Gene Symbol: S
Description: spike glycoprotein
Alias: spike glycoprotein, E2 glycoprotein precursor
Species: Murine hepatitis virus
Navas Martin S, Hingley S, Weiss S. Murine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein. J Virol. 2005;79:7629-40 pubmed publisher
..compelling evidence of the ability of coronaviruses to rapidly evolve in vivo to highly virulent phenotypes by functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein.
McRoy W, Baric R. Amino acid substitutions in the S2 subunit of mouse hepatitis virus variant V51 encode determinants of host range expansion. J Virol. 2008;82:1414-24 pubmed publisher
..b>S. Baric, E. Sullivan, L. Hensley, B. Yount, and W. Chen, J. Virol. 73:638-649, 1999)...
Langereis M, van Vliet A, Boot W, de Groot R. Attachment of mouse hepatitis virus to O-acetylated sialic acid is mediated by hemagglutinin-esterase and not by the spike protein. J Virol. 2010;84:8970-4 pubmed publisher
..of Betacoronavirus phylocluster A possess two types of surface projections, one comprised of the spike protein (S) and the other of hemagglutinin-esterase (HE)...
de Haan C, te Lintelo E, Li Z, Raaben M, Wurdinger T, Bosch B, et al
. Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range. J Virol. 2006;80:10909-18 pubmed publisher
To study the process of spike (S)-receptor interaction during coronavirus entry, we evaluated the contributions of mutations in different regions of the murine hepatitis virus (MHV) S protein to natural receptor murine carcinoembryonic ..
Yao Q, Masters P, Ye R. Negatively charged residues in the endodomain are critical for specific assembly of spike protein into murine coronavirus. Virology. 2013;442:74-81 pubmed publisher
Coronavirus spike (S) protein assembles into virions via its carboxy-terminus, which is composed of a transmembrane domain and an endodomain...
Wicht O, Burkard C, de Haan C, van Kuppeveld F, Rottier P, Bosch B. Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell. J Virol. 2014;88:4943-52 pubmed publisher
..Proteolytic processing of coronavirus spike (S) fusion proteins during virus entry has been suggested but not yet formally demonstrated, while the nature and ..
Leparc Goffart I, Hingley S, Chua M, Jiang X, Lavi E, Weiss S. Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein. Virology. 1997;239:1-10 pubmed publisher
Walls A, Tortorici M, Bosch B, Frenz B, Rottier P, DiMaio F, et al
. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature. 2016;531:114-117 pubmed publisher
..Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer carrying receptor-binding and membrane fusion functions...
Liu Y, Herbst W, Cao J, Zhang X. Deficient incorporation of spike protein into virions contributes to the lack of infectivity following establishment of a persistent, non-productive infection in oligodendroglial cell culture by murine coronavirus. Virology. 2011;409:121-31 pubmed publisher
..Thus, establishment of such a culture system that can recapitulate the in vivo phenomenon will provide a powerful approach for elucidating the mechanisms of coronavirus persistence in glial cells at the cellular and molecular levels. ..