Gene Symbol: MBL1
Description: mannan-binding lectin (A)
Alias: MBL-A, MBL2, MBP-A, pMBP-28, mannose-binding protein A, 28 kDa mannan-binding protein monomeric subunit, Mannan-binding lectin A, Mannose-binding lectin A, mannose-binding lectin 2, mannose-binding lectin A
Storgaard P, Nielsen E, Andersen O, Skriver E, Mortensen H, Højrup P, et al
. Isolation and characterization of porcine mannan-binding proteins of different size and ultrastructure. Scand J Immunol. 1996;43:289-96 pubmed
..The results further suggested the presence of a third pMBP which copurified with pMBP-27 but this protein was not sequenced. ..
Lillie B, Hammermueller J, MacInnes J, Jacques M, Hayes M. Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis. Dev Comp Immunol. 2006;30:954-65 pubmed
..While human MBL-C, the product of the MBL2 gene, is known to bind various microorganisms, our studies in pigs provide the first direct evidence that MBL-A has ..
Juul Madsen H, Krogh Meibom T, Henryon M, Palaniyar N, Heegaard P, Purup S, et al
. Identification and characterization of porcine mannan-binding lectin A (pMBL-A), and determination of serum concentration heritability. Immunogenetics. 2006;58:129-37 pubmed
..8) but not in the Duroc breed (h (2)=0.15). These genetic differences may be useful in selecting breeding pigs for improved disease resistance. ..
Lillie B, Keirstead N, Squires E, Hayes M. Single-nucleotide polymorphisms in porcine mannan-binding lectin A. Immunogenetics. 2006;58:983-93 pubmed
The MBL1 and MBL2 genes encode mannan-binding lectins (MBL) A and C, respectively, that are collagenous lectins (collectins) produced mainly by the liver...
Lillie B, Keirstead N, Squires E, Hayes M. Gene polymorphisms associated with reduced hepatic expression of porcine mannan-binding lectin C. Dev Comp Immunol. 2007;31:830-46 pubmed
..lectin C (MBL-C) in pigs was not due to single-nucleotide polymorphisms (SNPs) in the coding region of pig MBL2. In these studies, we compared the 5' flanking regions of porcine MBL1 (1907 bp) and MBL2 (1880 bp) in normal and ..
Phatsara C, Jennen D, Ponsuksili S, Murani E, Tesfaye D, Schellander K, et al
. Molecular genetic analysis of porcine mannose-binding lectin genes, MBL1 and MBL2, and their association with complement activity. Int J Immunogenet. 2007;34:55-63 pubmed
..The two forms are encoded by two distinct genes named MBL1 and MBL2, which have been identified in many species including the pig...
Marklund L, Shi X, Tuggle C. Rapid communication: mapping of the Mannose-Binding Lectin 2 (MBL2) gene to pig chromosome 14. J Anim Sci. 2000;78:2992-3 pubmed
Juul Madsen H, Kjærup R, Toft C, Henryon M, Heegaard P, Berg P, et al
. Structural gene variants in the porcine mannose-binding lectin 1 (MBL1) gene are associated with low serum MBL-A concentrations. Immunogenetics. 2011;63:309-17 pubmed publisher
..The MBL1 and MBL2 genes encode MBL-A and MBL-C, respectively...