Gene Symbol: CYTB
Description: cytochrome b
Green R, Malaspinas A, Krause J, Briggs A, Johnson P, Uhler C, et al
. A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell. 2008;134:416-26 pubmed publisher
..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
Kaare M, G tz A, Ulander V, Ariansen S, Kaaja R, Suomalainen A, et al
. Do mitochondrial mutations cause recurrent miscarriage?. Mol Hum Reprod. 2009;15:295-300 pubmed publisher
..In addition, none of the detected variations were previously known to be pathogenic and therefore they are an unlikely cause of miscarriage...
Alsbeih G, Al Harbi N, El Sebaie M, Al Rajhi N, Al Hadyan K, Abu Amero K. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. Clin Cancer Res. 2009;15:7352-60 pubmed publisher
..Predictive markers of radiosensitivity should take into account mtDNA genetic variations in addition to variations in nuclear genes...
Nishigaki Y, Ueno H, Coku J, Koga Y, Fujii T, Sahashi K, et al
. Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations. Mitochondrion. 2010;10:300-8 pubmed publisher
..This genetic screening platform is useful to reach a definitive diagnosis for mitochondrial diseases...
Luo Y, Tang S, Gao W, Chen L, Yang X, Huang T, et al
. Genotyping mitochondrial DNA single nucleotide polymorphisms by PCR ligase detection reactions. Clin Chem Lab Med. 2010;48:475-83 pubmed publisher
..The PCR-LDR mtDNA genotyping technique is simple, highly accurate, has high-throughput, and is cost-effective. Therefore, this method is applicable to mtDNA haplotyping in various applications...
Rollins B, Martin M, Sequeira P, Moon E, Morgan L, Watson S, et al
. Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS ONE. 2009;4:e4913 pubmed publisher
..Focusing on haplogroup and individual susceptibility factors in psychiatric disorders by considering mtDNA variants may lead to innovative treatments to improve mitochondrial health and brain function...
Kato T, Nishigaki Y, Noguchi Y, Ueno H, Hosoya H, Ito T, et al
. Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. J Hum Genet. 2010;55:147-54 pubmed publisher
..11778G>A in the MT-ND4 gene and 15498G>A in the MT-CYB gene were detected in one patient for each. This screening system is useful for the genetic diagnosis and epidemiological study of both syndromic and non-syndromic HL...