Gene Symbol: ATP1B1
Description: ATPase Na+/K+ transporting subunit beta 1
Alias: sodium/potassium-transporting ATPase subunit beta-1, ATPase, Na+/K+ transporting, beta 1 polypeptide, Na+, K+-ATPase beta-subunit, sodium/potassium-dependent ATPase subunit beta-1
Species: pig
Products:     ATP1B1

Top Publications

  1. Lahbib Mansais Y, Yerle M, Dalens M, Chevalet C, Gellin J. Localization of pig Na+,K(+)-ATPase alpha and beta subunit genes to chromosome 4 by radioactive in situ hybridization. Genomics. 1993;15:91-7 pubmed
    ..We showed that the pig cDNA probes encoding ATPase alpha and beta genes reveal DNA polymorphism in Meishan and Large White pigs. ..
  2. Figtree G, Liu C, Bibert S, Hamilton E, Garcia A, White C, et al. Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009;105:185-93 pubmed publisher
    ..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
  3. Ovchinnikov YuA -, Modyanov N, Broude N, Petrukhin K, Grishin A, Arzamazova N, et al. Pig kidney Na+,K+-ATPase. Primary structure and spatial organization. FEBS Lett. 1986;201:237-45 pubmed
    ..Structural data on the peptides from extramembrane regions of the alpha-subunit and on glycopeptides of the beta-subunit underlie a model for the transmembrane arrangement of Na+,K+-ATPase polypeptide chains. ..
  4. Belogus T, Haviv H, Karlish S. Neutralization of the charge on Asp 369 of Na+,K+-ATPase triggers E1 <--> E2 conformational changes. J Biol Chem. 2009;284:31038-51 pubmed publisher
    ..Changes in charge interactions of Asp(369) may play an important role in triggering E(1)P(3Na) <--> E(2)P and E(2)(2K) --> E(1)Na transitions in native Na(+),K(+)-ATPase. ..
  5. Kanai R, Ogawa H, Vilsen B, Cornelius F, Toyoshima C. Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state. Nature. 2013;502:201-6 pubmed publisher
    ..A mechanism for sequential, cooperative Na(+) binding can now be formulated in atomic detail. ..
  6. Ovchinnikov YuA -, Arzamazova N, Arystarkhova E, Gevondyan N, Aldanova N, Modyanov N. Detailed structural analysis of exposed domains of membrane-bound Na+,K+-ATPase. A model of transmembrane arrangement. FEBS Lett. 1987;217:269-74 pubmed
    ..A model for the spatial organisation of the enzyme in the membrane was proposed on the basis of detailed structural analysis of extramembrane regions of both subunits. ..
  7. Yerle M, Lahbib Mansais Y, Pinton P, Robic A, Goureau A, Milan D, et al. The cytogenetic map of the domestic pig. Mamm Genome. 1997;8:592-607 pubmed
  8. Morth J, Pedersen B, Toustrup Jensen M, Sørensen T, Petersen J, Andersen J, et al. Crystal structure of the sodium-potassium pump. Nature. 2007;450:1043-9 pubmed
    ..The carboxy terminus of the alpha-subunit is contained within a pocket between transmembrane helices and seems to be a novel regulatory element controlling sodium affinity, possibly influenced by the membrane potential. ..
  9. Broude N, Monastyrskaia G, Petrukhin K, Grishin A, Kiiatkin N. [Primary structure of the beta-subunit of Na+,K+-ATPase from the swine kidney. II. Reverse transcription, cloning of mRNA, complete nucleotide sequence corresponding to the structural region of the gene]. Bioorg Khim. 1987;13:14-9 pubmed
    ..The beta-subunit contains 302 amino acid residues and the protein is not processed at the N-nor at the C-terminus. ..

More Information


  1. Rajasekaran S, HUYNH T, Wolle D, Espineda C, INGE L, Skay A, et al. Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis. Mol Cancer Ther. 2010;9:1515-24 pubmed publisher
    ..These findings reveal for the first time that Na,K-ATPase is a target of TGF-beta(1)-mediated EMT and is associated with the progression of EMT in cancer and fibrosis...
  2. Yatime L, Laursen M, Morth J, Esmann M, Nissen P, Fedosova N. Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase. J Struct Biol. 2011;174:296-306 pubmed publisher
    ..The observed re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks...