eccA1

Summary

Gene Symbol: eccA1
Description: ESX-1 secretion system protein EccA1
Species: Mycobacterium tuberculosis H37Rv
Products:     eccA1

Top Publications

  1. Champion P, Champion M, Manzanillo P, Cox J. ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria. Mol Microbiol. 2009;73:950-62 pubmed publisher
    ..Ultimately, understanding the details of ESX-1 targeting may allow for engineering of better vaccines to prevent tuberculosis. ..
  2. McLaughlin B, Chon J, MacGurn J, Carlsson F, Cheng T, Cox J, et al. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog. 2007;3:e105 pubmed
    ..The results establish EspB as a substrate of ESX-1 that is required for virulence and growth in macrophages and suggests that the contribution of ESX-1 to virulence may arise from the secretion of multiple independent substrates. ..