Gene Symbol: ND3
Description: NADH dehydrogenase subunit 3
Green R, Malaspinas A, Krause J, Briggs A, Johnson P, Uhler C, et al
. A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell. 2008;134:416-26 pubmed publisher
..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
Czarnecka A, Krawczyk T, Zdrozny M, Lubi ski J, Arnold R, Kukwa W, et al
. Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland. Breast Cancer Res Treat. 2010;121:511-8 pubmed publisher
..This difference is highly statistically significant (P = 0.0008). It is therefore possible that the 10398G SNP constitutes an inherited predisposition factor for the development of breast cancer...
Tokutomi T, Takada Y, Murayama T, Mukaida M, Kanetake J. Real-time PCR method for identification of Asian populations in forensic casework. Leg Med (Tokyo). 2009;11 Suppl 1:S106-8 pubmed publisher
..740 for these SNPs in the Asian population. ..
Kumar M, Pathak D, Kriplani A, Ammini A, Talwar P, Dada R. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency. Arch Gynecol Obstet. 2010;282:695-705 pubmed publisher
Pezzotti A, Kraft P, Hankinson S, Hunter D, Buring J, Cox D. The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. PLoS ONE. 2009;4:e5356 pubmed publisher
Kishida K, Tominaga M, Matsubara K, Taguchi M, Noguchi M, Tsunawake N, et al
. An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults. PLoS ONE. 2009;4:e7763 pubmed publisher
..Further studies involving a larger sample size or other ethnic groups are necessary to confirm that mtDNA A10398G polymorphism can be a genetic factor for temperament. ..
Alsbeih G, Al Harbi N, El Sebaie M, Al Rajhi N, Al Hadyan K, Abu Amero K. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. Clin Cancer Res. 2009;15:7352-60 pubmed publisher
..The nonsynonymous A10398G variation in the ND3 gene was significantly associated with fibrotic reaction (P = 0.01)...
Nishigaki Y, Ueno H, Coku J, Koga Y, Fujii T, Sahashi K, et al
. Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations. Mitochondrion. 2010;10:300-8 pubmed publisher
..TV, -ND1, -TQ, -TW, -TC, and -TH genes; 2 each in MT-TN, -TG, -ND4, -TL2, -TE, and -CYB genes; 3 each in MT-ATP6, -ND3, and -ND5 genes; 4 each in MT-CO1 and -TK genes; 5 each in MT-TI, -TS1, and -ND6 genes; and 10 in the MT-TL1 gene...
Simon D, Pankratz N, Kissell D, Pauciulo M, Halter C, Rudolph A, et al
. Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease. BMC Med Genet. 2010;11:53 pubmed publisher
..However, these data do not exclude a role for mtDNA variants in other populations, and it remains possible that other inherited mitochondrial DNA variants, or somatic mDNA mutations, contribute to the risk of familial PD...