Gene Symbol: DLK1
Description: delta like non-canonical Notch ligand 1
Alias: Pref-1, protein delta homolog 1, delta-like 1 homolog, delta-like 1 protein
Kim K, Kim J, Dekkers J, Rothschild M. Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs. Mamm Genome. 2004;15:552-9 pubmed
..The callipyge locus (CLPG) maps to the distal portion of ovine Chromosome 18 within the DLK1- GTL2 region and corresponds to human Chromosome 14q32, where uniparental disomy (UPD) of the region is associated ..
Deiuliis J, Li B, Lyvers Peffer P, Moeller S, Lee K. Alternative splicing of delta-like 1 homolog (DLK1) in the pig and human. Comp Biochem Physiol B Biochem Mol Biol. 2006;145:50-9 pubmed
Delta-like homolog 1 (DLK1), a paternally imprinted gene with several alternative splicing isoforms, is an important regulator of fetal and postnatal development...
Li X, Do K, Kim J, Huang J, Zhao S, Lee Y, et al
. Molecular characteristics of the porcine DLK1 and MEG3 genes. Anim Genet. 2008;39:189-92 pubmed publisher
Imprinted genes play important roles in embryo survival and postnatal growth regulation. The DLK1 and MEG3 (previously GTL2) genes are linked and reciprocally imprinted in several mammals, but their imprinting status is still unknown in ..
Bischoff S, Tsai S, Hardison N, Motsinger Reif A, Freking B, Nonneman D, et al
. Characterization of conserved and nonconserved imprinted genes in swine. Biol Reprod. 2009;81:906-20 pubmed publisher
..Imprinting was confirmed for DIRAS3, DLK1, H19, IGF2AS, NNAT, MEST, PEG10, PHLDA2, PLAGL1, SGCE, and SNORD107...
Oczkowicz M, Ropka Molik K, Piórkowska K, Rozycki M, Rejduch B. Frequency of DLK1 c.639C>T polymorphism and the analysis of MEG3/DLK1/PEG11 cluster expression in muscle of swine raised in Poland. Meat Sci. 2011;88:627-30 pubmed publisher
b>DLK1--(Drosophila like element 1) is a paternally expressed gene, associated with the callipyge phenotype in sheep...
Lahbib Mansais Y, Barasc H, Marti Marimon M, Mompart F, Iannuccelli E, Robelin D, et al
. Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells. BMC Cell Biol. 2016;17:35 pubmed
..e. SLC38A4, DLK1, MEG3, and ZAC1)...
Samulin J, Berg P, Sundvold H, Grindflek E, Lien S. Expression of DLK1 splice variants during porcine adipocyte development in vitro and in vivo. Anim Genet. 2009;40:239-41 pubmed publisher
Delta-like 1 (DLK1) belongs to the epidermal growth factor-like transmembrane protein family and is involved in the regulation of adipogenesis...