Genomes and Genes




Gene Symbol: CD74
Description: CD74 molecule
Alias: CD74 antigen, CD74 molecule, major histocompatibility complex, class II invariant chain
Species: pig

Top Publications

  1. Zhang H, Liu C, Cheng S, Wang X, Li W, Charreyre C, et al. Porcine CD74 is involved in the inflammatory response activated by nuclear factor kappa B during porcine circovirus type 2 (PCV-2) infection. Arch Virol. 2013;158:2285-95 pubmed publisher
    Human CD74 induces a signalling cascade that results in the activation of nuclear factor kappa B (NF-?B); however, porcine CD74 has not been widely studied...
  2. Liu W, Xu F. [Effect of the targeted mutation of sorting motifs on the localization of porcine Ia-associated invariant chain]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014;30:925-8 pubmed
    ..pig Ii comprises two independent sorting signals, and the functional Leu-based sorting signal requires specific neighboring residues. ..
  3. Xu F, Dai Y, Li L, Ding X, Yu W. Molecular cloning and site-directed mutagenesis of leucine-based sorting motifs of the porcine invariant chain. Genet Mol Res. 2013;12:4489-99 pubmed publisher
    ..Based on observations with the fluorescent microscope, we found that two leucine-based motifs are required for pig Ii intracellular localization, and that both motifs independently mediate this function in Ii. ..
  4. Xu F, Wu S, Yu W. Intracellular localization and association of MHC class I with porcine invariant chain. Genet Mol Res. 2013;12:693-701 pubmed publisher
    ..The Ii of CLIP plays a key role in assembly of Ii and MHC I. ..