IFNB1

Summary

Gene Symbol: IFNB1
Description: interferon beta 1
Alias: IFN-beta, IFNb, interferon beta, interferon-beta
Species: pig
Products:     IFNB1

Top Publications

  1. Artursson K, Gobl A, Lindersson M, Johansson M, Alm G. Molecular cloning of a gene encoding porcine interferon-beta. J Interferon Res. 1992;12:153-60 pubmed
    ..The latter approach in addition detected only about one IFN-beta mRNA-containing cell per 2,000 PRV-stimulated porcine leukocytes, a frequency in the same range as that for leukocytes containing IFN-alpha mRNA. ..
  2. Cao R, Zhou G, Zhou H, Bao J, Chen P. [Secreted expression of porcine interferon beta in Pichia pastoris and its inhibition effect on the replication of Pseudorabies virus]. Wei Sheng Wu Xue Bao. 2006;46:412-7 pubmed
    In order to develop recombinant porcine interferon beta with high bioactivity, the rare codes that encoded 3th, 7th and 164th amino acids of porcine interferon beta mature protein were mutant into bias codes of Pichia pastoris and then ..
  3. Zhu X, Wang D, Zhang H, Zhou Y, Luo R, Chen H, et al. Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41). Dev Comp Immunol. 2014;47:191-6 pubmed publisher
    ..Therefore, poDDX41 is involved in the dsDNA- and dsDNA-virus-mediated type I IFN signaling pathway in porcine kidney cells. ..
  4. Zhang Q, Shi K, Yoo D. Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1. Virology. 2016;489:252-68 pubmed publisher
    ..A further study showed that the CBP degradation by nsp1 was proteasome-dependent. Our data demonstrate that PEDV modulates the host innate immune responses by degrading CBP and suppressing ISGs expression. ..
  5. Chinsangaram J, Koster M, Grubman M. Inhibition of L-deleted foot-and-mouth disease virus replication by alpha/beta interferon involves double-stranded RNA-dependent protein kinase. J Virol. 2001;75:5498-503 pubmed
    ..In addition, results of FMDV infection in mouse embryonic fibroblast cells derived from gene knockout mice lacking the gene for RNase L(-/-) or PKR(-/-) or both indicated an important role for PKR in the inhibition of FMDV replication. ..
  6. Lee J, Zhang W, Moran C. Comparative porcine gene mapping relative to human chromosomes 9, 10, 20 and 22. Anim Genet. 2001;32:313-5 pubmed
  7. He D, Niu X, Jiang A, Su D, Zhong W, Hu J, et al. swIFN-? promotes genetic mutation of porcine reproductive and respiratory syndrome virus in Marc-145. Vet Microbiol. 2013;166:174-8 pubmed publisher
    ..The immuno-pressure of swIFN-? accelerated genetic variation on PRRSV ORF5, NSP2 and ORF3, but not on the ORF6 gene. PRRSV NSP2 and ORF5 genes may play a key role in escaping from inhibition of swIFN-?. ..
  8. Huang C, Zhang Q, Guo X, Yu Z, Xu A, Tang J, et al. Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-?B essential modulator. J Virol. 2014;88:10934-45 pubmed publisher
    ..The data presented here may help us to better understand PRRSV pathogenesis. ..
  9. Li Y, Wen Z, Zhou H, Wu S, Jia G, Qian W, et al. Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-β production. Dev Comp Immunol. 2015;50:49-57 pubmed publisher
    ..This study suggests that poIFIT3 plays a significant role in the clearance of SIV in pigs and potentiates IFN-β production. ..

More Information

Publications15

  1. Chen Z, Liu S, Sun W, Chen L, Yoo D, Li F, et al. Nuclear export signal of PRRSV NSP1? is necessary for type I IFN inhibition. Virology. 2016;499:278-287 pubmed publisher
    ..Taken together, our results describe a novel mechanism of PRRSV NSP1? for type I IFN inhibition and suppression of the host innate antiviral response. ..
  2. Overend C, Cui J, Grubman M, Garmendia A. The activation of the IFN? induction/signaling pathway in porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus is variable. Vet Res Commun. 2017;41:15-22 pubmed publisher
    ..effects of PRRSV infection of porcine alveolar macrophages (PAMs), the main target cell, on the expression of interferon beta (IFN?) and downstream signaling events...
  3. Zhang H, Guo X, Nelson E, Christopher Hennings J, Wang X. Porcine reproductive and respiratory syndrome virus activates the transcription of interferon alpha/beta (IFN-?/?) in monocyte-derived dendritic cells (Mo-DC). Vet Microbiol. 2012;159:494-8 pubmed publisher
    ..We conclude that PRRSV inhibits the induction of IFN-? in Mo-DC by as yet undefined post-transcriptional mechanisms...
  4. Wen G, Zhang Y, Zhang X, Hu H, Zhang H, Cheng C, et al. Functional characterization of porcine LSm14A in IFN-? induction. Vet Immunol Immunopathol. 2013;155:110-6 pubmed publisher
    ..Since pLSm14A is constitutively expressed in virtually all tissues, more research is needed to explore its role in initial phase of viral infections of pigs and its relationship with RIG-I in sensing PAMPs for type I IFN induction. ..
  5. Ren Y, Khan F, Pandupuspitasari N, Li S, Hao X, Chen X, et al. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Modulates Interferon-? Expression Mainly Through Attenuating Interferon-Regulatory Factor 3 Phosphorylation. DNA Cell Biol. 2016;35:489-97 pubmed publisher
  6. Zhu X, Fang L, Wang D, Yang Y, Chen J, Ye X, et al. Porcine deltacoronavirus nsp5 inhibits interferon-? production through the cleavage of NEMO. Virology. 2017;502:33-38 pubmed publisher
    ..Taken together, our findings reveal PDCoV nsp5 to be a newly identified IFN antagonist and enhance the understanding of immune evasion by deltacoronaviruses. ..