mppA

Summary

Gene Symbol: mppA
Description: murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit
Alias: ECK1326, JW1322, ynaH
Species:

Top Publications

  1. ncbi Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium
    S R Pearce
    Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, UK
    Mol Microbiol 6:47-57. 1992
  2. ncbi The housekeeping dipeptide permease is the Escherichia coli heme transporter and functions with two optional peptide binding proteins
    Sylvie Létoffé
    Unité des Membranes Bactériennes, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2172, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 103:12891-6. 2006
  3. ncbi Identification of the CRP regulon using in vitro and in vivo transcriptional profiling
    Dongling Zheng
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Nucleic Acids Res 32:5874-93. 2004
  4. ncbi DNA microarray analyses of the long-term adaptive response of Escherichia coli to acetate and propionate
    T Polen
    Forschungszentrum Julich, Institut für Biotechnologie I, 52425 Julich, Germany
    Appl Environ Microbiol 69:1759-74. 2003
  5. ncbi The periplasmic protein MppA requires an additional mutated locus to repress marA expression in Escherichia coli
    Xiaowen Bina
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 185:1465-9. 2003
  6. ncbi The periplasmic murein peptide-binding protein MppA is a negative regulator of multiple antibiotic resistance in Escherichia coli
    H Li
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 181:4842-7. 1999
  7. ncbi MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate
    J T Park
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    J Bacteriol 180:1215-23. 1998
  8. ncbi Effects of intracerebroventricular administration of atrial natriuretic peptide on subcortical EEG activity in conscious rabbits
    N Angelopoulos
    Department of Experimental Physiology, Faculty of Medicine, Aristotelion University of Thessaloniki, Greece
    Exp Brain Res 108:427-32. 1996
  9. ncbi Turnover and recycling of the murein sacculus in oligopeptide permease-negative strains of Escherichia coli: indirect evidence for an alternative permease system and for a monolayered sacculus
    J T Park
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111
    J Bacteriol 175:7-11. 1993
  10. ncbi Locations of the opp and supX genes of Salmonella typhimurium and Escherichia coli
    A B Lenny
    J Bacteriol 143:747-52. 1980

Research Grants

  1. MUROPEPTIDE RECYCLING PATHWAY & BETA LACTAMASE INDUCTION
    James Park; Fiscal Year: 2002
  2. MUROPEPTIDE RECYCLING PATHWAY & BETA LACTAMASE INDUCTION
    James Park; Fiscal Year: 2006

Scientific Experts

  • James Park
  • Sylvie Létoffé
  • Dongling Zheng
  • T Polen
  • Xiaowen Bina
  • H Li
  • Philippe Delepelaire
  • Cécile Wandersman
  • Jon L Hobman
  • Stephen D Minchin
  • Chrystala Constantinidou
  • V F Wendisch
  • H Sahm
  • D Rittmann
  • Stuart B Levy
  • Vincent Perreten
  • N Angelopoulos
  • C F Higgins
  • C Kallaras
  • M Apostolakis
  • S R Pearce
  • M P Gallagher
  • I D Hiles
  • D J Jamieson
  • U Gileadi
  • M L Mimmack
  • S C Hyde
  • A B Lenny
  • E W Goodell
  • C A Guyer
  • D G Morgan
  • J V Staros
  • P Margolin
  • K Whalley

Detail Information

Publications15

  1. ncbi Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium
    S R Pearce
    Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, UK
    Mol Microbiol 6:47-57. 1992
    ..These findings, therefore, have general implications for the organization and function of other ABC transporters, including the human multidrug resistance protein and the product of the cystic fibrosis gene...
  2. ncbi The housekeeping dipeptide permease is the Escherichia coli heme transporter and functions with two optional peptide binding proteins
    Sylvie Létoffé
    Unité des Membranes Bactériennes, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2172, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 103:12891-6. 2006
    ..dipeptide inner membrane ATP-binding cassette transporter (DppBCDF) and either of two periplasmic binding proteins: MppA, the L-alanyl-gamma-D-glutamyl-meso-diaminopimelate binding protein, or DppA, the dipeptide binding protein...
  3. ncbi Identification of the CRP regulon using in vitro and in vivo transcriptional profiling
    Dongling Zheng
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Nucleic Acids Res 32:5874-93. 2004
    ..coli. ROMA has revealed 152 hitherto unknown CRP regulons...
  4. ncbi DNA microarray analyses of the long-term adaptive response of Escherichia coli to acetate and propionate
    T Polen
    Forschungszentrum Julich, Institut für Biotechnologie I, 52425 Julich, Germany
    Appl Environ Microbiol 69:1759-74. 2003
    ..The gene expression changes after adaptation to acetate or propionate were not caused solely by uncoupling or osmotic effects but represented specific characteristics of the long-term response of E. coli to either compound...
  5. ncbi The periplasmic protein MppA requires an additional mutated locus to repress marA expression in Escherichia coli
    Xiaowen Bina
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 185:1465-9. 2003
    ..strain TP985, which has an insertional mutation in the gene for the periplasmic murein tripeptide binding protein MppA, was previously reported to overproduce MarA and exhibit a multiple-antibiotic resistance (Mar) phenotype (H...
  6. ncbi The periplasmic murein peptide-binding protein MppA is a negative regulator of multiple antibiotic resistance in Escherichia coli
    H Li
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 181:4842-7. 1999
    b>MppA is a periplasmic binding protein in Escherichia coli essential for uptake of the cell wall murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. We have found serendipitously that E...
  7. ncbi MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate
    J T Park
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    J Bacteriol 180:1215-23. 1998
    ..one such mutant, which is oligopeptide permease (Opp) positive, we have identified a new gene product, designated MppA (murein peptide permease A), that is about 46% identical to OppA, the periplasmic binding protein for Opp...
  8. ncbi Effects of intracerebroventricular administration of atrial natriuretic peptide on subcortical EEG activity in conscious rabbits
    N Angelopoulos
    Department of Experimental Physiology, Faculty of Medicine, Aristotelion University of Thessaloniki, Greece
    Exp Brain Res 108:427-32. 1996
    ..Mean EEG energy changes caused by ANP would reflect its various (mainly inhibitory) effects on the electrical activity recorded from PVN and SON neurons in in vitro and in vivo studies...
  9. ncbi Turnover and recycling of the murein sacculus in oligopeptide permease-negative strains of Escherichia coli: indirect evidence for an alternative permease system and for a monolayered sacculus
    J T Park
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111
    J Bacteriol 175:7-11. 1993
    ..Tripeptides were being released by turnover at a rate of about 50% per generation and then were efficiently recycled. This suggests that in addition to opp, a low-affinity uptake system for tripeptide derived from the sacculus may exist...
  10. ncbi Locations of the opp and supX genes of Salmonella typhimurium and Escherichia coli
    A B Lenny
    J Bacteriol 143:747-52. 1980
    ..These results differ from a previously reported location of the opp gene on the E. coli chromosome. Evidence indicates that the opp gene lies between chr(tonB) and galU in S. typhimurium...
  11. ncbi Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems
    C F Higgins
    EMBO J 4:1033-9. 1985
    ..The hisP, malK and oppD proteins are thus responsible for energy-coupling to their respective transport systems...
  12. ncbi Binding specificity of the periplasmic oligopeptide-binding protein from Escherichia coli
    C A Guyer
    J Bacteriol 168:775-9. 1986
    ..Fluorescence emission data suggested that this periplasmic protein possesses more than one substrate-binding site capable of distinguishing peptides on the basis of amino acyl side chains...
  13. ncbi Uptake of cell wall peptides by Salmonella typhimurium and Escherichia coli
    E W Goodell
    J Bacteriol 169:3861-5. 1987
    ..Our data indicate that the periplasmic oligopeptide-binding protein has more than one substrate-binding site, each with different though overlapping specificities...
  14. ncbi Molecular characterization of the oligopeptide permease of Salmonella typhimurium
    I D Hiles
    Department of Biochemistry, University of Dundee, Scotland
    J Mol Biol 195:125-42. 1987
    ..A detailed comparison of the Opp components with those of other binding protein-dependent transport systems provides insight into the mechanisms and evolution of these transport systems...
  15. ncbi How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan)
    James T Park
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Microbiol Mol Biol Rev 72:211-27, table of contents. 2008
    ..The discovery and properties of the individual proteins and the pathways involved are presented. In addition, the possible role of various peptidoglycan degradation products in the induction of beta-lactamase is discussed...

Research Grants9

  1. MUROPEPTIDE RECYCLING PATHWAY & BETA LACTAMASE INDUCTION
    James Park; Fiscal Year: 2002
    ..The MppA permease pathway for import of free murein tripeptide affects multidrug resistance so that a full understanding of ..
  2. MUROPEPTIDE RECYCLING PATHWAY & BETA LACTAMASE INDUCTION
    James Park; Fiscal Year: 2006
    ....