yang H, Xiong X, Wang X, Yin Y. Mammalian Target of Rapamycin Signaling Pathway Changes with Intestinal Epithelial Cells Renewal Along Crypt-Villus Axis. Cell Physiol Biochem. 2016;39:751-9 pubmed publisher
    ..The mechanistic target of rapamycin (mTOR) signaling pathway involves in controlling various major processes by integrating intracellular and extracellular ..
  9. Wan X, Wang S, Xu J, Zhuang L, Xing K, Zhang M, et al. Dietary protein-induced hepatic IGF-1 secretion mediated by PPAR? activation. PLoS ONE. 2017;12:e0173174 pubmed publisher
    ..Moreover, the protein levels of IGF-1 and PPAR?, as well as the phosphorylation of mTOR, significantly increased in HepG2 cells under high AA concentrations...

More Information


  1. Wagner R, Martin K, Powell R, Rzucidlo E. Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR. Am J Physiol Cell Physiol. 2010;299:C119-27 pubmed publisher
    ..In conclusion, these findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb and mTORC1 and promotion of a differentiated VSMC phenotype...
  2. Gazzaneo M, Orellana R, Suryawan A, Tuckow A, Kimball S, Wilson F, et al. Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal. Pediatr Res. 2011;70:253-60 pubmed publisher
    ..Phosphorylation of tuberous sclerosis complex 2, proline-rich Akt substrate of 40 kD, mTOR, eukaryotic initiation factor 4E binding protein, and rp S6 kinase 1 increased in all tissues after feeding...
  3. Kim S, Min K, Kim N, Yoon J. Differential expression of programmed cell death on the follicular development in normal and miniature pig ovary. PLoS ONE. 2012;7:e46194 pubmed publisher
    ..cell death during follicular development in porcine, MAP1LC3A, B and other autophagy-associated genes (ATG5, mTOR, Beclin-1) were found to increase in normal pigs, while it decreased in miniature pigs...
  4. Kim J, Song G, Wu G, Gao H, Johnson G, Bazer F. Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway. Biol Reprod. 2013;88:113 pubmed publisher
    ..Furthermore, when Arg, Leu, and Gln were combined with siRNAs for either MTOR, RPTOR, or RICTOR, effects of those amino acids on proliferation of pTr cells were significantly inhibited...
  5. Lee H, Kim D, Kim M, Lee J, Hwang J, Lee H. The regulation of autophagy in porcine blastocysts: Regulation of PARylation-mediated autophagy via mammalian target of rapamycin complex 1 (mTORC1) signaling. Biochem Biophys Res Commun. 2016;473:899-906 pubmed publisher
    ..Therefore, these findings have significant implications for understanding the importance of autophagy regulation for successful in vitro production of porcine embryos. ..
  6. Arnaud Batista F, Peruchetti D, Abreu T, do Nascimento N, Malnic G, Fonteles M, et al. Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways. Biochim Biophys Acta. 2016;1860:1431-8 pubmed publisher
    ..The current results expand our understanding of the signal transduction pathways involved in the overall effect of UGN on renal sodium excretion. ..