Gene Symbol: sigB
Description: RNA polymerase sigma factor SigB
Species: Mycobacterium tuberculosis H37Rv
Predich M, Doukhan L, Nair G, Smith I. Characterization of RNA polymerase and two sigma-factor genes from Mycobacterium smegmatis. Mol Microbiol. 1995;15:355-66 pubmed
..We also demonstrated in vitro transcription of the M. smegmatis rrnB promoter by the M. smegmatis RNA polymerase. Significantly, highly active B. subtilis RNA polymerase holoenzyme was unable to transcribe this gene...
He H, Hovey R, Kane J, Singh V, Zahrt T. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J Bacteriol. 2006;188:2134-43 pubmed
..Response regulator MprA bound to conserved motifs in the upstream regions of both sigB and sigE in vitro and regulated the in vivo expression of sigB and sigE in M. tuberculosis...
Beggs M, Cave M, Eisenach K. Isolation and sequence of a Mycobacterium tuberculosis sigma factor. Gene. 1996;174:285-7 pubmed
..The protein encoded by this gene is 92% similar to the Mycobacterium smegmatis sigma factor MysB, and has been designated Mtu SigB. A Mycobacterium leprae homologue of mysB and mtu sigB was identified in the database.
Doukhan L, Predich M, Nair G, Dussurget O, Mandic Mulec I, Cole S, et al
. Genomic organization of the mycobacterial sigma gene cluster. Gene. 1995;165:67-70 pubmed
We have previously described sigma A and sigma B and their structural genes, mysA and mysB, respectively, in Mycobacterium smegmatis. We have now sequenced the corresponding regions in the M. tuberculosis and M...
Fontan P, Voskuil M, Gomez M, Tan D, Pardini M, Manganelli R, et al
. The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth. J Bacteriol. 2009;191:5628-33 pubmed publisher
..In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia...
Song T, Song S, Raman S, Anaya M, Husson R. Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH. J Bacteriol. 2008;190:2227-30 pubmed publisher
Mycobacterial SigE and SigH both initiate transcription from the sigB promoter, suggesting that they recognize similar sequences...