Gene Symbol: espJ
Description: ESX-1 secretion-associated protein EspJ
Alias: TB27.4
Species: Mycobacterium tuberculosis H37Rv

Top Publications

  1. Liu X. [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:305-8 pubmed
    ..9%, 2.6%, and 2.6%, respectively, in the control group. Rv3879c peptides can be candidates for inclusion in new T cell-based tests for MTB infection. ..
  2. Jiang Y, Wan L, Zhang Z, Liu H, Pang H, Zhang W, et al. Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms. Tuberculosis (Edinb). 2014;94:245-51 pubmed publisher
    ..tuberculosis strains and there are polymorphisms existing in the protein. The large number of amino acid changes in its T cell epitopes may reflect ongoing immune evasion. ..
  3. Singh P, Saxena R, Tiwari S, Singh D, Singh S, Kumari R, et al. RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria. Sci Rep. 2015;5:12717 pubmed publisher
    ..The present study describes STPK modulated modification in one of the hypothetical proteins of the RD1 region; EspJ (ESX-1 secretion associated protein), which is predicted to be involved in virulence of MTB...
  4. McLaughlin B, Chon J, MacGurn J, Carlsson F, Cheng T, Cox J, et al. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog. 2007;3:e105 pubmed
    ..The results establish EspB as a substrate of ESX-1 that is required for virulence and growth in macrophages and suggests that the contribution of ESX-1 to virulence may arise from the secretion of multiple independent substrates. ..