Gene Symbol: espJ
Description: ESX-1 secretion-associated protein EspJ
Species: Mycobacterium tuberculosis H37Rv
Liu X. [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:305-8 pubmed
..9%, 2.6%, and 2.6%, respectively, in the control group. Rv3879c peptides can be candidates for inclusion in new T cell-based tests for MTB infection. ..
Jiang Y, Wan L, Zhang Z, Liu H, Pang H, Zhang W, et al
. Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms. Tuberculosis (Edinb). 2014;94:245-51 pubmed publisher
..tuberculosis strains and there are polymorphisms existing in the protein. The large number of amino acid changes in its T cell epitopes may reflect ongoing immune evasion. ..
Singh P, Saxena R, Tiwari S, Singh D, Singh S, Kumari R, et al
. RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria. Sci Rep. 2015;5:12717 pubmed publisher
..The present study describes STPK modulated modification in one of the hypothetical proteins of the RD1 region; EspJ (ESX-1 secretion associated protein), which is predicted to be involved in virulence of MTB...
McLaughlin B, Chon J, MacGurn J, Carlsson F, Cheng T, Cox J, et al
. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog. 2007;3:e105 pubmed
..The results establish EspB as a substrate of ESX-1 that is required for virulence and growth in macrophages and suggests that the contribution of ESX-1 to virulence may arise from the secretion of multiple independent substrates. ..