Gene Symbol: IKBKG
Description: inhibitor of nuclear factor kappa B kinase subunit gamma
Alias: NF-kappa-B essential modulator, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Species: pig

Top Publications

  1. Wang D, Fang L, Li K, Zhong H, Fan J, Ouyang C, et al. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling. J Virol. 2012;86:9311-22 pubmed publisher
    ..Collectively, our data identify NEMO as a substrate for FMDV 3C(pro) and reveal a novel mechanism evolved by a picornavirus to counteract innate immune signaling...
  2. Huang C, Zhang Q, Guo X, Yu Z, Xu A, Tang J, et al. Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-?B essential modulator. J Virol. 2014;88:10934-45 pubmed publisher
    ..The data presented here may help us to better understand PRRSV pathogenesis. ..
  3. Zhu X, Fang L, Wang D, Yang Y, Chen J, Ye X, et al. Porcine deltacoronavirus nsp5 inhibits interferon-? production through the cleavage of NEMO. Virology. 2017;502:33-38 pubmed publisher
    ..Taken together, our findings reveal PDCoV nsp5 to be a newly identified IFN antagonist and enhance the understanding of immune evasion by deltacoronaviruses. ..