IGF2

Summary

Gene Symbol: IGF2
Description: insulin like growth factor 2
Alias: IGF-II, insulin-like growth factor II, insulin-like growth factor 2 (somatomedin A), preptin
Species: pig

Top Publications

  1. Catchpole I, Engstrom W. Nucleotide sequence of a porcine insulin-like growth factor II cDNA. Nucleic Acids Res. 1990;18:6430 pubmed
  2. Oczkowicz M, Tyra M, Walinowicz K, Rozycki M, Rejduch B. Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds. J Appl Genet. 2009;50:257-9 pubmed publisher
    b>IGF2 is one of the genes that control muscle development. Moreover, IGF2 is imprinted, as only the paternal allele is expressed in the offspring. Using real-time PCR for IGF2 genotyping (Carrodegous et al...
  3. Li C, Bin Y, Curchoe C, Yang L, Feng D, Jiang Q, et al. Genetic imprinting of H19 and IGF2 in domestic pigs (Sus scrofa). Anim Biotechnol. 2008;19:22-7 pubmed publisher
    The genes insulin-like growth factor 2 (IGF2) and H19 express paternally and maternally, respectively, in humans, mice, sheep, and cattle...
  4. Xue H, Xu L. [Genetic polymorphisms and genetic effects of IGF2 gene in pigs]. Yi Chuan. 2008;30:179-84 pubmed
    Single nucleotide polymorphisms of the exon7, 8, 9 of the porcine IGF2 gene were tested using PCR-SSCP. Genetic effects of the IGF2 gene on birth weight, weaning weight, six-month weight and six-month backfat thickness were analyzed...
  5. Ojeda A, Huang L, Ren J, Angiolillo A, Cho I, Soto H, et al. Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2. Genetics. 2008;178:1639-52 pubmed publisher
    ..We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars...
  6. Van Laere A, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature. 2003;425:832-6 pubmed
    ..A paternally expressed QTL affecting muscle growth, fat deposition and size of the heart in pigs maps to the IGF2 (insulin-like growth factor 2) region...
  7. Jungerius B, Van Laere A, te Pas M, van Oost B, Andersson L, Groenen M. The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross. Genet Res. 2004;84:95-101 pubmed
    A paternally expressed QTL for muscle growth and backfat thickness (BFT) has previously been identified near the IGF2 locus on the distal tip of pig chromosome 2 (SSC2p) in three experimental F2 populations...
  8. Amarger V, Nguyen M, Van Laere A, Braunschweig M, Nezer C, Georges M, et al. Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs. Mamm Genome. 2002;13:388-98 pubmed
    b>IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development...
  9. Braunschweig M, Owczarek Lipska M, Stahlberger Saitbekova N. Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2. BMC Genet. 2011;12:47 pubmed publisher
    Porcine IGF2 and the H19 genes are imprinted. The IGF2 is paternally expressed, while the H19 gene is maternally expressed...
  10. Lahbib Mansais Y, Barasc H, Marti Marimon M, Mompart F, Iannuccelli E, Robelin D, et al. Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells. BMC Cell Biol. 2016;17:35 pubmed
    ..compared the nuclear organization of the two parental alleles (expressed or not) of insulin-like growth factor 2 (IGF2), a paternally imprinted gene located on chromosome 2...

Detail Information

Publications29

  1. Catchpole I, Engstrom W. Nucleotide sequence of a porcine insulin-like growth factor II cDNA. Nucleic Acids Res. 1990;18:6430 pubmed
  2. Oczkowicz M, Tyra M, Walinowicz K, Rozycki M, Rejduch B. Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds. J Appl Genet. 2009;50:257-9 pubmed publisher
    b>IGF2 is one of the genes that control muscle development. Moreover, IGF2 is imprinted, as only the paternal allele is expressed in the offspring. Using real-time PCR for IGF2 genotyping (Carrodegous et al...
  3. Li C, Bin Y, Curchoe C, Yang L, Feng D, Jiang Q, et al. Genetic imprinting of H19 and IGF2 in domestic pigs (Sus scrofa). Anim Biotechnol. 2008;19:22-7 pubmed publisher
    The genes insulin-like growth factor 2 (IGF2) and H19 express paternally and maternally, respectively, in humans, mice, sheep, and cattle...
  4. Xue H, Xu L. [Genetic polymorphisms and genetic effects of IGF2 gene in pigs]. Yi Chuan. 2008;30:179-84 pubmed
    Single nucleotide polymorphisms of the exon7, 8, 9 of the porcine IGF2 gene were tested using PCR-SSCP. Genetic effects of the IGF2 gene on birth weight, weaning weight, six-month weight and six-month backfat thickness were analyzed...
  5. Ojeda A, Huang L, Ren J, Angiolillo A, Cho I, Soto H, et al. Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2. Genetics. 2008;178:1639-52 pubmed publisher
    ..We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars...
  6. Van Laere A, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature. 2003;425:832-6 pubmed
    ..A paternally expressed QTL affecting muscle growth, fat deposition and size of the heart in pigs maps to the IGF2 (insulin-like growth factor 2) region...
  7. Jungerius B, Van Laere A, te Pas M, van Oost B, Andersson L, Groenen M. The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross. Genet Res. 2004;84:95-101 pubmed
    A paternally expressed QTL for muscle growth and backfat thickness (BFT) has previously been identified near the IGF2 locus on the distal tip of pig chromosome 2 (SSC2p) in three experimental F2 populations...
  8. Amarger V, Nguyen M, Van Laere A, Braunschweig M, Nezer C, Georges M, et al. Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs. Mamm Genome. 2002;13:388-98 pubmed
    b>IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development...
  9. Braunschweig M, Owczarek Lipska M, Stahlberger Saitbekova N. Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2. BMC Genet. 2011;12:47 pubmed publisher
    Porcine IGF2 and the H19 genes are imprinted. The IGF2 is paternally expressed, while the H19 gene is maternally expressed...
  10. Lahbib Mansais Y, Barasc H, Marti Marimon M, Mompart F, Iannuccelli E, Robelin D, et al. Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells. BMC Cell Biol. 2016;17:35 pubmed
    ..compared the nuclear organization of the two parental alleles (expressed or not) of insulin-like growth factor 2 (IGF2), a paternally imprinted gene located on chromosome 2...
  11. Aslan O, Hamill R, Davey G, McBryan J, Mullen A, Gispert M, et al. Variation in the IGF2 gene promoter region is associated with intramuscular fat content in porcine skeletal muscle. Mol Biol Rep. 2012;39:4101-10 pubmed publisher
    ..A QTN located in the insulin-like growth factor 2 gene (IGF2) has been associated with a desirable reduction in BF depth in pigs...
  12. Burgos C, Galve A, Moreno C, Altarriba J, Reina R, Garc a C, et al. The effects of two alleles of IGF2 on fat content in pig carcasses and pork. Meat Sci. 2012;90:309-13 pubmed publisher
    The different fat infiltration capabilities of two alleles of IGF2 (G3072A) have been investigated in pigs of a Landrace-Large White×Duroc cross...
  13. Uh K, Park C, Choi K, Park J, Jeong Y, Roh S, et al. Analysis of imprinted IGF2/H19 gene methylation and expression in normal fertilized and parthenogenetic embryonic stem cells of pigs. Anim Reprod Sci. 2014;147:47-55 pubmed publisher
    ..during the process of embryonic stem (ES) cell derivation from pig blastocysts, mRNA and DNA methylation at the IGF2/H19 imprinting control region in putative ES cells derived from in vitro fertilized (IVF) and parthenogenetic (PG) ..
  14. Clark D, Bohrer B, Tavárez M, Boler D, Beever J, Dilger A. Effects of the porcine IGF2 intron 3-G3072A mutation on carcass cutability, meat quality, and bacon processing. J Anim Sci. 2014;92:5778-88 pubmed publisher
    A SNP in a regulatory region of intron 3 within the porcine IGF2 gene (IGF2-G3072A) is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles (APat) compared with pigs with paternal G ..
  15. Nezer C, Collette C, Moreau L, Brouwers B, Kim J, Giuffra E, et al. Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene. Genetics. 2003;165:277-85 pubmed
    ..by all "Q" chromosomes, we map the QTL to an approximately 250-kb chromosome segment containing INS and IGF2 as the only known paternally expressed genes...
  16. Wang L, Zhang G, Lin F, Jiang B, Dong F, Liu H. Expression of the insulin-like growth factor system in skeletal muscle during embryonic and postnatal development in the first filial generation pigs from Erhualian and Yorkshire reciprocal crosses. Gen Comp Endocrinol. 2011;173:56-62 pubmed publisher
    ..Our results may provide a valuable resource for the molecular breeding of pigs. ..
  17. Stinckens A, Luyten T, Van den Maagdenberg K, Janssens S, De Smet S, Georges M, et al. Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor. Domest Anim Endocrinol. 2009;37:227-35 pubmed publisher
    ..Also, the RYR1 genotype had a significant effect on IGF-2 expression in m. longissimus dorsi. No effect of the MC4R QTN could be seen. ..
  18. Francis G, Owens P, McNeil K, Wallace J, Ballard F. Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II. J Endocrinol. 1989;122:681-7 pubmed
    ..05%. Porcine IGF-I exhibited a higher cross-reactivity, presumably due to very slight contamination with IGF-II. ..
  19. Chang H, Ou J, Zhong J, Wang X, Guo C, Bin S, et al. [Single nucleotide polymorphism analysis on the 5' regulatory region of IGF2 gene in Wuzhishan pig]. Yi Chuan. 2007;29:57-64 pubmed
    Single nucleotide polymorphisms (SNPs) in partial 5' regulatory region of the insulin-like growth factor 2 (IGF2) gene were studied by DNA sequencing in 60 pigs from the Wuzhishan, Diannan small-ear, Xiang, Meishan and Large White pig ..
  20. Vykoukalová Z, Knoll A, Dvorak J, Cepica S. New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs. J Anim Breed Genet. 2006;123:204-7 pubmed
    b>IGF2-in3-G3072A is a causative mutation for paternally expressed quantitative trait loci on the p arm of porcine chromosome 2 with substantial effect on muscle growth and backfat thickness...
  21. Bischoff S, Tsai S, Hardison N, Motsinger Reif A, Freking B, Nonneman D, et al. Characterization of conserved and nonconserved imprinted genes in swine. Biol Reprod. 2009;81:906-20 pubmed publisher
    ..as differentially expressed in at least one of the four tissue types: AMPD3, CDKN1C, COPG2, DHCR7, DIRAS3, IGF2 (isoform specific), IGF2AS, IGF2R, MEG3, MEST, NAP1L5, NDN, NNAT, OSBPL1A, PEG3, APEG3, PEG10, PLAGL1, PON2, ..
  22. Mu oz M, Fern ndez A, Ovilo C, Mu oz G, Rodriguez C, Fern ndez A, et al. Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line. Genet Sel Evol. 2010;42:23 pubmed publisher
    The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes...
  23. Park C, Kim H, Lee S, Lee C. Methylation status of differentially methylated regions at Igf2/H19 locus in porcine gametes and preimplantation embryos. Genomics. 2009;93:179-86 pubmed publisher
    ..For the methylation analysis, the primers for the three Igf2/H19 DMRs were designed and based upon previously published sequences...
  24. Guo Y, Tang G, Li X, Zhu L, Li M. [Developmental expression changes of IGF2 and IGFBP3 genes in adipose tissue of two pig breeds]. Yi Chuan. 2008;30:602-6 pubmed
    To investigate the developmental expression patterns of Insulin-like Growth Factor 2 (IGF2) and Insulin-like Growth Factor Binding protein 3 (IGFBP3) genes at the age of 30, 60, 90, 120 and 150 days in back subcutaneous fat tissue of ..
  25. Van den Maagdenberg K, Claeys E, Stinckens A, Buys N, De Smet S. Differences in proteolytic enzyme activities during growth of the pig with different IGF-II genotypes. Commun Agric Appl Biol Sci. 2004;69:297-300 pubmed
  26. Schlegel W, Halbauer D, Raimann A, Albrecht C, Scharmer D, Sagmeister S, et al. IGF expression patterns and regulation in growth plate chondrocytes. Mol Cell Endocrinol. 2010;327:65-71 pubmed publisher
    ..The abundant expression of IGF-II in porcine growth plate tissue, both on the mRNA and on the protein level, suggests that IGF-II also has a role in growth regulation at the early postnatal stage. ..
  27. Gardan D, Mourot J, Louveau I. Decreased expression of the IGF-II gene during porcine adipose cell differentiation. Mol Cell Endocrinol. 2008;292:63-8 pubmed publisher
    ..Cell differentiation was also associated with an increase in the expression of IGF-I, insulin and IGF receptor genes. The current findings suggest that IGF-I and IGF-II have different effects on porcine adipose cell development. ..
  28. Miese Looy G, van den Heuvel M, Edwards A, LaMarre J, Tayade C. Expression of insulin-like growth factor (IGF) family members in porcine pregnancy. J Reprod Dev. 2012;58:51-60 pubmed
    ..Our results suggest that IGF-I and II and their receptors are differentially expressed at the maternal and fetal components of the attachment site. ..
  29. Oczkowicz M, Mucha A, Tyra M, Ropka Molik K, Piórkowska K. Lack of the associations of the polymorphisms in IGF2, MC4R and GNAS genes with reproduction traits in pigs and imprinting analysis of IGF2 gene in ovary and cornus uteri. Reprod Domest Anim. 2013;48:562-8 pubmed publisher
    ..In our study, we investigated associations between polymorphisms in IGF2, GNAS and MC4R genes with reproductive traits of Polish Landrace and Large White pigs...