FABP4

Summary

Gene Symbol: FABP4
Description: fatty acid binding protein 4, adipocyte
Alias: A-FABP, AFABP, ALBP, AP2, FABP3, fatty acid-binding protein, adipocyte, adipocyte lipid-binding protein, adipocyte-type fatty acid-binding protein, fatty acid-binding protein 4
Species: pig

Top Publications

  1. Gerbens F, Jansen A, van Erp A, Harders F, Meuwissen T, Rettenberger G, et al. The adipocyte fatty acid-binding protein locus: characterization and association with intramuscular fat content in pigs. Mamm Genome. 1998;9:1022-6 pubmed
    The porcine A-FABP gene (FABP4) was isolated and sequenced to study the role of A-FABP in the differentiation of intramuscular fat (IMF) accretion in pigs...
  2. Ding S, McNeel R, Mersmann H. Expression of porcine adipocyte transcripts: tissue distribution and differentiation in vitro and in vivo. Comp Biochem Physiol B Biochem Mol Biol. 1999;123:307-18 pubmed
    ..adipocyte-characteristic protein transcripts (lipoprotein lipase (LPL) and adipocyte fatty acid binding protein (aP2)) were measured in pig tissues...
  3. Damon M, Louveau I, Lefaucheur L, Lebret B, Vincent A, Leroy P, et al. Number of intramuscular adipocytes and fatty acid binding protein-4 content are significant indicators of intramuscular fat level in crossbred Large White x Duroc pigs. J Anim Sci. 2006;84:1083-92 pubmed
    ..49). The current study suggests that FABP-4 protein content may be a valuable marker of lipid accretion in LM and that i.m. fat content and myofiber type composition can be manipulated independently. ..
  4. Gao Y, Zhang Y, Zhang S, Li F, Wang S, Dai L, et al. Association of A-FABP gene polymorphism in intron 1 with meat quality traits in Junmu No. 1 white swine. Gene. 2011;487:170-3 pubmed publisher
    ..Expression was markedly reduced in DD compared with genotype CC. Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits. ..
  5. Chen Q, Wang H, Zeng Y, Chen W. Developmental changes and effect on intramuscular fat content of H-FABP and A-FABP mRNA expression in pigs. J Appl Genet. 2013;54:119-23 pubmed publisher
    ..05). In conclusion, the A-FABP gene is strongly related to the development and function of IMF accretion in pigs. ..
  6. Ballester M, Puig Oliveras A, Castello A, Revilla M, Fernandez A, Folch J. Association of genetic variants and expression levels of porcine FABP4 and FABP5 genes. Anim Genet. 2017;48:660-668 pubmed publisher
    The FABP4 and FABP5 genes, coding for fatty acid transport proteins, have long been studied as positional candidate genes for SSC4 QTL affecting fat deposition and composition traits in pigs. Polymorphisms in these genes, FABP4:g...
  7. Armstrong M, Bernlohr D, Storch J, Clarke S. The purification and characterization of a fatty acid binding protein specific to pig (Sus domesticus) adipose tissue. Biochem J. 1990;267:373-8 pubmed
    ..0 microM. Northern-blot analysis using the cDNA for the murine 3T3-L1 FABP revealed that the pig a-FABP was expressed exclusively in adipose tissue. ..
  8. Monbaliu D, de Vries B, Crabbe T, van Heurn E, Verwaest C, Roskams T, et al. Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors. Transplant Proc. 2005;37:413-6 pubmed
    ..Monitoring of posttransplant L-FABP plasma levels is a valuable new tool to quantify early the extent of parenchymal cell damage of NHBD livers and to predict their viability and function. ..
  9. Ojeda A, Rozas J, Folch J, Perez Enciso M. Unexpected high polymorphism at the FABP4 gene unveils a complex history for pig populations. Genetics. 2006;174:2119-27 pubmed
    Fatty acid bing protein 4 (FABP4) plays a key role in fat regulation in mammals and is a strong positional candidate gene for the FAT1 quantitative trait locus located on porcine chromosome 4...
  10. Lee M, Tse H, Siu C, Zhu S, Man R, Vanhoutte P. Genomic changes in regenerated porcine coronary arterial endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:2443-9 pubmed
    ..Cultures from regenerated coronary endothelial cells exhibit genomic changes explaining endothelial dysfunction and suggesting facilitation of coagulation, lipid peroxidation, and extracellular matrix remodeling. ..

Detail Information

Publications11

  1. Gerbens F, Jansen A, van Erp A, Harders F, Meuwissen T, Rettenberger G, et al. The adipocyte fatty acid-binding protein locus: characterization and association with intramuscular fat content in pigs. Mamm Genome. 1998;9:1022-6 pubmed
    The porcine A-FABP gene (FABP4) was isolated and sequenced to study the role of A-FABP in the differentiation of intramuscular fat (IMF) accretion in pigs...
  2. Ding S, McNeel R, Mersmann H. Expression of porcine adipocyte transcripts: tissue distribution and differentiation in vitro and in vivo. Comp Biochem Physiol B Biochem Mol Biol. 1999;123:307-18 pubmed
    ..adipocyte-characteristic protein transcripts (lipoprotein lipase (LPL) and adipocyte fatty acid binding protein (aP2)) were measured in pig tissues...
  3. Damon M, Louveau I, Lefaucheur L, Lebret B, Vincent A, Leroy P, et al. Number of intramuscular adipocytes and fatty acid binding protein-4 content are significant indicators of intramuscular fat level in crossbred Large White x Duroc pigs. J Anim Sci. 2006;84:1083-92 pubmed
    ..49). The current study suggests that FABP-4 protein content may be a valuable marker of lipid accretion in LM and that i.m. fat content and myofiber type composition can be manipulated independently. ..
  4. Gao Y, Zhang Y, Zhang S, Li F, Wang S, Dai L, et al. Association of A-FABP gene polymorphism in intron 1 with meat quality traits in Junmu No. 1 white swine. Gene. 2011;487:170-3 pubmed publisher
    ..Expression was markedly reduced in DD compared with genotype CC. Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits. ..
  5. Chen Q, Wang H, Zeng Y, Chen W. Developmental changes and effect on intramuscular fat content of H-FABP and A-FABP mRNA expression in pigs. J Appl Genet. 2013;54:119-23 pubmed publisher
    ..05). In conclusion, the A-FABP gene is strongly related to the development and function of IMF accretion in pigs. ..
  6. Ballester M, Puig Oliveras A, Castello A, Revilla M, Fernandez A, Folch J. Association of genetic variants and expression levels of porcine FABP4 and FABP5 genes. Anim Genet. 2017;48:660-668 pubmed publisher
    The FABP4 and FABP5 genes, coding for fatty acid transport proteins, have long been studied as positional candidate genes for SSC4 QTL affecting fat deposition and composition traits in pigs. Polymorphisms in these genes, FABP4:g...
  7. Armstrong M, Bernlohr D, Storch J, Clarke S. The purification and characterization of a fatty acid binding protein specific to pig (Sus domesticus) adipose tissue. Biochem J. 1990;267:373-8 pubmed
    ..0 microM. Northern-blot analysis using the cDNA for the murine 3T3-L1 FABP revealed that the pig a-FABP was expressed exclusively in adipose tissue. ..
  8. Monbaliu D, de Vries B, Crabbe T, van Heurn E, Verwaest C, Roskams T, et al. Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors. Transplant Proc. 2005;37:413-6 pubmed
    ..Monitoring of posttransplant L-FABP plasma levels is a valuable new tool to quantify early the extent of parenchymal cell damage of NHBD livers and to predict their viability and function. ..
  9. Ojeda A, Rozas J, Folch J, Perez Enciso M. Unexpected high polymorphism at the FABP4 gene unveils a complex history for pig populations. Genetics. 2006;174:2119-27 pubmed
    Fatty acid bing protein 4 (FABP4) plays a key role in fat regulation in mammals and is a strong positional candidate gene for the FAT1 quantitative trait locus located on porcine chromosome 4...
  10. Lee M, Tse H, Siu C, Zhu S, Man R, Vanhoutte P. Genomic changes in regenerated porcine coronary arterial endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:2443-9 pubmed
    ..Cultures from regenerated coronary endothelial cells exhibit genomic changes explaining endothelial dysfunction and suggesting facilitation of coagulation, lipid peroxidation, and extracellular matrix remodeling. ..
  11. Lu L, Wang Y, Sun W, Liu Z, Zhang Q, Pu L, et al. Two-dimensional fluorescence in-gel electrophoresis of coronary restenosis tissues in minipigs: increased adipocyte fatty acid binding protein induces reactive oxygen species-mediated growth and migration in smooth muscle cells. Arterioscler Thromb Vasc Biol. 2013;33:572-80 pubmed publisher
    ..to investigate the influences of crucial proteins identified, particularly adipocyte fatty acid binding protein (AFABP), in human arterial smooth muscle cells...