GJA1

Summary

Gene Symbol: GJA1
Description: gap junction protein, alpha 1, 43kDa
Alias: CX43, connexin 43, connexin-43, gap junction alpha-1 protein
Species: pig

Top Publications

  1. ncbi Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
    Junko Kamei
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 312:380-7. 2003
  2. ncbi Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells
    Christos E Chadjichristos
    Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland
    Circ Res 102:653-60. 2008
  3. ncbi Porcine aortic endothelial gap junctions: identification and permeation by caged InsP3
    T D Carter
    National Institute for Medical Research, London, UK
    J Cell Sci 109:1765-73. 1996
  4. ncbi Connexin43 orthologues in vertebrates: phylogeny from fish to man
    Marcel A G van der Heyden
    Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB, The Netherlands
    Dev Genes Evol 214:261-6. 2004
  5. ncbi Changes of connexin43 expression in non-pregnant porcine myometrium correlate with progesterone concentration during oestrous cycle
    J Karasinski
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 45:959-66. 2010
  6. ncbi Effects of pre- and postnatal exposure to flutamide on connexin 43 expression in testes and ovaries of prepubertal pigs
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Eur J Histochem 54:e15. 2010

Scientific Experts

  • J Karasinski
  • I Kopera
  • Christos E Chadjichristos
  • Marcel A G van der Heyden
  • Junko Kamei
  • B Bilinska
  • M Duda
  • A Hejmej
  • M Koziorowski
  • K Knapczyk-Stwora
  • M Durlej
  • M Slomczynska
  • Marie Luce Bochaton-Piallat
  • Jean Paul Derouette
  • Isabelle Roth
  • Jean-Paul Derouette
  • Anne C Brisset
  • Sandrine Morel
  • Esther Sutter
  • Brenda R Kwak
  • Marie-Luce Bochaton-Piallat
  • Jacques M T De Bakker
  • Tobias Opthof
  • Ronald Wilders
  • Marleen van Eijk
  • Masatsugu Hori
  • Toshihiko Toyofuku
  • T D Carter
  • E Kalapothakis
  • G Carlile
  • W H Evans
  • X Y Chen
  • D Ogden

Detail Information

Publications6

  1. ncbi Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
    Junko Kamei
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 312:380-7. 2003
    ..We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner...
  2. ncbi Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells
    Christos E Chadjichristos
    Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland
    Circ Res 102:653-60. 2008
    ..Cx40 was highly expressed in normal media of porcine coronary artery in vivo, whereas Cx43 was barely detectable...
  3. ncbi Porcine aortic endothelial gap junctions: identification and permeation by caged InsP3
    T D Carter
    National Institute for Medical Research, London, UK
    J Cell Sci 109:1765-73. 1996
    ..These results show that primary cultures of porcine aortic endothelial cells express connexin 37 and 43, and provide strong evidence that the second messenger molecule InsP3 can permeate porcine endothelial gap junctions...
  4. ncbi Connexin43 orthologues in vertebrates: phylogeny from fish to man
    Marcel A G van der Heyden
    Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB, The Netherlands
    Dev Genes Evol 214:261-6. 2004
    The gap junction protein connexin43 (Cx43) is widely expressed in all vertebrate species; however, in ventricular myocardium, Cx43 expression is restricted to mammalian species only, where it provides the molecular correlate for both ..
  5. ncbi Changes of connexin43 expression in non-pregnant porcine myometrium correlate with progesterone concentration during oestrous cycle
    J Karasinski
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 45:959-66. 2010
    Connexin43 (Cx43) is a major protein of myometrial gap junctions. The number of Cx43 gap junctions increase dramatically with the onset of labour in association with development of synchronized uterine contractions...
  6. ncbi Effects of pre- and postnatal exposure to flutamide on connexin 43 expression in testes and ovaries of prepubertal pigs
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Eur J Histochem 54:e15. 2010
    The aim of this study was to show whether the connexin43 (Cx43) expression in gonads is affected by an anti-androgen action...