MC4R

Summary

Gene Symbol: MC4R
Description: melanocortin 4 receptor
Alias: melanocortin receptor 4, MC4-R, melanocortin-4 receptor MC4R
Species: pig

Top Publications

  1. Bruun C, Jørgensen C, Nielsen V, Andersson L, Fredholm M. Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire. Anim Genet. 2006;37:359-62 pubmed
    Melanocortin 4 receptor (MC4R) is expressed in the appetite-regulating areas of the brain where it is central in the regulation of feed intake and energy balance...
  2. Kim K, Larsen N, Short T, Plastow G, Rothschild M. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome. 2000;11:131-5 pubmed
    ..The melanocortin-4 receptor gene (MC4R) has been implicated in the regulation of feeding behavior and body weight in humans and mice...
  3. D Andrea M, Pilla F, Giuffra E, Waddington D, Archibald A. Structural analysis and haplotype diversity in swine LEP and MC4R genes. J Anim Breed Genet. 2008;125:130-6 pubmed publisher
    ..Leptin (LEP) and melanocortin-4 receptor (MC4R) genes are involved in the energetic pathway and are obvious candidate genes for fatness...
  4. Barb C, Hausman G, Rekaya R, Lents C, Lkhagvadorj S, Qu L, et al. Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations. Physiol Genomics. 2010;41:254-68 pubmed publisher
    ..used to identify genes and pathways that responded to intracerebroventricular injection of melanocortin-4 receptor (MC4R) agonist [Nle(4), d-Phe(7)]-?-melanocyte stimulating hormone (NDP-MSH) in pigs homozygous for the missense mutation ..
  5. Pi rkowska K, Tyra M, Rogoz M, Ropka Molik K, Oczkowicz M, R zycki M. Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland. Meat Sci. 2010;85:297-301 pubmed publisher
    The melanocortin-4 receptor (MC4R) is involved in feed intake regulation...
  6. Chao Z, Wang F, Deng C, Wei L, Sun R, Liu H, et al. Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in DIV2 line. Mol Biol Rep. 2012;39:6329-35 pubmed publisher
    PCR-RFLP was used to analyze the polymorphisms of MC4R, LEP, H-FABP genes in a swine breed composite (DIV2) and 4 swine breeds (Yorkshire, Landrace, Meishan, Bamei)...
  7. Oczkowicz M, Mucha A, Tyra M, Ropka Molik K, Piórkowska K. Lack of the associations of the polymorphisms in IGF2, MC4R and GNAS genes with reproduction traits in pigs and imprinting analysis of IGF2 gene in ovary and cornus uteri. Reprod Domest Anim. 2013;48:562-8 pubmed publisher
    ..In our study, we investigated associations between polymorphisms in IGF2, GNAS and MC4R genes with reproductive traits of Polish Landrace and Large White pigs...
  8. Van den Broeke A, Aluwé M, Tuyttens F, Ampe B, Vanhaecke L, Wauters J, et al. An intervention study demonstrates effects of MC4R genotype on boar taint and performances of growing-finishing pigs. J Anim Sci. 2015;93:934-43 pubmed publisher
    The Asp298Asn polymorphism of the melanocortin-4 receptor (MC4R) in pigs is known to affect economically important traits such as growth rate and backfat thickness...
  9. Meidtner K, Wermter A, Hinney A, Remschmidt H, Hebebrand J, Fries R. Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs. Anim Genet. 2006;37:245-7 pubmed
    The melanocortin 4 receptor (MC4R) is a key factor in the regulation of energy balance and body weight. Hence it is a candidate for feed intake and energy homeostasis-related traits...
  10. Mu oz G, Alc zar E, Fern ndez A, Barrag n C, Carrasco A, de Pedro E, et al. Effects of porcine MC4R and LEPR polymorphisms, gender and Duroc sire line on economic traits in Duroc × Iberian crossbred pigs. Meat Sci. 2011;88:169-73 pubmed publisher
    Polymorphisms MC4R c.1426 A>G (p.Asp298Asn) and LEPR c.2002 C>T (p.Leu663Phe) have been associated in pigs with feed intake, growth and fatness...

Detail Information

Publications17

  1. Bruun C, Jørgensen C, Nielsen V, Andersson L, Fredholm M. Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire. Anim Genet. 2006;37:359-62 pubmed
    Melanocortin 4 receptor (MC4R) is expressed in the appetite-regulating areas of the brain where it is central in the regulation of feed intake and energy balance...
  2. Kim K, Larsen N, Short T, Plastow G, Rothschild M. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome. 2000;11:131-5 pubmed
    ..The melanocortin-4 receptor gene (MC4R) has been implicated in the regulation of feeding behavior and body weight in humans and mice...
  3. D Andrea M, Pilla F, Giuffra E, Waddington D, Archibald A. Structural analysis and haplotype diversity in swine LEP and MC4R genes. J Anim Breed Genet. 2008;125:130-6 pubmed publisher
    ..Leptin (LEP) and melanocortin-4 receptor (MC4R) genes are involved in the energetic pathway and are obvious candidate genes for fatness...
  4. Barb C, Hausman G, Rekaya R, Lents C, Lkhagvadorj S, Qu L, et al. Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations. Physiol Genomics. 2010;41:254-68 pubmed publisher
    ..used to identify genes and pathways that responded to intracerebroventricular injection of melanocortin-4 receptor (MC4R) agonist [Nle(4), d-Phe(7)]-?-melanocyte stimulating hormone (NDP-MSH) in pigs homozygous for the missense mutation ..
  5. Pi rkowska K, Tyra M, Rogoz M, Ropka Molik K, Oczkowicz M, R zycki M. Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland. Meat Sci. 2010;85:297-301 pubmed publisher
    The melanocortin-4 receptor (MC4R) is involved in feed intake regulation...
  6. Chao Z, Wang F, Deng C, Wei L, Sun R, Liu H, et al. Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in DIV2 line. Mol Biol Rep. 2012;39:6329-35 pubmed publisher
    PCR-RFLP was used to analyze the polymorphisms of MC4R, LEP, H-FABP genes in a swine breed composite (DIV2) and 4 swine breeds (Yorkshire, Landrace, Meishan, Bamei)...
  7. Oczkowicz M, Mucha A, Tyra M, Ropka Molik K, Piórkowska K. Lack of the associations of the polymorphisms in IGF2, MC4R and GNAS genes with reproduction traits in pigs and imprinting analysis of IGF2 gene in ovary and cornus uteri. Reprod Domest Anim. 2013;48:562-8 pubmed publisher
    ..In our study, we investigated associations between polymorphisms in IGF2, GNAS and MC4R genes with reproductive traits of Polish Landrace and Large White pigs...
  8. Van den Broeke A, Aluwé M, Tuyttens F, Ampe B, Vanhaecke L, Wauters J, et al. An intervention study demonstrates effects of MC4R genotype on boar taint and performances of growing-finishing pigs. J Anim Sci. 2015;93:934-43 pubmed publisher
    The Asp298Asn polymorphism of the melanocortin-4 receptor (MC4R) in pigs is known to affect economically important traits such as growth rate and backfat thickness...
  9. Meidtner K, Wermter A, Hinney A, Remschmidt H, Hebebrand J, Fries R. Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs. Anim Genet. 2006;37:245-7 pubmed
    The melanocortin 4 receptor (MC4R) is a key factor in the regulation of energy balance and body weight. Hence it is a candidate for feed intake and energy homeostasis-related traits...
  10. Mu oz G, Alc zar E, Fern ndez A, Barrag n C, Carrasco A, de Pedro E, et al. Effects of porcine MC4R and LEPR polymorphisms, gender and Duroc sire line on economic traits in Duroc × Iberian crossbred pigs. Meat Sci. 2011;88:169-73 pubmed publisher
    Polymorphisms MC4R c.1426 A>G (p.Asp298Asn) and LEPR c.2002 C>T (p.Leu663Phe) have been associated in pigs with feed intake, growth and fatness...
  11. Hirose K, Ito T, Fukawa K, Arakawa A, Mikawa S, Hayashi Y, et al. Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs. Anim Sci J. 2014;85:198-206 pubmed publisher
    We evaluated multiple effects of genetic variations of five candidate loci (LEP, LEPR, MC4R, PIK3C3 and VRTN) on four production traits (average daily weight gain (ADG); backfat thickness (BFT); loin eye muscle area (EMA); and ..
  12. Kim K, Lee J, Shin H, Choi B, Lee C, Kim J, et al. Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms with pig growth and fat deposition traits. Anim Genet. 2006;37:419-21 pubmed
    The aim of this study was to analyse the combined effect of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms on growth and fatness traits in Duroc pigs...
  13. Fan Z, Sartin J, Tao Y. Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs. Domest Anim Endocrinol. 2008;34:383-90 pubmed publisher
    The melanocortin-4 receptor (MC4R) is critical in regulating mammalian food intake and energy expenditure. Numerous mutations in the MC4R gene have been identified from obese humans...
  14. Fan B, Onteru S, Plastow G, Rothschild M. Detailed characterization of the porcine MC4R gene in relation to fatness and growth. Anim Genet. 2009;40:401-9 pubmed publisher
    In contrast to the human MC4R gene, where multiple variants have been described, several of which are associated with appetite and obesity, few MC4R variants have been reported in the pig...
  15. Davoli R, Braglia S, Valastro V, Annaratone C, Annarratone C, Comella M, et al. Analysis of MC4R polymorphism in Italian Large White and Italian Duroc pigs: association with carcass traits. Meat Sci. 2012;90:887-92 pubmed publisher
    The melanocortin-4 receptor (MC4R) gene codes for a G protein transmembrane receptor playing an important role in energy homeostasis control. In pig a single nucleotide polymorphism c...
  16. Stinckens A, Luyten T, Van den Maagdenberg K, Janssens S, De Smet S, Georges M, et al. Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor. Domest Anim Endocrinol. 2009;37:227-35 pubmed publisher
    ..in porcine ryanodine receptor 1 (RYR1), insulin-like growth factor-2 (IGF-2), and melanocortin-4 receptor (MC4R). Recently, a fourth possible QTN was found in porcine myostatin (MSTN)...
  17. Li C, Pan Y, Meng H, Wang Z, Huang X. [Distributions of polymorphism of ADD1, MC4R, H-FABP gene, associated with IMF and BF in 3 populations in pig]. Yi Chuan. 2006;28:159-64 pubmed
    ..We have known that polymorphism of H-FABP, MC4R and ADD1 gene associated relation with IMF or BF in recent research...