Gene Symbol: IFITM3
Description: interferon induced transmembrane protein 3
Alias: IFITM2, interferon-induced transmembrane protein 3, interferon-induced transmembrane protein 2
Miller L, Jiang Z, Sang Y, Harhay G, Lager K. Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses. Vet Immunol Immunopathol. 2014;159:180-91 pubmed publisher
..Here, we confirm the current annotation of pig IFITM1, IFITM2, IFITM3, IFITM5, IFITM1L1 and IFITM1L4, manually annotated IFITM1L2, IFITM1L3, IFITM5L, IFITM3L1 and IFITM3L2, and ..
Xu J, Qian P, Wu Q, Liu S, Fan W, Zhang K, et al
. Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo. Antiviral Res. 2014;109:22-9 pubmed publisher
The interferon-induced transmembrane protein 3 (IFITM3) is a widely expressed potent antiviral effector of the host innate immune system. It restricts a diverse group of pathogenic, enveloped viruses, by interfering with endosomal fusion...
Zhang H, Zheng H, Qian P, Xu J, Yang X, Zhou R, et al
. Induction of systemic IFITM3 expression does not effectively control foot-and-mouth disease viral infection in transgenic pigs. Vet Microbiol. 2016;191:20-6 pubmed publisher
..Our previous study showed that overexpression of swine IFITM3 (sIFITM3) impeded replication of the FMD virus (FMDV) in BHK-21 cells and mice...