Gene Symbol: PPE68
Description: PPE family protein PPE68
Species: Mycobacterium tuberculosis H37Rv
Mustafa A. Characterization of a cross-reactive, immunodominant and HLA-promiscuous epitope of Mycobacterium tuberculosis-specific major antigenic protein PPE68. PLoS ONE. 2014;9:e103679 pubmed publisher
b>PPE68 (Rv3873), a major antignic protein encoded by Mycobacteriun tuberculosis-specific genomic region of difference (RD)1, is a strong stimulator of peripheral blood mononuclear cells (PBMCs) obtained from tuberculosis patients and ..
Liu X. [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:305-8 pubmed
..9%, 2.6%, and 2.6%, respectively, in the control group. Rv3879c peptides can be candidates for inclusion in new T cell-based tests for MTB infection. ..
Tiwari B, Soory A, Raghunand T. An immunomodulatory role for the Mycobacterium tuberculosis region of difference 1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873). FEBS J. 2014;281:1556-70 pubmed publisher
..Here we investigate the function of the PE-PPE gene pair PE35 (Rv3872)-PPE68 (Rv3873), located in the region of difference 1, encoding a specialized mycobacterial secretion system that is ..
Vasilevsky S, Stojanov M, Greub G, Baud D. Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates. Virulence. 2016;7:11-22 pubmed publisher
..Thus, Pmps might be important not only for the pathogenesis of chlamydial infection, but also as potential candidate vaccine proteins. ..
Danelishvili L, Everman J, Bermudez L. Mycobacterium tuberculosis PPE68 and Rv2626c genes contribute to the host cell necrosis and bacterial escape from macrophages. Virulence. 2016;7:23-32 pubmed publisher
..Two knockout mutants of the Rv3873 gene, encoding a cell wall PPE68 protein of RD1 region, were identified out of 5 NDMs...
Jiang Y, Wei J, Liu H, Li G, Guo Q, Qiu Y, et al
. Polymorphisms in the PE35 and PPE68 antigens in Mycobacterium tuberculosis strains may affect strain virulence and reflect ongoing immune evasion. Mol Med Rep. 2016;13:947-54 pubmed publisher
..It has been previously demonstrated that two PE/PPE proteins, PE35 (Rv3872) and PPE68 (Rv3873), are encoded by RD1 and exhibit immunodominance...