Gene Symbol: MSMEG_0060
Description: hypothetical protein
Species: Mycobacterium smegmatis MC2
Converse S, Cox J. A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J Bacteriol. 2005;187:1238-45 pubmed
..M. smegmatis, therefore, represents a powerful system to study the multicomponent Snm secretory machine and to understand the role of this conserved system in mycobacterial biology. ..
Bitter W, Houben E, Bottai D, Brodin P, Brown E, Cox J, et al
. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 2009;5:e1000507 pubmed publisher
Flint J, Kowalski J, Karnati P, Derbyshire K. The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis. Proc Natl Acad Sci U S A. 2004;101:12598-603 pubmed
..smegmatis. Our results indicate that the M. tuberculosis and M. smegmatis RD1 regions are functionally equivalent and provide a unique perspective on the role of this critical secretion apparatus. ..
Zhang X, Li D, Fleming J, Wang L, Zhou Y, Wang D, et al
. Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. FASEB J. 2015;29:4804-14 pubmed publisher
..Our results suggest that EccB may act as the energy provider in the transport of T7SS virulence factors and may be involved in the formation of a channel across the mycomembrane. ..
Wagner J, Chan S, Evans T, Kahng S, Kim J, Arbing M, et al
. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. BMC Struct Biol. 2016;16:5 pubmed publisher
..These structures represent a major step towards resolving the molecular architecture of the entire ESX-1 assembly and may contribute to ESX-1 targeted tuberculosis intervention strategies. ..