F

Summary

Gene Symbol: F
Description: fusion protein
Species: Newcastle disease virus B1

Top Publications

  1. Cornax I, Diel D, Rue C, Estevez C, Yu Q, Miller P, et al. Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. J Gen Virol. 2013;94:1189-1194 pubmed publisher
    The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection...
  2. Samal S, Khattar S, Kumar S, Collins P, Samal S. Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity. J Virol. 2012;86:2501-11 pubmed publisher
    The role of N-linked glycosylation of the Newcastle disease virus (NDV) fusion (F) protein in viral replication and pathogenesis was examined by eliminating potential acceptor sites using a reverse genetics system for the moderately ..
  3. Ayll n J, Villar E, Mu oz Barroso I. Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype. J Virol. 2010;84:1066-75 pubmed publisher
    ..viruses into host cells is preceded by membrane fusion, which in paramyxoviruses is triggered by the fusion (F) protein...
  4. Laliberte J, McGinnes L, Morrison T. Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity. J Virol. 2007;81:10636-48 pubmed publisher
    ..fusion capacity of particles released from cholesterol-extracted cells correlated with significant loss of HN-F glycoprotein-containing complexes detected in the virion envelopes of these particles and with detection of cell-..
  5. Kim S, Wanasen N, Paldurai A, Xiao S, Collins P, Samal S. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS ONE. 2013;8:e74022 pubmed publisher
    ..vaccines, a full-genome reverse genetics system has been used to generate a recombinant virus in which the F protein cleavage site has been changed to that of avirulent vaccine virus...
  6. Qin Z, Xu H, Ouyang W, Wang Y, Wang L, Yuan X, et al. [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]. Wei Sheng Wu Xue Bao. 2008;48:226-33 pubmed
    ..Sequence analysis based on the variable region (nucleotide 47-420) of the F gene indicated that of the 13 NDV isolates 2 belonged to genotype II, 2 to genotype IX and 9 to genotype VII...
  7. Swanson K, Wen X, Leser G, Paterson R, Lamb R, Jardetzky T. Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology. 2010;402:372-9 pubmed publisher
    The paramyxovirus F protein is a class I viral membrane fusion protein which undergoes a significant refolding transition during virus entry...
  8. Kumar C, Kumar S. Species based synonymous codon usage in fusion protein gene of Newcastle disease virus. PLoS ONE. 2014;9:e114754 pubmed publisher
    ..The NDV fusion protein (F) is a major determinant of its pathogenicity and virulence...
  9. Gravel K, McGinnes L, Reitter J, Morrison T. The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol. 2011;85:3486-97 pubmed publisher
    The role of specific sequences in the transmembrane (TM) domain of Newcastle disease virus (NDV) fusion (F) protein in the structure and function of this protein was assessed by replacing this domain with the F protein TM domains from ..
  10. Mahon P, Mirza A, Iorio R. Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion. J Virol. 2011;85:12079-82 pubmed publisher
    ..membrane fusion requires an interaction between the hemagglutinin-neuraminidase (HN) attachment and the fusion (F) proteins, triggered by HN's binding to receptors...

Detail Information

Publications18

  1. Cornax I, Diel D, Rue C, Estevez C, Yu Q, Miller P, et al. Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. J Gen Virol. 2013;94:1189-1194 pubmed publisher
    The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection...
  2. Samal S, Khattar S, Kumar S, Collins P, Samal S. Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity. J Virol. 2012;86:2501-11 pubmed publisher
    The role of N-linked glycosylation of the Newcastle disease virus (NDV) fusion (F) protein in viral replication and pathogenesis was examined by eliminating potential acceptor sites using a reverse genetics system for the moderately ..
  3. Ayll n J, Villar E, Mu oz Barroso I. Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype. J Virol. 2010;84:1066-75 pubmed publisher
    ..viruses into host cells is preceded by membrane fusion, which in paramyxoviruses is triggered by the fusion (F) protein...
  4. Laliberte J, McGinnes L, Morrison T. Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity. J Virol. 2007;81:10636-48 pubmed publisher
    ..fusion capacity of particles released from cholesterol-extracted cells correlated with significant loss of HN-F glycoprotein-containing complexes detected in the virion envelopes of these particles and with detection of cell-..
  5. Kim S, Wanasen N, Paldurai A, Xiao S, Collins P, Samal S. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS ONE. 2013;8:e74022 pubmed publisher
    ..vaccines, a full-genome reverse genetics system has been used to generate a recombinant virus in which the F protein cleavage site has been changed to that of avirulent vaccine virus...
  6. Qin Z, Xu H, Ouyang W, Wang Y, Wang L, Yuan X, et al. [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]. Wei Sheng Wu Xue Bao. 2008;48:226-33 pubmed
    ..Sequence analysis based on the variable region (nucleotide 47-420) of the F gene indicated that of the 13 NDV isolates 2 belonged to genotype II, 2 to genotype IX and 9 to genotype VII...
  7. Swanson K, Wen X, Leser G, Paterson R, Lamb R, Jardetzky T. Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology. 2010;402:372-9 pubmed publisher
    The paramyxovirus F protein is a class I viral membrane fusion protein which undergoes a significant refolding transition during virus entry...
  8. Kumar C, Kumar S. Species based synonymous codon usage in fusion protein gene of Newcastle disease virus. PLoS ONE. 2014;9:e114754 pubmed publisher
    ..The NDV fusion protein (F) is a major determinant of its pathogenicity and virulence...
  9. Gravel K, McGinnes L, Reitter J, Morrison T. The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol. 2011;85:3486-97 pubmed publisher
    The role of specific sequences in the transmembrane (TM) domain of Newcastle disease virus (NDV) fusion (F) protein in the structure and function of this protein was assessed by replacing this domain with the F protein TM domains from ..
  10. Mahon P, Mirza A, Iorio R. Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion. J Virol. 2011;85:12079-82 pubmed publisher
    ..membrane fusion requires an interaction between the hemagglutinin-neuraminidase (HN) attachment and the fusion (F) proteins, triggered by HN's binding to receptors...
  11. Tsunekuni R, Ito H, Otsuki K, Kida H, Ito T. Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants. Virus Genes. 2010;40:252-5 pubmed publisher
    ..Seven amino acid substitutions were detected in the M, F, and HN proteins...
  12. McGinnes L, Morrison T. Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes. J Virol. 2006;80:2894-903 pubmed publisher
    Receptor binding of paramyxovirus attachment proteins and the interactions between attachment and fusion (F) proteins are thought to be central to activation of the F protein activity; however, mechanisms involved are unclear...
  13. Jain S, McGinnes L, Morrison T. Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein. J Virol. 2007;81:2328-39 pubmed publisher
    ..sialic acid-containing receptors, followed by fusion of viral and cell membranes, which is mediated by the fusion (F) protein...
  14. Qin Z, Ma B, He Y, Wang Y, Cui Z. [Newcastle disease virus heredity mutation and correlation of HN and F gene]. Wei Sheng Wu Xue Bao. 2006;46:227-32 pubmed
    ..These isolates were purified by CEF plaque assay and replicated in SPF embryos. The fusion protein (F) gene and hemagglutinin-neuraminidase (HN) gene of these isolated viruses were cloned and sequenced...
  15. Bose S, Song A, Jardetzky T, Lamb R. Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells. J Virol. 2014;88:3925-41 pubmed publisher
    ..Two viral integral membrane glycoproteins (fusion [F] and attachment [HN, H, or G]) mediate a concerted process of host receptor recognition, followed by the fusion of ..
  16. Mirza A, Iorio R. A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation. J Virol. 2013;87:8813-5 pubmed publisher
    ..membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins...
  17. Jain S, McGinnes L, Morrison T. Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein. J Virol. 2008;82:12039-48 pubmed publisher
    Newcastle disease virus (NDV) fusion (F) protein directs membrane fusion, which is required for virus entry and cell-cell fusion...