Gene Symbol: pknG
Description: serine/threonine-protein kinase PknG
Species: Mycobacterium tuberculosis H37Rv

Top Publications

  1. Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto Baschong C, Huygen K, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004;304:1800-4 pubmed publisher
  2. Scherr N, Müller P, Perisa D, Combaluzier B, Jeno P, Pieters J. Survival of pathogenic mycobacteria in macrophages is mediated through autophosphorylation of protein kinase G. J Bacteriol. 2009;191:4546-54 pubmed publisher
    ..A crucial factor for avoiding lysosomal degradation is the mycobacterial serine/threonine protein kinase G (PknG)...
  3. Lisa M, Gil M, André Leroux G, Barilone N, Durán R, Biondi R, et al. Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis. Structure. 2015;23:1039-48 pubmed publisher
    ..Here, we focus on the multidomain S/T protein kinase PknG, a soluble enzyme that controls central metabolism in Actinobacteria and has been linked to Mtb infectivity...
  4. Majlessi L, Combaluzier B, Albrecht I, Garcia J, Nouzé C, Pieters J, et al. Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules. J Immunol. 2007;179:1825-33 pubmed
    ..These findings are important in the rational design of improved vaccines to combat mycobacterial diseases. ..
  5. Chaurasiya S, Srivastava K. Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG. BMC Microbiol. 2009;9:271 pubmed publisher
    ..Since PknG is uniquely expressed in BCG, Ra, Rv but not in MS and has been reported to promote intracellular survival of ..
  6. Khan M, Bhaskar A, Upadhyay S, Kumari P, Rajmani R, Jain P, et al. Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions. J Biol Chem. 2017;292:16093-16108 pubmed publisher
    Protein kinase G (PknG), a thioredoxin-fold-containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycobacterium tuberculosis, required for inhibition of phagolysosomal fusion...
  7. Chen D, Ma S, He L, Yuan P, She Z, Lu Y. Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages. Tuberculosis (Edinb). 2017;103:37-43 pubmed publisher
    As a eukaryotic-like Ser/Thr protein kinase, Mycobacterium tuberculosis virulent effector protein kinase G (PknG) mediates mycobacterial survival by regulating bacterial cell metabolic processes and preventing phagosome-lysosome fusion in ..
  8. Scherr N, Honnappa S, Kunz G, Mueller P, Jayachandran R, Winkler F, et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007;104:12151-6 pubmed
    ..A crucial virulence factor for intracellular mycobacterial survival is protein kinase G (PknG), a eukaryotic-like serine/threonine protein kinase expressed by pathogenic mycobacteria that blocks the ..
  9. Wittwer M, Dames S. Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G. Protein Expr Purif. 2015;111:68-74 pubmed publisher
    Mycobacterium tuberculosis protein kinase G (PknG) is secreted into host macrophages to block lysosomal degradation. The catalytic domain (∼147-405) is C-terminally flanked by a tetratricopeptide repeat domain (TPRD)...

More Information


  1. Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar Adler N, et al. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. PLoS Pathog. 2017;13:e1006399 pubmed publisher
    ..Serine/threonine protein kinase G (PknG) is required for virulence of the human pathogen Mycobacterium tuberculosis, and its putative substrate GarA ..