IL4

Summary

Gene Symbol: IL4
Description: interleukin 4
Alias: interleukin-4, B-cell stimulatory factor 1, BSF-1, IL-4, lymphocyte stimulatory factor 1
Species: pig

Top Publications

  1. ncbi Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages
    Y Zhou
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul
    J Leukoc Biol 56:507-13. 1994
  2. ncbi IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway
    John F Grehan
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 175:1903-10. 2005
  3. pmc Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury
    Agustin P Dalmasso
    From the Departments of Surgery
    J Biol Chem 289:838-47. 2014
  4. doi Species specialization in cytokine biology: is interleukin-4 central to the T(H)1-T(H)2 paradigm in swine?
    Michael P Murtaugh
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Dev Comp Immunol 33:344-52. 2009
  5. ncbi Nucleotide and deduced amino acid sequence of porcine interleukin 4 cDNA derived from lamina propria lymphocytes
    M Bailey
    Department of Veterinary Medicine, University of Bristol, UK
    Biochim Biophys Acta 1171:328-30. 1993
  6. ncbi Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig
    G Rettenberger
    Department of Medical Genetics, University of Ulm, D 89069 Ulm, Germany
    Mamm Genome 7:275-9. 1996
  7. ncbi Porcine endothelial cells and iliac arteries transduced with AdenoIL-4 are intrinsically protected, through Akt activation, against immediate injury caused by human complement
    Sylvester M Black
    Department of Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 177:7355-63. 2006
  8. doi Effect of cryopreservation on IL-4, IFNgamma and IL-6 production of porcine peripheral blood lymphocytes
    Xiujin Li
    Dept of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China
    Cryobiology 59:322-6. 2009
  9. doi IL-4 induces protection of vascular endothelial cells against killing by complement and melittin through lipid biosynthesis
    Sylvester M Black
    Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Immunol 40:803-12. 2010
  10. doi Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response
    Sae Jin Oh
    Department of Pathology, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Immunol 186:6815-21. 2011

Scientific Experts

  • Michael P Murtaugh
  • Agustin P Dalmasso
  • Barbara A Benson
  • Sylvester M Black
  • Brett K Levay-Young
  • John F Grehan
  • Sae Jin Oh
  • Xiujin Li
  • Gregory M Vercellotti
  • Alexander K Tsai
  • Karen R Wasiluk
  • Daniel Goldish
  • Doo Hyun Chung
  • Megan E Schott
  • Bjorn H Batdorf
  • Mark S Rutherford
  • Xingxing Wang
  • Fei Zhong
  • Zhenyu Zhong
  • Shuang Liang
  • Andrea E Wahner
  • Andrew L Rivard
  • Alisa E Koch
  • Vanessa François-Bongarçon
  • Jeremy L Fogelson
  • G Rettenberger
  • Y Zhou
  • M Bailey
  • A L Archibald
  • H Hameister
  • R Fries
  • J Bruch
  • R W Scamurra
  • G Lin
  • M J Baarsch
  • P W Bland
  • C R Stokes
  • L Hall
  • A C Perry

Detail Information

Publications10

  1. ncbi Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages
    Y Zhou
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul
    J Leukoc Biol 56:507-13. 1994
    ....
  2. ncbi IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway
    John F Grehan
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 175:1903-10. 2005
    ..We conclude that IL-4 and IL-13 can induce protection of porcine EC against killing by apoptosis and human complement through activation of the PI3K/Akt signaling pathway...
  3. pmc Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury
    Agustin P Dalmasso
    From the Departments of Surgery
    J Biol Chem 289:838-47. 2014
    ....
  4. doi Species specialization in cytokine biology: is interleukin-4 central to the T(H)1-T(H)2 paradigm in swine?
    Michael P Murtaugh
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Dev Comp Immunol 33:344-52. 2009
    ....
  5. ncbi Nucleotide and deduced amino acid sequence of porcine interleukin 4 cDNA derived from lamina propria lymphocytes
    M Bailey
    Department of Veterinary Medicine, University of Bristol, UK
    Biochim Biophys Acta 1171:328-30. 1993
    ..b>Interleukin 4 transcripts were then specifically amplified by PCR...
  6. ncbi Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig
    G Rettenberger
    Department of Medical Genetics, University of Ulm, D 89069 Ulm, Germany
    Mamm Genome 7:275-9. 1996
    Nineteen so-called type I-loci, including ACO2, ADRA2, CAST, CCK, CHAT, IGKC, IGLV, IL4, IL6, INHA, LIF, MX1, PTH, RBP2, TCRA, TCRB, TGFB2, TGFB3, and UOX have been mapped in the pig with an informative somatic cell hybrid panel...
  7. ncbi Porcine endothelial cells and iliac arteries transduced with AdenoIL-4 are intrinsically protected, through Akt activation, against immediate injury caused by human complement
    Sylvester M Black
    Department of Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 177:7355-63. 2006
    ....
  8. doi Effect of cryopreservation on IL-4, IFNgamma and IL-6 production of porcine peripheral blood lymphocytes
    Xiujin Li
    Dept of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China
    Cryobiology 59:322-6. 2009
    ..There was no significant difference of IL-4 production between fresh and frozen cells either stimulated (P>0.05) or un-stimulated (P>0.05)...
  9. doi IL-4 induces protection of vascular endothelial cells against killing by complement and melittin through lipid biosynthesis
    Sylvester M Black
    Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Immunol 40:803-12. 2010
    ..We conclude that IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against MAC and melittin, in association with mitochondrial protection...
  10. doi Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response
    Sae Jin Oh
    Department of Pathology, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Immunol 186:6815-21. 2011
    ..Moreover, IFN-γ-producing iNKT cells have a minimal role in the regulation of the Th1 and Th17 responses in EAE...