Gene Symbol: mprA
Description: two-component response regulator MrpA
Species: Mycobacterium tuberculosis H37Rv

Top Publications

  1. He H, Hovey R, Kane J, Singh V, Zahrt T. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J Bacteriol. 2006;188:2134-43 pubmed
    ..tuberculosis. With DNA microarrays and quantitative real-time reverse transcription-PCR, genes regulated by MprA in M. tuberculosis that included two stress-responsive sigma factors were identified...
  2. Zahrt T, Wozniak C, Jones D, Trevett A. Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect Immun. 2003;71:6962-70 pubmed
    ..tuberculosis physiology and virulence, a functional analysis of the mprA and mprB gene products was initiated...
  3. Zahrt T, Deretic V. Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc Natl Acad Sci U S A. 2001;98:12706-11 pubmed publisher
    ..Inactivation of this response regulator, Rv0981 (termed here mprA for mycobacterial persistence regulator), affected M...
  4. He H, Zahrt T. Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. J Bacteriol. 2005;187:202-12 pubmed publisher
    ..and maintenance of persistent, latent infection by Mycobacterium tuberculosis are dependent on expression of the mprA-mprB regulatory system...
  5. Pang X, Vu P, Byrd T, Ghanny S, Soteropoulos P, Mukamolova G, et al. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology. 2007;153:1229-42 pubmed
    ..Using a deletion mutant lacking portions of the response regulator, MprA, and the histidine kinase, MprB, it was demonstrated by real-time PCR, primer extension analyses and DNA ..
  6. Bretl D, He H, Demetriadou C, White M, Penoske R, Salzman N, et al. MprA and DosR coregulate a Mycobacterium tuberculosis virulence operon encoding Rv1813c and Rv1812c. Infect Immun. 2012;80:3018-33 pubmed publisher
    ..Here, we describe a previously uncharacterized locus, Rv1813c-Rv1812c, that is coregulated by both MprA and DosR...
  7. Bretl D, Bigley T, Terhune S, Zahrt T. The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. J Bacteriol. 2014;196:391-406 pubmed publisher
    ..Following exposure to cell envelope stress, proteins present in the extracytoplasmic space become unfolded or misfolded, leading to removal of the ECD-mediated negative regulation of MprB and subsequent activation of MprAB. ..
  8. Pang X, Howard S. Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system of Mycobacterium tuberculosis. J Bacteriol. 2007;189:6213-21 pubmed
    ..Electrophoresis mobility shift assays revealed multiple MprA binding sites in the acr2 promoter, including one downstream and three upstream of the acr2 TSP, with one ..
  9. Cao G, Howard S, Zhang P, Wang X, Chen X, Samten B, et al. EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR. Microbiology. 2015;161:477-89 pubmed publisher
    ..In this report, we reveal that EspR is directly regulated by MprA and PhoP-Rv, but not by PhoP-Ra...

More Information


  1. Manganelli R, Voskuil M, Schoolnik G, Smith I. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol Microbiol. 2001;41:423-37 pubmed
    ..These genes encode proteins belonging to different classes including transcriptional regulators, enzymes involved in fatty acid degradation and classical heat shock proteins. ..
  2. He H, Bretl D, Penoske R, Anderson D, Zahrt T. Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis. J Bacteriol. 2011;193:5105-18 pubmed publisher
    ..encoding components of a predicted formate hydrogenylase enzyme complex that is directly regulated by DosR/DevR and MprA, and the product of the first gene in this operon, Rv0081...