Genomes and Genes
Gene Symbol: IFNB1
Description: interferon beta 1
Alias: IFN-beta, IFNb, interferon beta, interferon-beta
- Chen Z, Liu S, Sun W, Chen L, Yoo D, Li F, et al. Nuclear export signal of PRRSV NSP1? is necessary for type I IFN inhibition. Virology. 2016;499:278-287 pubmed publisher..Taken together, our results describe a novel mechanism of PRRSV NSP1? for type I IFN inhibition and suppression of the host innate antiviral response. ..
- Overend C, Cui J, Grubman M, Garmendia A. The activation of the IFN? induction/signaling pathway in porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus is variable. Vet Res Commun. 2017;41:15-22 pubmed publisher..effects of PRRSV infection of porcine alveolar macrophages (PAMs), the main target cell, on the expression of interferon beta (IFN?) and downstream signaling events...
- Zhang H, Guo X, Nelson E, Christopher Hennings J, Wang X. Porcine reproductive and respiratory syndrome virus activates the transcription of interferon alpha/beta (IFN-?/?) in monocyte-derived dendritic cells (Mo-DC). Vet Microbiol. 2012;159:494-8 pubmed publisher..We conclude that PRRSV inhibits the induction of IFN-? in Mo-DC by as yet undefined post-transcriptional mechanisms...
- Wen G, Zhang Y, Zhang X, Hu H, Zhang H, Cheng C, et al. Functional characterization of porcine LSm14A in IFN-? induction. Vet Immunol Immunopathol. 2013;155:110-6 pubmed publisher..Since pLSm14A is constitutively expressed in virtually all tissues, more research is needed to explore its role in initial phase of viral infections of pigs and its relationship with RIG-I in sensing PAMPs for type I IFN induction. ..
- Zhu X, Fang L, Wang D, Yang Y, Chen J, Ye X, et al. Porcine deltacoronavirus nsp5 inhibits interferon-? production through the cleavage of NEMO. Virology. 2017;502:33-38 pubmed publisher..Taken together, our findings reveal PDCoV nsp5 to be a newly identified IFN antagonist and enhance the understanding of immune evasion by deltacoronaviruses. ..