Gene Symbol: COX1
Description: cytochrome c oxidase subunit I
Species: Neandertal

Top Publications

  1. Holinstat M, Boutaud O, Apopa P, Vesci J, Bala M, Oates J, et al. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2? differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol. 2011;31:435-42 pubmed publisher
    ..The concerted evidence indicates that the platelet thrombin receptors signal activation of cPLA(2?) coupled to COX-1 by a pathway different from that signaling activation of the cPLA(2?) coupled to 12-lipoxygenase. ..
  2. Green R, Malaspinas A, Krause J, Briggs A, Johnson P, Uhler C, et al. A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell. 2008;134:416-26 pubmed publisher
    ..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
  3. Tam E, Feigenbaum A, Addis J, Blaser S, Mackay N, Al Dosary M, et al. A novel mitochondrial DNA mutation in COX1 leads to strokes, seizures, and lactic acidosis. Neuropediatrics. 2008;39:328-34 pubmed publisher
    ..Sequencing of mtDNA revealed an heteroplasmic m.7023G>A mutation in the COX1 gene, with levels of 96% in muscle, 70% in blood and 50% in the initial skin fibroblast culture dropping to 10% in ..
  4. Soto I, Fontanesi F, Valledor M, Horn D, Singh R, Barrientos A. Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F1F0-ATP synthase. Biochim Biophys Acta. 2009;1793:1776-86 pubmed publisher
    ..Our findings imply that fully assembled ATPase and its proton pumping function are both required for COX biogenesis in yeast and mammalian cells through a mechanism independent of Cox1p synthesis...
  5. Luo Y, Tang S, Gao W, Chen L, Yang X, Huang T, et al. Genotyping mitochondrial DNA single nucleotide polymorphisms by PCR ligase detection reactions. Clin Chem Lab Med. 2010;48:475-83 pubmed publisher
    ..The PCR-LDR mtDNA genotyping technique is simple, highly accurate, has high-throughput, and is cost-effective. Therefore, this method is applicable to mtDNA haplotyping in various applications...
  6. Ray A, Zuhlke K, Levin A, Douglas J, Cooney K, Petros J. Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men. Prostate. 2009;69:956-60 pubmed publisher
    ..Additional research will be needed to determine the clinical relevance of these associations in African populations...
  7. Alsbeih G, Al Harbi N, El Sebaie M, Al Rajhi N, Al Hadyan K, Abu Amero K. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. Clin Cancer Res. 2009;15:7352-60 pubmed publisher
    ..Predictive markers of radiosensitivity should take into account mtDNA genetic variations in addition to variations in nuclear genes...
  8. Kokotas H, Grigoriadou M, Korres G, Ferekidou E, Kandiloros D, Korres S, et al. Screening of a Greek deafness population for the A7445G mitochondrial DNA mutation. Mol Genet Metab. 2010;100:300-1 pubmed publisher
  9. Lakatos A, Derbeneva O, Younes D, Keator D, Bakken T, Lvova M, et al. Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. Neurobiol Aging. 2010;31:1355-63 pubmed publisher
    ..Our results indicate that the mitochondrial haplogroup UK may confer genetic susceptibility to AD independently of the apolipoprotein E4 (APOE4) allele...

More Information


  1. Hinttala R, Sasarman F, Nishimura T, Antonicka H, Brunel Guitton C, Schwartzentruber J, et al. An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase. Hum Mol Genet. 2015;24:4103-13 pubmed publisher
    ..These results show that mitochondrial protein synthesis can occur with inefficient formylation of methionyl-tRNA(Met), but that assembly of complex IV is impaired if the COXI N-terminus is not formylated. ..
  2. Nishigaki Y, Ueno H, Coku J, Koga Y, Fujii T, Sahashi K, et al. Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations. Mitochondrion. 2010;10:300-8 pubmed publisher
    ..This genetic screening platform is useful to reach a definitive diagnosis for mitochondrial diseases...
  3. Kumar M, Pathak D, Kriplani A, Ammini A, Talwar P, Dada R. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency. Arch Gynecol Obstet. 2010;282:695-705 pubmed publisher
  4. Kapitanović Vidak H, Catela Ivkovic T, Vidak Z, Kapitanovic S. COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants. Mol Neurobiol. 2017;54:930-938 pubmed publisher
  5. Stylos E, Chatziathanasiadou M, Tsiailanis A, Kellici T, Tsoumani M, Kostagianni A, et al. Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation. Biochim Biophys Acta Gen Subj. 2017;1861:2609-2618 pubmed publisher
    ..Natural products could offer a rich source for novel bioactives as a powerful alternative to the current combinatorial use of three different antiplatelet drugs. ..