LIF

Summary

Gene Symbol: LIF
Description: leukemia inhibitory factor
Alias: leukemia inhibitory factor (cholinergic differentiation factor)
Species: pig

Top Publications

  1. doi Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs
    A Blitek
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 78:951-64. 2012
  2. doi Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway
    Alison J Thomson
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom
    Cell Reprogram 14:112-22. 2012
  3. doi Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs
    H C Lin
    College of Animal Science and Technology and Key Laboratory for Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, Beijing, China
    Mol Biol Rep 36:1833-8. 2009
  4. doi Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany
    Reprod Domest Anim 44:100-5. 2009
  5. doi Leukemia inhibitory factor is upregulated in coronary arteries of Ossabaw miniature swine after stent placement
    Pamela G Lloyd
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Coron Artery Dis 19:217-26. 2008
  6. ncbi Evidence of a new leukemia inhibitory factor-associated genetic marker for litter size in a synthetic pig line
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17 p, 30559 Hannover, Germany
    J Anim Sci 83:2264-70. 2005
  7. ncbi Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF
    A Spötter
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, D 30559 Hannover, Germany
    Cytogenet Cell Genet 93:87-90. 2001
  8. ncbi Complex conserved organization of the mammalian leukemia inhibitory factor gene: regulated expression of intracellular and extracellular cytokines
    B P Haines
    Department of Biochemistry, University of Adelaide, Australia
    J Immunol 162:4637-46. 1999
  9. ncbi Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig
    G Rettenberger
    Department of Medical Genetics, University of Ulm, D 89069 Ulm, Germany
    Mamm Genome 7:275-9. 1996
  10. ncbi Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein
    T A Willson
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Eur J Biochem 204:21-30. 1992

Scientific Experts

  • A Spötter
  • A Blitek
  • Alison J Thomson
  • H C Lin
  • Pamela G Lloyd
  • Linda Sutherland
  • Edward Mountjoy
  • Alexandra Bogerman
  • Tom C Freeman
  • Hadrien Pierart
  • Helen Murray
  • Stephen Meek
  • C Bruce A Whitelaw
  • Alan L Archibald
  • Alison Downing
  • Chiara Sartori
  • Richard Talbot
  • Tom Burdon
  • A G Wang
  • G F Liu
  • L J Kong
  • X F Wang
  • J L Fu
  • Michael Sturek
  • B P Haines
  • Eric A Mokelke
  • Jason M Edwards
  • Alexander J Sheehy
  • G Rettenberger
  • R Forrest
  • P D Rathjen
  • R B Voyle
  • T A Pelton
  • R Fries
  • J Bruch
  • A L Archibald
  • H Hameister
  • T A Willson
  • D Metcalf
  • N M Gough

Detail Information

Publications10

  1. doi Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs
    A Blitek
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 78:951-64. 2012
    ..We examined: (1) the expression profiles of leukemia inhibitory factor (LIF) and interleukin (IL)-6 mRNA and their protein content in the endometrium of cyclic and pregnant gilts on Days 10 ..
  2. doi Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway
    Alison J Thomson
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom
    Cell Reprogram 14:112-22. 2012
    ..Mouse embryonic stem cells (ESCs) respond to leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP)-mediated activity, whereas human ESCs depend upon Fibroblast growth factor (..
  3. doi Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs
    H C Lin
    College of Animal Science and Technology and Key Laboratory for Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, Beijing, China
    Mol Biol Rep 36:1833-8. 2009
    DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter size in Large White pigs...
  4. doi Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany
    Reprod Domest Anim 44:100-5. 2009
    The association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4) with number of piglets born alive (NBA) in two German pig lines was studied...
  5. doi Leukemia inhibitory factor is upregulated in coronary arteries of Ossabaw miniature swine after stent placement
    Pamela G Lloyd
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Coron Artery Dis 19:217-26. 2008
    Leukemia inhibitory factor (LIF), an IL-6 class cytokine, is reported to be antiatherosclerotic. Thus, we hypothesized that LIF expression might be altered during in-stent neointimal hyperplasia...
  6. ncbi Evidence of a new leukemia inhibitory factor-associated genetic marker for litter size in a synthetic pig line
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17 p, 30559 Hannover, Germany
    J Anim Sci 83:2264-70. 2005
    The association of a diallelic polymorphism in the leukemia inhibitory factor (LIF) gene with reproductive, growth, and carcass traits was studied in a German synthetic pig line...
  7. ncbi Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF
    A Spötter
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, D 30559 Hannover, Germany
    Cytogenet Cell Genet 93:87-90. 2001
    Leukemia inhibitory factor (LIF) is a pleiotropic cytokine involved in early conceptus development in pig. We isolated a PAC clone containing the porcine LIF gene and determined the complete DNA sequence of the gene, which spans about 6...
  8. ncbi Complex conserved organization of the mammalian leukemia inhibitory factor gene: regulated expression of intracellular and extracellular cytokines
    B P Haines
    Department of Biochemistry, University of Adelaide, Australia
    J Immunol 162:4637-46. 1999
    Leukemia inhibitory factor (LIF) is a member of the IL-6 family of pleiotropic cytokines, which are extensively involved in modulating hematopoiesis and immunity...
  9. ncbi Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig
    G Rettenberger
    Department of Medical Genetics, University of Ulm, D 89069 Ulm, Germany
    Mamm Genome 7:275-9. 1996
    Nineteen so-called type I-loci, including ACO2, ADRA2, CAST, CCK, CHAT, IGKC, IGLV, IL4, IL6, INHA, LIF, MX1, PTH, RBP2, TCRA, TCRB, TGFB2, TGFB3, and UOX have been mapped in the pig with an informative somatic cell hybrid panel...
  10. ncbi Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein
    T A Willson
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Eur J Biochem 204:21-30. 1992
    Leukaemia inhibitory factor (LIF) is a pleiotropic growth factor active in diverse cell systems in both the adult and the embryo. The LIF gene from a number of mammalian species is highly conserved...