IGF2

Summary

Gene Symbol: IGF2
Description: insulin-like growth factor 2 (somatomedin A)
Alias: IGF-II, insulin-like growth factor II, preptin
Species: pig

Top Publications

  1. ncbi Nucleotide sequence of a porcine insulin-like growth factor II cDNA
    I R Catchpole
    Karolinska Institute, Centre for Biotechnology, Huddinge, Sweden
    Nucleic Acids Res 18:6430. 1990
  2. ncbi Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds
    M Oczkowicz
    National Research Institute of Animal Production, Department of Animal Genetics and Breeding, Poland
    J Appl Genet 50:257-9. 2009
  3. ncbi Genetic imprinting of H19 and IGF2 in domestic pigs (Sus scrofa)
    Chao Li
    College of Animal Science, South China Agricultural University, Guangzhou, People s Republic of China
    Anim Biotechnol 19:22-7. 2008
  4. ncbi [Genetic polymorphisms and genetic effects of IGF2 gene in pigs]
    Hui Liang Xue
    College of Life Science, Qufu Normal University, Qufu, Shandong 273165, China
    Yi Chuan 30:179-84. 2008
  5. ncbi Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2
    A Ojeda
    Institut Català de Recerca i Estudis Avançats, 08010 Barcelona, Spain
    Genetics 178:1639-52. 2008
  6. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
  7. ncbi The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross
    Bart J Jungerius
    Department of Animal Breeding and Genetics, Wageningen University, P O Box 40, 6700 AH Wageningen, The Netherlands
    Genet Res 84:95-101. 2004
  8. ncbi Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs
    Valerie Amarger
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    Mamm Genome 13:388-98. 2002
  9. ncbi IGF expression patterns and regulation in growth plate chondrocytes
    Werner Schlegel
    Medical University of Vienna, Department of Paediatrics and Adolescent Medicine, Vienna, Austria
    Mol Cell Endocrinol 327:65-71. 2010
  10. ncbi Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
    Maria Munoz
    Departamento de Mejora Genética Animal, INIA, Ctra de La Coruña Km 7 5, Madrid, Spain
    Genet Sel Evol 42:23. 2010

Scientific Experts

  • B J Jungerius
  • Z Vykoukalová
  • Huai Pu Chang
  • Yu Jiao Guo
  • Maria Munoz
  • Martin H Braunschweig
  • Carine Nezer
  • Lijuan Wang
  • Werner Schlegel
  • Nadine Buys
  • Chi Hun Park
  • M Oczkowicz
  • Steve R Bischoff
  • Michel Georges
  • Anne Sophie Van Laere
  • Leif Andersson
  • A Stinckens
  • A Ojeda
  • Chao Li
  • Delphine Gardan
  • Hui Liang Xue
  • Karijn Van den Maagdenberg
  • Catherine Collette
  • Laurence Moreau
  • Anne-Sophie Van Laere
  • Minh Nguyen
  • Valerie Amarger
  • Baochun Jiang
  • Honglin Liu
  • Fulu Dong
  • Guangmin Zhang
  • Fei Lin
  • Daniel Halbauer
  • Daniela Scharmer
  • Adalbert Raimann
  • Magda Helmreich
  • Christian Albrecht
  • Monika Egerbacher
  • Susanne Sagmeister
  • Gabriele Häusler
  • M Georges
  • Nicholas Hardison
  • M Tyra
  • Dan Nonneman
  • T Luyten
  • S De Smet
  • S Janssens
  • Shengdar Tsai
  • Jorge A Piedrahita
  • Gary Rohrer
  • Hye Sun Kim
  • Sang Goo Lee
  • Alison A Motsinger-Reif
  • K Walinowicz
  • N Buys
  • K Van den Maagdenberg
  • Brad A Freking
  • M Rozycki
  • B Rejduch
  • Chang Kyu Lee
  • Jacques Mourot
  • Lan Yang
  • Lai Xiang Xu
  • Michael O'Neill
  • J Ren
  • L-S Huang
  • S M Makuza
  • I C Cho
  • A Angiolillo
  • I-C Cho
  • Qingyan Jiang
  • C Lemus-Flores
  • L S Huang
  • X Cindy Tian
  • Isabelle Louveau
  • M Perez-Enciso
  • Dingyuan Feng
  • H Soto
  • J M Folch
  • Yanfang Bin
  • Shouquan Zhang
  • Carol Curchoe
  • Stefaan De Smet
  • Anneleen Stinckens
  • Erik Claeys
  • Goran Andersson
  • Jong-Joo Kim
  • Jong Joo Kim
  • Alan L Archibald
  • Chris S Haley

Detail Information

Publications22

  1. ncbi Nucleotide sequence of a porcine insulin-like growth factor II cDNA
    I R Catchpole
    Karolinska Institute, Centre for Biotechnology, Huddinge, Sweden
    Nucleic Acids Res 18:6430. 1990
  2. ncbi Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds
    M Oczkowicz
    National Research Institute of Animal Production, Department of Animal Genetics and Breeding, Poland
    J Appl Genet 50:257-9. 2009
    b>IGF2 is one of the genes that control muscle development. Moreover, IGF2 is imprinted, as only the paternal allele is expressed in the offspring. Using real-time PCR for IGF2 genotyping (Carrodegous et al...
  3. ncbi Genetic imprinting of H19 and IGF2 in domestic pigs (Sus scrofa)
    Chao Li
    College of Animal Science, South China Agricultural University, Guangzhou, People s Republic of China
    Anim Biotechnol 19:22-7. 2008
    The genes insulin-like growth factor 2 (IGF2) and H19 express paternally and maternally, respectively, in humans, mice, sheep, and cattle...
  4. ncbi [Genetic polymorphisms and genetic effects of IGF2 gene in pigs]
    Hui Liang Xue
    College of Life Science, Qufu Normal University, Qufu, Shandong 273165, China
    Yi Chuan 30:179-84. 2008
    Single nucleotide polymorphisms of the exon7, 8, 9 of the porcine IGF2 gene were tested using PCR-SSCP. Genetic effects of the IGF2 gene on birth weight, weaning weight, six-month weight and six-month backfat thickness were analyzed...
  5. ncbi Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2
    A Ojeda
    Institut Català de Recerca i Estudis Avançats, 08010 Barcelona, Spain
    Genetics 178:1639-52. 2008
    ..We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars...
  6. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..A paternally expressed QTL affecting muscle growth, fat deposition and size of the heart in pigs maps to the IGF2 (insulin-like growth factor 2) region...
  7. ncbi The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross
    Bart J Jungerius
    Department of Animal Breeding and Genetics, Wageningen University, P O Box 40, 6700 AH Wageningen, The Netherlands
    Genet Res 84:95-101. 2004
    A paternally expressed QTL for muscle growth and backfat thickness (BFT) has previously been identified near the IGF2 locus on the distal tip of pig chromosome 2 (SSC2p) in three experimental F2 populations...
  8. ncbi Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs
    Valerie Amarger
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    Mamm Genome 13:388-98. 2002
    b>IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development...
  9. ncbi IGF expression patterns and regulation in growth plate chondrocytes
    Werner Schlegel
    Medical University of Vienna, Department of Paediatrics and Adolescent Medicine, Vienna, Austria
    Mol Cell Endocrinol 327:65-71. 2010
    ..The abundant expression of IGF-II in porcine growth plate tissue, both on the mRNA and on the protein level, suggests that IGF-II also has a role in growth regulation at the early postnatal stage...
  10. ncbi Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
    Maria Munoz
    Departamento de Mejora Genética Animal, INIA, Ctra de La Coruña Km 7 5, Madrid, Spain
    Genet Sel Evol 42:23. 2010
    The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes...
  11. ncbi Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor
    A Stinckens
    Departement of Biosystems, KULeuven, 3001 Heverlee, Belgium
    Domest Anim Endocrinol 37:227-35. 2009
    ..In both skeletal muscle and heart muscle growth, the IGF-2:MSTN ratio seems to play an important role. Also, the RYR1 genotype had a significant effect on IGF-2 expression in m. longissimus dorsi. No effect of the MC4R QTN could be seen...
  12. ncbi Expression of the insulin-like growth factor system in skeletal muscle during embryonic and postnatal development in the first filial generation pigs from Erhualian and Yorkshire reciprocal crosses
    Lijuan Wang
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Gen Comp Endocrinol 173:56-62. 2011
    ..Our results may provide a valuable resource for the molecular breeding of pigs...
  13. ncbi Characterization of conserved and nonconserved imprinted genes in swine
    Steve R Bischoff
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina 27606, USA
    Biol Reprod 81:906-20. 2009
    ..as differentially expressed in at least one of the four tissue types: AMPD3, CDKN1C, COPG2, DHCR7, DIRAS3, IGF2 (isoform specific), IGF2AS, IGF2R, MEG3, MEST, NAP1L5, NDN, NNAT, OSBPL1A, PEG3, APEG3, PEG10, PLAGL1, PON2, ..
  14. ncbi Methylation status of differentially methylated regions at Igf2/H19 locus in porcine gametes and preimplantation embryos
    Chi Hun Park
    Department of Agricultural Biotechnology, Seoul National University San 56 1 Shillim dong Gwanak gu, Seoul 151 921, Korea
    Genomics 93:179-86. 2009
    ..For the methylation analysis, the primers for the three Igf2/H19 DMRs were designed and based upon previously published sequences...
  15. ncbi Decreased expression of the IGF-II gene during porcine adipose cell differentiation
    Delphine Gardan
    INRA, UMR 1079, F 35000 Rennes, France
    Mol Cell Endocrinol 292:63-8. 2008
    ..Cell differentiation was also associated with an increase in the expression of IGF-I, insulin and IGF receptor genes. The current findings suggest that IGF-I and IGF-II have different effects on porcine adipose cell development...
  16. ncbi [Developmental expression changes of IGF2 and IGFBP3 genes in adipose tissue of two pig breeds]
    Yu Jiao Guo
    College of Animal Science and Technology, Sichuan Agricultural University, Ya an 625014, China
    Yi Chuan 30:602-6. 2008
    To investigate the developmental expression patterns of Insulin-like Growth Factor 2 (IGF2) and Insulin-like Growth Factor Binding protein 3 (IGFBP3) genes at the age of 30, 60, 90, 120 and 150 days in back subcutaneous fat tissue of ..
  17. ncbi [Single nucleotide polymorphism analysis on the 5' regulatory region of IGF2 gene in Wuzhishan pig]
    Huai Pu Chang
    College of Life Science and Technology, Southwest University for Nationalities, Chengdu, China
    Yi Chuan 29:57-64. 2007
    Single nucleotide polymorphisms (SNPs) in partial 5' regulatory region of the insulin-like growth factor 2 (IGF2) gene were studied by DNA sequencing in 60 pigs from the Wuzhishan, Diannan small-ear, Xiang, Meishan and Large White pig ..
  18. ncbi New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs
    Z Vykoukalová
    Department of Morphology, Physiology and Genetics of Animals, Mendel University of Agriculture and Forestry Brno, Brno, Czech Republic
    J Anim Breed Genet 123:204-7. 2006
    b>IGF2-in3-G3072A is a causative mutation for paternally expressed quantitative trait loci on the p arm of porcine chromosome 2 with substantial effect on muscle growth and backfat thickness...
  19. ncbi Differences in proteolytic enzyme activities during growth of the pig with different IGF-II genotypes
    Karijn Van den Maagdenberg
    Department of Animal Production, Ghent University, Proefhoevestraat 10, B-9090 Melle, Belgium
    Commun Agric Appl Biol Sci 69:297-300. 2004
  20. ncbi Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene
    Carine Nezer
    Department of Genetics, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
    Genetics 165:277-85. 2003
    ..by all "Q" chromosomes, we map the QTL to an approximately 250-kb chromosome segment containing INS and IGF2 as the only known paternally expressed genes...
  21. ncbi Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II
    G L Francis
    CSIRO Division of Human Nutrition, Adelaide, South Australia
    J Endocrinol 122:681-7. 1989
    ..05%. Porcine IGF-I exhibited a higher cross-reactivity, presumably due to very slight contamination with IGF-II...
  22. ncbi Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2
    Martin H Braunschweig
    Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Berne, Switzerland
    BMC Genet 12:47. 2011
    Porcine IGF2 and the H19 genes are imprinted. The IGF2 is paternally expressed, while the H19 gene is maternally expressed...