FOXO1

Summary

Gene Symbol: FOXO1
Description: forkhead box O1
Alias: FOXO1A, forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, forkhead box O1A (rhabdomyosarcoma), forkhead/winged helix transcription factor FOXO1a
Species: pig
Products:     FOXO1

Top Publications

  1. Cunningham M, Zhu Q, Hammond J. FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells. Mol Endocrinol. 2004;18:1756-67 pubmed
    ..cells, which go through an exponential growth phase during development of the ovarian follicle, we find that FoxO1a is a key regulator of the G1/S transition in these cells...
  2. Yang Y, Pang W, Bai L, Yang G. [Expression of FoxO1 mRNA in muscle tissue of Bamei, Landrace and Landrace x Bamei]. Yi Chuan. 2008;30:185-9 pubmed
    ..The primers of pig FoxO1 were designed and synthesized according to its homologous sequences of human, chimpanzee and rat...
  3. Yuan Y, Shi X, Liu Y, Yang G. [Over-expression of FoxO1 inhibits the differentiation of porcine skeletal muscle myoblast]. Sheng Wu Gong Cheng Xue Bao. 2010;26:1668-73 pubmed
    The Forkhead box O1 (FoxO1) transcription factor governs muscle growth, metabolism and cell differentiation. However, its role in myoblast differentiation is unclear...
  4. Yan X, Weijun P, Ning W, Yu W, Wenkai R, Gongshe Y. Knockdown of both FoxO1 and C/EBP? promotes adipogenesis in porcine preadipocytes through feedback regulation. Cell Biol Int. 2013;37:905-16 pubmed publisher
    b>FoxO1 and C/EBP? are important transcription factors during adipogenic differentiation; however, the potential mechanisms of their inter-regulation in adipogenesis remain unknown...
  5. Lin F, Fu Y, Han J, Shen M, Du C, Li R, et al. Changes in the expression of Fox O1 and death ligand genes during follicular atresia in porcine ovary. Genet Mol Res. 2014;13:6638-45 pubmed publisher
    ..These results suggest Fox O1 involvement in the regulation of TRAIL and Fas L expression during follicular atresia in pigs. ..
  6. Shi X, Song Z, Yang Q, Liu Y, Yang G. Correlation of forkhead box transcription factor O1 and myosin heavy chain isoforms in porcine skeletal muscle. Genet Mol Res. 2014;13:10231-40 pubmed publisher
    We examined the expression of myosin heavy chain (MyHC) isoforms and forkhead box transcription factor O1 (FoxO1) in porcine soleus and extensor digitorum longus (EDL) muscles to clarify the correlation of FoxO1 and the relative ..
  7. Liu Y, Wang X, Wu H, Chen S, Zhu H, Zhang J, et al. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. Am J Physiol Regul Integr Comp Physiol. 2016;311:R365-73 pubmed publisher
    ..target of rapamycin (mTOR), eukaryotic initiation factor 4E binding protein 1 (4E-BP1), and Forkhead Box O 1 (FOXO1) in gastrocnemius or LD muscles...
  8. Andreucci M, Michael A, Kramers C, Park K, Chen A, Matthaeus T, et al. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 2003;64:1189-98 pubmed
    ..We conclude that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that Akt phosphorylation leads to phosphorylation of FKHR and FKHRL1, which may affect epithelial cell fate in acute renal failure. ..
  9. Pang W, Yu T, Bai L, Yang Y, Yang G. Tissue expression of porcine FoxO1 and its negative regulation during primary preadipocyte differentiation. Mol Biol Rep. 2009;36:165-76 pubmed publisher
    The Forkhead transcription factor O 1 (FoxO1) gene plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes clonal cell line differentiation...
  10. Dalmasso A, Goldish D, Benson B, Tsai A, Wasiluk K, Vercellotti G. Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury. J Biol Chem. 2014;289:838-47 pubmed publisher
    ..junction protein claudin-5 in porcine ECs through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm...

Detail Information

Publications12

  1. Cunningham M, Zhu Q, Hammond J. FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells. Mol Endocrinol. 2004;18:1756-67 pubmed
    ..cells, which go through an exponential growth phase during development of the ovarian follicle, we find that FoxO1a is a key regulator of the G1/S transition in these cells...
  2. Yang Y, Pang W, Bai L, Yang G. [Expression of FoxO1 mRNA in muscle tissue of Bamei, Landrace and Landrace x Bamei]. Yi Chuan. 2008;30:185-9 pubmed
    ..The primers of pig FoxO1 were designed and synthesized according to its homologous sequences of human, chimpanzee and rat...
  3. Yuan Y, Shi X, Liu Y, Yang G. [Over-expression of FoxO1 inhibits the differentiation of porcine skeletal muscle myoblast]. Sheng Wu Gong Cheng Xue Bao. 2010;26:1668-73 pubmed
    The Forkhead box O1 (FoxO1) transcription factor governs muscle growth, metabolism and cell differentiation. However, its role in myoblast differentiation is unclear...
  4. Yan X, Weijun P, Ning W, Yu W, Wenkai R, Gongshe Y. Knockdown of both FoxO1 and C/EBP? promotes adipogenesis in porcine preadipocytes through feedback regulation. Cell Biol Int. 2013;37:905-16 pubmed publisher
    b>FoxO1 and C/EBP? are important transcription factors during adipogenic differentiation; however, the potential mechanisms of their inter-regulation in adipogenesis remain unknown...
  5. Lin F, Fu Y, Han J, Shen M, Du C, Li R, et al. Changes in the expression of Fox O1 and death ligand genes during follicular atresia in porcine ovary. Genet Mol Res. 2014;13:6638-45 pubmed publisher
    ..These results suggest Fox O1 involvement in the regulation of TRAIL and Fas L expression during follicular atresia in pigs. ..
  6. Shi X, Song Z, Yang Q, Liu Y, Yang G. Correlation of forkhead box transcription factor O1 and myosin heavy chain isoforms in porcine skeletal muscle. Genet Mol Res. 2014;13:10231-40 pubmed publisher
    We examined the expression of myosin heavy chain (MyHC) isoforms and forkhead box transcription factor O1 (FoxO1) in porcine soleus and extensor digitorum longus (EDL) muscles to clarify the correlation of FoxO1 and the relative ..
  7. Liu Y, Wang X, Wu H, Chen S, Zhu H, Zhang J, et al. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. Am J Physiol Regul Integr Comp Physiol. 2016;311:R365-73 pubmed publisher
    ..target of rapamycin (mTOR), eukaryotic initiation factor 4E binding protein 1 (4E-BP1), and Forkhead Box O 1 (FOXO1) in gastrocnemius or LD muscles...
  8. Andreucci M, Michael A, Kramers C, Park K, Chen A, Matthaeus T, et al. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 2003;64:1189-98 pubmed
    ..We conclude that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that Akt phosphorylation leads to phosphorylation of FKHR and FKHRL1, which may affect epithelial cell fate in acute renal failure. ..
  9. Pang W, Yu T, Bai L, Yang Y, Yang G. Tissue expression of porcine FoxO1 and its negative regulation during primary preadipocyte differentiation. Mol Biol Rep. 2009;36:165-76 pubmed publisher
    The Forkhead transcription factor O 1 (FoxO1) gene plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes clonal cell line differentiation...
  10. Dalmasso A, Goldish D, Benson B, Tsai A, Wasiluk K, Vercellotti G. Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury. J Biol Chem. 2014;289:838-47 pubmed publisher
    ..junction protein claudin-5 in porcine ECs through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm...
  11. Dong P, Mai Y, Zhang Z, Mi L, Wu G, Chu G, et al. MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1. Acta Biochim Biophys Sin (Shanghai). 2014;46:565-71 pubmed publisher
    ..Target genes of miR-15a/b were predicted and examined, which revealed that Forkhead box protein O1 (FoxO1) is the target gene of miR-15a/b...
  12. Cao R, Wu W, Zhou X, Liu K, Li B, Huang X, et al. Let-7g induces granulosa cell apoptosis by targeting MAP3K1 in the porcine ovary. Int J Biochem Cell Biol. 2015;68:148-57 pubmed publisher
    ..In further studies, we found that overexpression of let-7g induced the expression of FoxO1 in GCs and led to nuclear accumulation of dephosphorylated FoxO1...