Gene Symbol: MSMEG_0060
Description: hypothetical protein
Species: Mycobacterium smegmatis MC2
- Converse S, Cox J. A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J Bacteriol. 2005;187:1238-45 pubmed..M. smegmatis, therefore, represents a powerful system to study the multicomponent Snm secretory machine and to understand the role of this conserved system in mycobacterial biology. ..
- Flint J, Kowalski J, Karnati P, Derbyshire K. The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis. Proc Natl Acad Sci U S A. 2004;101:12598-603 pubmed..smegmatis. Our results indicate that the M. tuberculosis and M. smegmatis RD1 regions are functionally equivalent and provide a unique perspective on the role of this critical secretion apparatus. ..
- Zhang X, Li D, Fleming J, Wang L, Zhou Y, Wang D, et al. Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. FASEB J. 2015;29:4804-14 pubmed publisher..Our results suggest that EccB may act as the energy provider in the transport of T7SS virulence factors and may be involved in the formation of a channel across the mycomembrane. ..
- Wagner J, Chan S, Evans T, Kahng S, Kim J, Arbing M, et al. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. BMC Struct Biol. 2016;16:5 pubmed publisher..These structures represent a major step towards resolving the molecular architecture of the entire ESX-1 assembly and may contribute to ESX-1 targeted tuberculosis intervention strategies. ..