Gene Symbol: CMAH
Description: cytidine monophosphate-N-acetylneuraminic acid hydroxylase
Alias: cytidine monophosphate-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminate monooxygenase, CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase
Burlak C, Bern M, Brito A, Isailovic D, Wang Z, Estrada J, et al
. N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens. Xenotransplantation. 2013;20:277-91 pubmed publisher
..pigs deficient in galactose ?1,3 galactose (gene modified: GGTA1) and N-glycolylneuraminic acid (gene modified: CMAH) have significantly improved cell survival when challenged by human antibody and complement in vitro...
Butler J, Paris L, Blankenship R, Sidner R, Martens G, Ladowski J, et al
. Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers. Transplantation. 2016;100:571-6 pubmed publisher
..Inactivating GGTA1 and CMAH genes has reduced the antibody-mediated barrier to xenotransplantation; herein, we describe the effect that these ..
Butler J, Martens G, Estrada J, Reyes L, Ladowski J, Galli C, et al
. Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. Transgenic Res. 2016;25:751-9 pubmed publisher
..Pigs doubly deficient in GGTA1 and CMAH genes were compared to pigs of the same background that expressed a human complement regulatory protein (hCRP)...
Martens G, Reyes L, Li P, Butler J, Ladowski J, Estrada J, et al
. Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs. Transplantation. 2017;101:e86-e92 pubmed publisher
..WT), ?1, 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) KO, and GGTA1/ CMAH /b1,4 N-acetylgalactosaminyl transferase (B4GalNT2) KO pigs were screened for human antibody ..
Schlenzka W, Shaw L, Kelm S, Schmidt C, Bill E, Trautwein A, et al
. CMP-N-acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron-sulphur protein to be described in Eukarya. FEBS Lett. 1996;385:197-200 pubmed
..Furthermore, possible binding sites for cytochrome b5, the substrate CMP-Neu5Ac and a mononuclear iron centre were also identified. ..
Song K, Kang Y, Jin U, Park Y, Kim S, Seong H, et al
. Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation. Biochem J. 2010;427:179-88 pubmed publisher
..From the results, it was concluded that the pcmah gene was capable of synthesizing the NeuGc acting as a xenoantigen in humans, confirming the NeuGc-mediated rejection response in pig-human xenotransplantation. ..
Ikeda K, Yamamoto A, Nanjo A, Inuinaka C, Takama Y, Ueno T, et al
. A cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells. Transplant Proc. 2012;44:1136-8 pubmed publisher
..The expression of NeuGc is controlled by the activity of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH). In this study, molecular cloning of pig CMAH was performed, as the first step in producing H-D knockout pigs...