Gene Symbol: tlyA
Description: 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA
Species: Mycobacterium tuberculosis H37Rv
Wren B, Stabler R, Das S, Butcher P, Mangan J, Clarke J, et al
. Characterization of a haemolysin from Mycobacterium tuberculosis with homology to a virulence factor of Serpulina hyodysenteriae. Microbiology. 1998;144 ( Pt 5):1205-11 pubmed
..a 268-amino-acid polypeptide which is highly similar to a pore-forming haemolysin/cytotoxin virulence determinant, TlyA, from the swine pathogen Serpulina hyodysenteriae...
Georghiou S, Magaña M, Garfein R, Catanzaro D, Catanzaro A, Rodwell T. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review. PLoS ONE. 2012;7:e33275 pubmed publisher
..Mutations in the rrs, tlyA, eis promoter and gidB genes were associated with AMK, KAN and/or CAP resistance...
Du Q, Long Q, Mao J, Fu T, Duan X, Xie J. Characterization of a novel mutation in the overlap of tlyA and ppnK involved in capreomycin resistance in Mycobacterium. IUBMB Life. 2014;66:405-14 pubmed publisher
..We further sequenced the whole genome of C4 and found an A to G substitution in the overlap region between tlyA and ppnK, which leads a stop codon mutation in upstream tlyA and a T2A mutation in downstream ppnK...
Rahman A, Srivastava S, Sneh A, Ahmed N, Krishnasastry M. Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: a non-conventional hemolysin and a ribosomal RNA methyl transferase. BMC Biochem. 2010;11:35 pubmed publisher
..In this study we report the dual functionality of tlyA gene product of Mycobacterium tuberculosis annotated as Rv1694, a 268 amino acid long basic protein.
Witek M, Kuiper E, Minten E, Crispell E, Conn G. A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. J Biol Chem. 2017;292:1977-1987 pubmed publisher
..capreomycin binding and Mtb ribosome inhibition requires ribosomal RNA methylation in both ribosome subunits by TlyA (Rv1694), an enzyme with dual 2'-O-methytransferase and putative hemolytic activities...
Rahman M, Sobia P, Dwivedi V, Bhawsar A, Singh D, Sharma P, et al
. Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis. J Biol Chem. 2015;290:14407-17 pubmed publisher
..tuberculosis have been identified, its pathogenesis remains incompletely understood. TlyA is a virulence factor in several bacterial infections and is evolutionarily conserved in many Gram-positive ..