Gene Symbol: eis
Description: enhanced intracellular survival protein
Species: Mycobacterium tuberculosis H37Rv
Products:     eis

Top Publications

  1. Wei J, Dahl J, Moulder J, Roberts E, O Gaora P, Young D, et al. Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages. J Bacteriol. 2000;182:377-84 pubmed
    ..This gene was named the enhanced intracellular survival (eis) gene...
  2. Zaunbrecher M, Sikes R, Metchock B, Shinnick T, Posey J. Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2009;106:20004-9 pubmed publisher
    ..We identified mutations in the -10 and -35 promoter region of the eis gene, which encodes a previously uncharacterized aminoglycoside acetyltransferase...
  3. Chen W, Biswas T, Porter V, Tsodikov O, Garneau Tsodikova S. Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB. Proc Natl Acad Sci U S A. 2011;108:9804-8 pubmed publisher
    ..Here, we reveal the function and structure of the mycobacterial protein Eis responsible for resistance to kanamycin in a significant fraction of kanamycin-resistant Mycobacterium tuberculosis ..
  4. Samuel L, Song C, Wei J, Roberts E, Dahl J, Barry C, et al. Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion. Microbiology. 2007;153:529-40 pubmed
    The eis gene of Mycobacterium tuberculosis has been shown to play a role in the survival of the avirulent Mycobacterium smegmatis within the macrophage...
  5. Shin D, Jeon B, Lee H, Jin H, Yuk J, Song C, et al. Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathog. 2010;6:e1001230 pubmed publisher
    The "enhanced intracellular survival" (eis) gene of Mycobacterium tuberculosis (Mtb) is involved in the intracellular survival of M. smegmatis. However, its exact effects on host cell function remain elusive...
  6. Lella R, Sharma C. Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells. J Biol Chem. 2007;282:18671-5 pubmed
    ..Secretory proteins play a major role in host-pathogen interactions. The eis (Rv2416c) gene has been identified as a secretory protein, and it has been shown that it enhances intracellular ..
  7. Ganaie A, Lella R, Solanki R, Sharma C. Thermostable hexameric form of Eis (Rv2416c) protein of M. tuberculosis plays an important role for enhanced intracellular survival within macrophages. PLoS ONE. 2011;6:e27590 pubmed publisher
    b>Eis protein is reported to enhance the intracellular survival of Mycobacterium tuberculosis in human macrophages...
  8. Kambli P, Ajbani K, Nikam C, Sadani M, Shetty A, Udwadia Z, et al. Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables. Int J Mycobacteriol. 2016;5:1-6 pubmed publisher
    ..Thus, the aim of our study was to correlate rrs (X52917) and eis (AF144099) promoter mutations, found in M...
  9. Georghiou S, MagaƱa M, Garfein R, Catanzaro D, Catanzaro A, Rodwell T. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review. PLoS ONE. 2012;7:e33275 pubmed publisher
    ..Mutations in the rrs, tlyA, eis promoter and gidB genes were associated with AMK, KAN and/or CAP resistance...

More Information


  1. Maurya V, Singh K, Sinha S. Suppression of Eis and expression of Wag31 and GroES in Mycobacterium tuberculosis cytosol under anaerobic culture conditions. Indian J Exp Biol. 2014;52:773-80 pubmed
    ..these proteins was highly suppressed (>2 fold reduction in spot volumes), with 4 of them (GrpE, CanB, MoxR1 and Eis) appearing as completely suppressed since corresponding spots were not detectable in the anaerobic sample...
  2. Kim K, An D, Song J, Yoon J, Kim H, Yoon H, et al. Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7. Proc Natl Acad Sci U S A. 2012;109:7729-34 pubmed publisher
    The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in macrophages...
  3. Duan L, Yi M, Chen J, Li S, Chen W. Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3. Biochem Biophys Res Commun. 2016;473:1229-1234 pubmed publisher
    ..Recently, MTB enhanced intracellular survival (EIS) protein was reported to be secreted from MTB cells and linked to the inhibition of autophagy and the intracellular ..
  4. Pholwat S, Stroup S, Heysell S, Ogarkov O, Zhdanova S, Ramakrishnan G, et al. eis Promoter C14G and C15G Mutations Do Not Confer Kanamycin Resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2016;60:7522-7523 pubmed
    We studied the significance of particular eis mutations on Mycobacterium tuberculosis drug resistance using a specialized transduction strategy...
  5. Gikalo M, Nosova E, Krylova L, Moroz A. The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region. J Antimicrob Chemother. 2012;67:2107-9 pubmed publisher
    ..In the present study we evaluated the incidence of eis mutations in kanamycin-resistant Mycobacterium tuberculosis isolates. ..