Gene Symbol: DUOX2
Description: dual oxidase 2
Alias: dual oxidase 2, NADH/NADPH thyroid oxidase p138-tox
Morand S, Chaaraoui M, Kaniewski J, Dème D, Ohayon R, Noel Hudson M, et al
. Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. Endocrinology. 2003;144:1241-8 pubmed
..is a calcium-dependent nicotinamide adenine dinucleotide phosphate (NADPH) oxidase involving the flavoprotein Duox2. NADPH oxidase activity and Duox2 require cAMP to be expressed in pig thyrocytes...
Dupuy C, Ohayon R, Valent A, Noël Hudson M, Deme D, Virion A. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem. 1999;274:37265-9 pubmed
..The gene of human p138(Tox) has been localized on chromosome 15q15. ..
El Hassani R, Benfares N, Caillou B, Talbot M, Sabourin J, Belotte V, et al
. Dual oxidase2 is expressed all along the digestive tract. Am J Physiol Gastrointest Liver Physiol. 2005;288:G933-42 pubmed
..b>DUOX2 mRNA was recently detected by RT-PCR and in-situ hybridization experiments in other tissues, such as rat colon and ..
Morand S, Dos Santos O, Ohayon R, Kaniewski J, Noel Hudson M, Virion A, et al
. Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes. Endocrinology. 2003;144:567-74 pubmed
The Duox2 flavoprotein is strongly expressed in the thyroid gland, where it plays a critical role in the synthesis of thyroid hormones likely by providing thyroperoxidase with H(2)O(2)...
Morand S, Agnandji D, Noel Hudson M, Nicolas V, Buisson S, Macon Lemaitre L, et al
. Targeting of the dual oxidase 2 N-terminal region to the plasma membrane. J Biol Chem. 2004;279:30244-51 pubmed
b>Dual oxidase 2 (Duox2) is a cell surface glycoprotein that probably provides thyroperoxidase with the H2O2 required to catalyze thyroid hormone synthesis...
Ameziane El Hassani R, Morand S, Boucher J, Frapart Y, Apostolou D, Agnandji D, et al
. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. J Biol Chem. 2005;280:30046-54 pubmed
b>Duox2 (and probably Duox1) is a glycoflavoprotein involved in thyroid hormone biosynthesis, as the thyroid H2O2 generator functionally associated with Tpo (thyroperoxidase)...
Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, et al
. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017;130:2161-2170 pubmed publisher
..A novel recessive c.1226A>G transition of the dual oxidase 2 (DUOX2) gene was identified as the causative mutation...