Gene Symbol: ndkA
Description: nucleoside diphosphate kinase
Species: Mycobacterium tuberculosis H37Rv
Sureka K, Sanyal S, Basu J, Kundu M. Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria. Mol Microbiol. 2009;74:1187-97 pubmed publisher
..We present evidence that PPK2 does so by interacting with nucleoside diphosphate kinase (Ndk)...
Chen Y, Morera S, Mocan J, Lascu I, Janin J. X-ray structure of Mycobacterium tuberculosis nucleoside diphosphate kinase. Proteins. 2002;47:556-7 pubmed
Sun J, Singh V, Lau A, Stokes R, Obreg n Henao A, Orme I, et al
. Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. PLoS Pathog. 2013;9:e1003499 pubmed publisher
..Here we applied an antisense strategy to knock down Mtb nucleoside diphosphate kinase (Ndk) and obtained a stable mutant (Mtb Ndk-AS) that displayed attenuated intracellular survival along with reduced ..
Morera S, Lacombe M, Xu Y, Lebras G, Janin J. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution. Structure. 1995;3:1307-14 pubmed
..If NDP kinase B binds DNA in the same way as the polymerases, the enzyme must undergo a conformation change in order to carry out gene activation. ..
Kumar P, Krishna K, Srinivasan R, Ajitkumar P, Varshney U. Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA. DNA Repair (Amst). 2004;3:1483-92 pubmed
..We investigated for the presence of such activities in M. tuberculosis NDK (MtuNDK), which shares 45.2% identity, and 52.6% similarity with EcoNDK...
Georgescauld F, Moynié L, Habersetzer J, Cervoni L, Mocan I, Borza T, et al
. Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis. PLoS ONE. 2013;8:e57867 pubmed publisher
..Indeed, guanidinium and many other salts stabilized the hexamer with a half maximum effect of about 0.1 M, increasing protein thermostability. The crystal structure of the D93N mutant has been solved. ..