LEP

Summary

Gene Symbol: LEP
Description: leptin
Alias: OBS, leptin, obese, obesity factor
Species: pig
Products:     LEP

Top Publications

  1. de Oliveira Peixoto J, Facioni Guimarães S, Sávio Lopes P, Menck Soares M, Vieira Pires A, Gualberto Barbosa M, et al. Associations of leptin gene polymorphisms with production traits in pigs. J Anim Breed Genet. 2006;123:378-83 pubmed
    The associations of leptin (LEP) gene polymorphisms C798T, T2411C, T3266G and T3469C with production traits were investigated in a F2 pig population produced by divergent crosses...
  2. D Andrea M, Pilla F, Giuffra E, Waddington D, Archibald A. Structural analysis and haplotype diversity in swine LEP and MC4R genes. J Anim Breed Genet. 2008;125:130-6 pubmed publisher
    ..b>Leptin (LEP) and melanocortin-4 receptor (MC4R) genes are involved in the energetic pathway and are obvious candidate ..
  3. Bouloumie A, Drexler H, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 1998;83:1059-66 pubmed
    The adipocyte-derived cytokine leptin is thought to play a key role in the control of satiety and energy expenditure...
  4. Smolinska N, Siawrys G, Kaminski T, Przala J. Leptin gene and protein expression in the trophoblast and uterine tissues during early pregnancy and the oestrous cycle of pigs. J Physiol Pharmacol. 2007;58:563-81 pubmed
    b>Leptin is a 16-kDa protein hormone encoded by the obese (ob) gene and acts on receptors in the hypothalamus to regulate food intake and energy balance...
  5. Smolinska N, Kaminski T, Siawrys G, Przala J. Expression of leptin and its receptor genes in the ovarian follicles of cycling and early pregnant pigs. Animal. 2013;7:109-17 pubmed publisher
    b>Leptin is a polypeptide hormone produced primarily by adipocytes. It has been implicated in the regulation of satiety and energy homeostasis...
  6. Sirotkin A, Ben o A, Tandlmajerov A, Va ek D. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell Prolif. 2012;45:9-14 pubmed publisher
    The aim of our in vitro experiments was to examine the role of transcription factor p53 and the metabolic hormone leptin, in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells, as well as ..
  7. McNeel R, Mersmann H. Nutritional deprivation reduces the transcripts for transcription factors and adipocyte-characteristic proteins in porcine adipocytes. J Nutr Biochem. 2000;11:139-46 pubmed
    ..of several adipocyte-characteristic proteins, fatty acid synthase, glucose transporter 4, lipoprotein lipase, leptin, and adipocyte fatty acid binding protein were also significantly reduced...
  8. Siawrys G, Smolinska N. In vitro effects of luteinizing hormone, progesterone and oestradiol-17? on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy. J Physiol Pharmacol. 2013;64:513-20 pubmed
    b>Leptin, the product of the ob gene, is involved in the control of ovarian functions...
  9. Perez Montarelo D, Fernandez A, Folch J, Pena R, Ovilo C, Rodriguez C, et al. Joint effects of porcine leptin and leptin receptor polymorphisms on productivity and quality traits. Anim Genet. 2012;43:805-9 pubmed publisher
    b>Leptin signalling plays a fundamental role in growth, fatness and body composition...
  10. Sasaki S, Clutter A, Pomp D. Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism. Mamm Genome. 1996;7:471-2 pubmed

Detail Information

Publications44

  1. de Oliveira Peixoto J, Facioni Guimarães S, Sávio Lopes P, Menck Soares M, Vieira Pires A, Gualberto Barbosa M, et al. Associations of leptin gene polymorphisms with production traits in pigs. J Anim Breed Genet. 2006;123:378-83 pubmed
    The associations of leptin (LEP) gene polymorphisms C798T, T2411C, T3266G and T3469C with production traits were investigated in a F2 pig population produced by divergent crosses...
  2. D Andrea M, Pilla F, Giuffra E, Waddington D, Archibald A. Structural analysis and haplotype diversity in swine LEP and MC4R genes. J Anim Breed Genet. 2008;125:130-6 pubmed publisher
    ..b>Leptin (LEP) and melanocortin-4 receptor (MC4R) genes are involved in the energetic pathway and are obvious candidate ..
  3. Bouloumie A, Drexler H, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 1998;83:1059-66 pubmed
    The adipocyte-derived cytokine leptin is thought to play a key role in the control of satiety and energy expenditure...
  4. Smolinska N, Siawrys G, Kaminski T, Przala J. Leptin gene and protein expression in the trophoblast and uterine tissues during early pregnancy and the oestrous cycle of pigs. J Physiol Pharmacol. 2007;58:563-81 pubmed
    b>Leptin is a 16-kDa protein hormone encoded by the obese (ob) gene and acts on receptors in the hypothalamus to regulate food intake and energy balance...
  5. Smolinska N, Kaminski T, Siawrys G, Przala J. Expression of leptin and its receptor genes in the ovarian follicles of cycling and early pregnant pigs. Animal. 2013;7:109-17 pubmed publisher
    b>Leptin is a polypeptide hormone produced primarily by adipocytes. It has been implicated in the regulation of satiety and energy homeostasis...
  6. Sirotkin A, Ben o A, Tandlmajerov A, Va ek D. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell Prolif. 2012;45:9-14 pubmed publisher
    The aim of our in vitro experiments was to examine the role of transcription factor p53 and the metabolic hormone leptin, in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells, as well as ..
  7. McNeel R, Mersmann H. Nutritional deprivation reduces the transcripts for transcription factors and adipocyte-characteristic proteins in porcine adipocytes. J Nutr Biochem. 2000;11:139-46 pubmed
    ..of several adipocyte-characteristic proteins, fatty acid synthase, glucose transporter 4, lipoprotein lipase, leptin, and adipocyte fatty acid binding protein were also significantly reduced...
  8. Siawrys G, Smolinska N. In vitro effects of luteinizing hormone, progesterone and oestradiol-17? on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy. J Physiol Pharmacol. 2013;64:513-20 pubmed
    b>Leptin, the product of the ob gene, is involved in the control of ovarian functions...
  9. Perez Montarelo D, Fernandez A, Folch J, Pena R, Ovilo C, Rodriguez C, et al. Joint effects of porcine leptin and leptin receptor polymorphisms on productivity and quality traits. Anim Genet. 2012;43:805-9 pubmed publisher
    b>Leptin signalling plays a fundamental role in growth, fatness and body composition...
  10. Sasaki S, Clutter A, Pomp D. Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism. Mamm Genome. 1996;7:471-2 pubmed
  11. De W, Ai rong Z, Yan L, Sheng yu X, Hai yan G, Yong Z. Effect of feeding allowance level on embryonic survival, IGF-1, insulin, GH, leptin and progesterone secretion in early pregnancy gilts. J Anim Physiol Anim Nutr (Berl). 2009;93:577-85 pubmed publisher
    ..Concentrations of insulin-like growth factor I (IGF)-1, insulin, growth harmone (GH), leptin and progesterone in serum and uterine flushings were determined by enzyme-linked immunosorbent assay...
  12. Liu D, Hu Y, Yang X, Liu Y, Wei S, Jiang Y. Identification and genetic effects of a novel polymorphism in the distal promoter region of porcine leptin gene. Mol Biol Rep. 2011;38:2051-7 pubmed publisher
    b>Leptin is a hormone expressed mainly in white adipose tissue...
  13. Silveira A, Antunes R, Almeida J, Braga T, Freitas P, Cesar A, et al. Obese gene polymorphism in Pietrain and Large White pigs after a divergent selection. Genet Mol Res. 2008;7:1217-22 pubmed
    The aim of the present study was to identify polymorphisms in the leptin gene of 112 pigs and compare the maternal and paternal lineage of Pietrain and Large White breeds that underwent a divergent selection for over 30 years...
  14. Cervantes M, Cota M, Arce N, Castillo G, Avelar E, Espinoza S, et al. Effect of heat stress on performance and expression of selected amino acid and glucose transporters, HSP90, leptin and ghrelin in growing pigs. J Therm Biol. 2016;59:69-76 pubmed publisher
    ..ambient temperature on expression of amino acid (b(0,+)AT, CAT1) and glucose (SGLT1, GLUT4) transporters, ghrelin, leptin and HSP90 was evaluated. Eighteen pigs (32...
  15. Kerr A, Kridli R, Khalaj K, Wessels J, Hahnel A, Tayade C. Expression of leptin and its long form receptor at the porcine maternal-fetal interface: contrasting healthy and arresting conceptus attachment sites during early and mid-pregnancy. Reprod Biol Endocrinol. 2014;12:91 pubmed publisher
    ..b>Leptin (LEP), a metabolic hormone, has also been implicated in the promotion of angiogenesis...
  16. Wang H, Fu J, Wang A. Expression of obesity gene and obesity gene long form receptor in endometrium of Yorkshire sows during embryo implantation. Mol Biol Rep. 2014;41:1597-606 pubmed publisher
    There is accumulating evidence that leptin may be directly involved in mammalian reproduction, however, the potential role of obesity gene/obesity gene long form receptor (ob/ob-Rb) system in porcine implantation is poorly understood...
  17. Gonzalez Bulnes A, Astiz S, Encinas T, Gonzalez Añover P, Perez Solana M, Sanchez Sanchez R, et al. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance. Peptides. 2012;37:290-3 pubmed publisher
    Patterns of leptin secretion during the estrous cycle and the possible relationship of changes in circulating leptin during the periovulatory period with ovarian function in sows of obese (Iberian breed) and lean genotype (Large White x ..
  18. Rago V, Aquila S, Guido C, Carpino A. Leptin and its receptor are expressed in the testis and in the epididymis of young and adult pigs. Anat Rec (Hoboken). 2009;292:736-45 pubmed publisher
    Recent studies indicated that leptin, a 16 kDa hormone, is a regulatory signal in human and rodent male reproduction...
  19. Pérez Montarelo D, Rodríguez M, Fernández A, Benítez R, García F, Silió L, et al. Haplotypic diversity of porcine LEP and LEPR genes involved in growth and fatness regulation. J Appl Genet. 2015;56:525-533 pubmed publisher
    ..The leptin (LEP) and its receptor (LEPR) porcine genes are involved in food intake and energy homeostasis, and polymorphisms ..
  20. Zhou J, Zhao R, Wei X, Xia D, Xu Q, Chen J. Developmental patterns of serum leptin levels, leptin gene expression in adipose tissue and Ob-Rb gene expression in hypothalamus of Erhualian and Large White pigs. Sci China C Life Sci. 2004;47:190-6 pubmed
    The present study was aimed to investigate the developmental patterns of leptin mRNA expression in dorsal subcutaneous adipose tissue and Ob-Rb mRNA expression in hypothalamus in pigs of different breeds and sexes...
  21. Mankowska M, Szydlowski M, Salamon S, Bartz M, Switonski M. Novel polymorphisms in porcine 3'UTR of the leptin gene, including a rare variant within target sequence for MIR-9 gene in Duroc breed, not associated with production traits. Anim Biotechnol. 2015;26:156-63 pubmed publisher
    The leptin gene (LEP) is considered as a functional candidate for production traits in livestock due to its crucial role in energy homeostasis...
  22. Kennes Y, Murphy B, Pothier F, Palin M. Characterization of swine leptin (LEP) polymorphisms and their association with production traits. Anim Genet. 2001;32:215-8 pubmed
    Four polymorphisms in the swine leptin (LEP) gene were characterized and evaluated for association with economically important production traits in Yorkshire, Landrace and Duroc pigs...
  23. Dixit V, Mielenz M, Taub D, Parvizi N. Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism. Endocrinology. 2003;144:5595-603 pubmed
    b>Leptin is a key mediator of signals regulating food intake and energy expenditure and exerts potent immunomodulatory effects...
  24. Payne G, Borbouse L, Kumar S, Neeb Z, Alloosh M, Sturek M, et al. Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Arterioscler Thromb Vasc Biol. 2010;30:1711-7 pubmed publisher
    ..The current study investigated whether PVAT-derived leptin impairs coronary vascular function via PKC-beta in MetS. ..
  25. McNeel R, Ding S, Smith E, Mersmann H. Effect of feed restriction on adipose tissue transcript concentrations in genetically lean and obese pigs. J Anim Sci. 2000;78:934-42 pubmed
    ..The adipose tissue glucose transporter 4, fatty acid synthase, and leptin transcript concentrations were greater (P < .05) in obese than in lean pigs...
  26. Perez Montarelo D, Fernandez A, Barragan C, Noguera J, Folch J, Rodríguez M, et al. Transcriptional Characterization of Porcine Leptin and Leptin Receptor Genes. PLoS ONE. 2013;8:e66398 pubmed publisher
    The leptin (LEP) and its receptor (LEPR) regulate food intake and energy balance through hypothalamic signaling. However, the LEP-LEPR axis seems to be more complex and its expression regulation has not been well described...
  27. Baratta M, Saleri R, Mainardi G, Valle D, Giustina A, Tamanini C. Leptin regulates GH gene expression and secretion and nitric oxide production in pig pituitary cells. Endocrinology. 2002;143:551-7 pubmed
    The aim of this study was to investigate the direct effect of leptin on GH gene expression and secretion and the role of nitric oxide as a possible mediator in pig anterior pituitary cells...
  28. Hirose K, Ito T, Fukawa K, Arakawa A, Mikawa S, Hayashi Y, et al. Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs. Anim Sci J. 2014;85:198-206 pubmed publisher
    We evaluated multiple effects of genetic variations of five candidate loci (LEP, LEPR, MC4R, PIK3C3 and VRTN) on four production traits (average daily weight gain (ADG); backfat thickness (BFT); loin eye muscle area (EMA); and ..
  29. Siawrys G, Kaminski T, Smolinska N, Przala J. Expression of leptin and long-form leptin-receptor proteins in porcine hypothalamus during oestrous cycle and pregnancy. Reprod Domest Anim. 2009;44:920-6 pubmed publisher
    In this study, we examined the levels of leptin and OB-Rb protein expression in the discrete areas of the porcine hypothalamus (mediobasal hypothalamus--MBH, pre-optic area--POA, stalk median eminence--SME) during mid- and late-luteal ..
  30. Govoni N, Galeati G, Castellani G, Tamanini C. Leptin concentrations in plasma and follicular fluid from prepubertal gilts as influenced by fasting, refeeding and insulin. Horm Metab Res. 2005;37:152-8 pubmed
    This study's aim was to examine whether fasting and refeeding would influence leptin levels in both plasma and follicular fluid from prepubertal gilts, and whether insulin affects leptin levels in fasting gilts...
  31. Di Giancamillo A, Rossi R, Vitari F, Pastorelli G, Corino C, Domeneghini C. Dietary conjugated linoleic acids decrease leptin in porcine adipose tissue. J Nutr. 2009;139:1867-72 pubmed publisher
    ..01) than in CTR pig. Immunohistochemistry revealed that leptin (Ob) expression was lower (P = 0...
  32. Gregoraszczuk E, Ptak A. In vitro effect of leptin on growth hormone (GH)- and insulin-like growth factor-I (IGF-I)-stimulated progesterone secretion and apoptosis in developing and mature corpora lutea of pig ovaries. J Reprod Dev. 2005;51:727-33 pubmed
    This study was designed to determine whether leptin modulates growth hormone (GH)- and insulin like growth factor-I (IGF-I)-stimulated progesterone (P4) production by corpora lutea (CL)...
  33. Ramsay T, Yan X, Morrison C. The obesity gene in swine: sequence and expression of porcine leptin. J Anim Sci. 1998;76:484-90 pubmed
    b>Leptin is a 16-kDa protein secreted by adipocytes that has been proposed to regulate feed intake in mice, rats, and humans. The present study was designed to characterize porcine leptin structure and expression...
  34. Torres Rovira L, Tarrade A, Astiz S, Mourier E, Perez Solana M, de la Cruz P, et al. Sex and breed-dependent organ development and metabolic responses in foetuses from lean and obese/leptin resistant swine. PLoS ONE. 2013;8:e66728 pubmed publisher
    ..Thus, at Day 62 of pregnancy, swine foetuses from an obese breed with leptin resistance (Iberian breed) were compared to lean crossbred foetuses (25% Large White ×25% Landrace ×50% ..
  35. Chao Z, Wang F, Deng C, Wei L, Sun R, Liu H, et al. Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in DIV2 line. Mol Biol Rep. 2012;39:6329-35 pubmed publisher
    PCR-RFLP was used to analyze the polymorphisms of MC4R, LEP, H-FABP genes in a swine breed composite (DIV2) and 4 swine breeds (Yorkshire, Landrace, Meishan, Bamei)...
  36. Siawrys G, Smolinska N. Direct in vitro effect of LH and steroids on leptin gene expression and leptin secretion by porcine luteal cells during the mid-luteal phase of the estrous cycle. Reprod Biol. 2012;12:317-23 pubmed publisher
    b>Leptin, the product of the ob gene, is implicated in the control of reproductive functions in different species. Leptin transcript and protein are present in several tissues including adipose tissue and corpus luteum...
  37. Richards M, Caperna T, Elsasser T, Ashwell C, McMurtry J. Design and application of a polyclonal peptide antiserum for the universal detection of leptin protein. J Biochem Biophys Methods. 2000;45:147-56 pubmed
    ..a synthetic 15 amino acid peptide (QRVTGLDFIPGLHPV) derived from the coding sequence reported for the porcine leptin gene (GenBank Accession No. U59894)...
  38. Smolinska N, Kaminski T, Siawrys G, Przala J. Leptin gene and protein expression in the ovary during the oestrous cycle and early pregnancy in pigs. Reprod Domest Anim. 2010;45:e174-83 pubmed publisher
    b>Leptin, the product of the obese gene, is the hormone originally identified in adipocytes. It is involved in the control of satiety and energy metabolism...
  39. Craig J, Zhu H, Dyce P, Petrik J, Li J. Leptin enhances oocyte nuclear and cytoplasmic maturation via the mitogen-activated protein kinase pathway. Endocrinology. 2004;145:5355-63 pubmed
    Recent studies have suggested that leptin has a central role in female reproduction, including ovarian function...
  40. Jiang Z, Gibson J. Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds. Mamm Genome. 1999;10:191-3 pubmed
  41. Moreira F, Gheller S, Mondadori R, Varela Junior A, Corcini C, Lucia T. Presence of leptin and its receptor in the hypothalamus, uterus and ovaries of Swine females culled with distinct ovarian statuses and parities. Reprod Domest Anim. 2014;49:1074-8 pubmed publisher
    b>Leptin acts on energy metabolism, affecting reproductive functions through activation of its receptors in the brain and in reproductive organs...
  42. Neuenschwander S, Rettenberger G, Meijerink E, Jörg H, Stranzinger G. Partial characterization of porcine obesity gene (OBS) and its localization to chromosome 18 by somatic cell hybrids. Anim Genet. 1996;27:275-8 pubmed
    Degenerate primers based on human and mouse obesity gene (OBS) sequencing data were used in the reverse transcriptase-polymerase chain reaction (RT-PCR) of total RNA from pig white adipose tissue...
  43. Smolinska N, Przala J, Kaminski T, Siawrys G, Gajewska A, Kochman K, et al. Leptin gene expression in the hypothalamus and pituitary of pregnant pigs. Neuro Endocrinol Lett. 2004;25:191-5 pubmed
    b>Leptin, the 16-kDa peptide hormone product of the ob gene, is a regulatory hormone secreted mainly by adipose tissue...
  44. Stachowiak M, Mackowski M, Madeja Z, Szydlowski M, Buszka A, Kaczmarek P, et al. Polymorphism of the porcine leptin gene promoter and analysis of its association with gene expression and fatness traits. Biochem Genet. 2007;45:245-53 pubmed
    We describe for the first time a 245 bp fragment of the porcine leptin gene promoter in the proximity of the transcription start site. Altogether, 720 pigs were screened with the PCR-SSCP technique for polymorphism in this region...