GJA1

Summary

Gene Symbol: GJA1
Description: gap junction protein, alpha 1, 43kDa
Alias: CX43, connexin 43, connexin-43, gap junction alpha-1 protein
Species: pig

Top Publications

  1. ncbi Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
    Junko Kamei
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 312:380-7. 2003
  2. doi Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells
    Christos E Chadjichristos
    Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland
    Circ Res 102:653-60. 2008
  3. doi Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model
    Olympia Bikou
    Department of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Cardiovasc Res 92:218-25. 2011
  4. pmc Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction
    Ian D Greener
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Am Coll Cardiol 60:1103-10. 2012
  5. doi Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 46:1050-60. 2011
  6. ncbi [Changes in myocardial connexin 43 during ventricular fibrillation]
    Hong zhen Liu
    Department of Cardiology, Qilu Hospital Affiliated to Shandong University, Jinan 250012, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:595-8. 2010
  7. doi No-reflow disrupts the expression and distribution of connexin 43 in a swine model
    Yu tong Cheng
    Department of Cardiology, Fuwai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
    Microvasc Res 82:404-9. 2011
  8. ncbi Connexin43 orthologues in vertebrates: phylogeny from fish to man
    Marcel A G van der Heyden
    Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB, The Netherlands
    Dev Genes Evol 214:261-6. 2004
  9. doi Changes of connexin43 expression in non-pregnant porcine myometrium correlate with progesterone concentration during oestrous cycle
    J Karasinski
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 45:959-66. 2010
  10. ncbi Porcine aortic endothelial gap junctions: identification and permeation by caged InsP3
    T D Carter
    National Institute for Medical Research, London, UK
    J Cell Sci 109:1765-73. 1996

Scientific Experts

  • Olympia Bikou
  • J Karasinski
  • I Kopera
  • Ian D Greener
  • Yu tong Cheng
  • M Slomczynska
  • K Knapczyk-Stwora
  • A Hejmej
  • B Bilinska
  • M Durlej
  • M Duda
  • Hong zhen Liu
  • Christos E Chadjichristos
  • Marcel A G van der Heyden
  • Junko Kamei
  • J Kevin Donahue
  • Tetsuo Sasano
  • Maria Strom
  • Tomonori Igarashi
  • Xiaoping Wan
  • David S Rosenbaum
  • Jing lin Zhao
  • Xiang Dong Li
  • Yue jin Yang
  • Hai tao Zhang
  • Sheng Kang
  • Hai yan Qian
  • Jing Sha Li
  • Guo Ying Su
  • Jing Quan Zhong
  • Yun Zhang
  • Jing Wang
  • M Koziorowski
  • Isabelle Roth
  • Brenda R Kwak
  • Anne C Brisset
  • Sandrine Morel
  • Esther Sutter
  • Marie Luce Bochaton-Piallat
  • Jean Paul Derouette
  • Ronald Wilders
  • Jacques M T De Bakker
  • Marleen van Eijk
  • Tobias Opthof
  • Masatsugu Hori
  • Toshihiko Toyofuku
  • T D Carter
  • D Ogden
  • W H Evans
  • X Y Chen
  • E Kalapothakis
  • G Carlile

Detail Information

Publications11

  1. ncbi Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
    Junko Kamei
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 312:380-7. 2003
    ..We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner...
  2. doi Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells
    Christos E Chadjichristos
    Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland
    Circ Res 102:653-60. 2008
    ..Cx40 was highly expressed in normal media of porcine coronary artery in vivo, whereas Cx43 was barely detectable...
  3. doi Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model
    Olympia Bikou
    Department of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Cardiovasc Res 92:218-25. 2011
    ..We hypothesized that AF suppresses expression of the gap junction protein connexin (Cx) 43 and that Cx43 gene transfer to both atria would prevent persistent AF...
  4. pmc Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction
    Ian D Greener
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Am Coll Cardiol 60:1103-10. 2012
    The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycardia in a model of healed myocardial infarction.
  5. doi Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 46:1050-60. 2011
    ..androgen withdrawal caused by prenatal (GD20, GD80) or neonatal (PD2) exposure to an anti-androgen flutamide alters Cx43 gene expression and may induce delayed effects on morphology and function of adult pig testes...
  6. ncbi [Changes in myocardial connexin 43 during ventricular fibrillation]
    Hong zhen Liu
    Department of Cardiology, Qilu Hospital Affiliated to Shandong University, Jinan 250012, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:595-8. 2010
    To observe changes in connexin 43 (Cx43) after ventricular fibrillation (VF) and the effects of rotigaptide (ZP123) on Cx43.
  7. doi No-reflow disrupts the expression and distribution of connexin 43 in a swine model
    Yu tong Cheng
    Department of Cardiology, Fuwai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
    Microvasc Res 82:404-9. 2011
    Ischemia and ischemia/reperfusion can dephosphorylate and redistribute connexin 43 (Cx43). But it is unknown whether no-reflow phenomenon has an effect on the expression and distribution of Cx43 after acute infarction and reperfusion.
  8. ncbi Connexin43 orthologues in vertebrates: phylogeny from fish to man
    Marcel A G van der Heyden
    Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB, The Netherlands
    Dev Genes Evol 214:261-6. 2004
    The gap junction protein connexin43 (Cx43) is widely expressed in all vertebrate species; however, in ventricular myocardium, Cx43 expression is restricted to mammalian species only, where it provides the molecular correlate for both ..
  9. doi Changes of connexin43 expression in non-pregnant porcine myometrium correlate with progesterone concentration during oestrous cycle
    J Karasinski
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 45:959-66. 2010
    Connexin43 (Cx43) is a major protein of myometrial gap junctions. The number of Cx43 gap junctions increase dramatically with the onset of labour in association with development of synchronized uterine contractions...
  10. ncbi Porcine aortic endothelial gap junctions: identification and permeation by caged InsP3
    T D Carter
    National Institute for Medical Research, London, UK
    J Cell Sci 109:1765-73. 1996
    ..These results show that primary cultures of porcine aortic endothelial cells express connexin 37 and 43, and provide strong evidence that the second messenger molecule InsP3 can permeate porcine endothelial gap junctions...
  11. pmc Effects of pre- and postnatal exposure to flutamide on connexin 43 expression in testes and ovaries of prepubertal pigs
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Eur J Histochem 54:e15. 2010
    The aim of this study was to show whether the connexin43 (Cx43) expression in gonads is affected by an anti-androgen action...