Gene Symbol: NMB1669
Description: heme utilisation protein
Species: Neisseria meningitidis MC58

Top Publications

  1. Kahler C, Blum E, Miller Y, Ryan D, Popovic T, Stephens D. exl, an exchangeable genetic island in Neisseria meningitidis. Infect Immun. 2001;69:1687-96 pubmed publisher
    ..The structure of these cassettes and their correlation with clonal groups emphasize the extensive gene pool and frequent horizontal DNA transfer events that contribute to the evolution and virulence of N. meningitidis...
  2. Schuller D, Zhu W, Stojiljkovic I, Wilks A, Poulos T. Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1. Biochemistry. 2001;40:11552-8 pubmed
    ..Key glycine residues provide the flexibility for the helical kink, allow close contact of the helix backbone with the heme, and may interact directly with heme ligands...
  3. Friedman J, Lad L, Deshmukh R, Li H, Wilks A, Poulos T. Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation. J Biol Chem. 2003;278:34654-9 pubmed
    ..Although the active site residues differ between nm-HO and human HO-1, the close similarity in the H-bonded water network suggests a common mechanism shared by all heme oxygenases. ..