Gene Symbol: Zscan4c
Description: zinc finger and SCAN domain containing 4C
Alias: Gm397, XM_142517, Zscan4d, zinc finger and SCAN domain containing protein 4C
Falco G, Lee S, Stanghellini I, Bassey U, Hamatani T, Ko M. Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev Biol. 2007;307:539-50 pubmed
..Among the six expressed genes named Zscan4a-Zscan4f, three - Zscan4c, Zscan4d, and Zscan4f - encode full-length ORFs with 506 amino acids...
Storm M, Kumpfmueller B, Thompson B, Kolde R, Vilo J, Hummel O, et al
. Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency. Stem Cells. 2009;27:764-75 pubmed publisher
..Further gain-of-function analyses demonstrate the importance of Zscan4c in regulation of ES cell pluripotency.
Zalzman M, Falco G, Sharova L, Nishiyama A, Thomas M, Lee S, et al
. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature. 2010;464:858-63 pubmed publisher
..Together, our data show a unique mode of genome maintenance in ES cells. ..
Fujii S, Nishikawa Torikai S, Futatsugi Y, Toyooka Y, Yamane M, Ohtsuka S, et al
. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. Sci Rep. 2015;5:9146 pubmed publisher
..However, they proliferated slowly with over-expression of 2-cell stage specific transcripts including Zscan4c, which is known to be involved in telomere elongation in ES cells...
Ishiguro K, Nakatake Y, Chikazawa Nohtomi N, Kimura H, Akiyama T, Oda M, et al
. Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos. In Vitro Cell Dev Biol Anim. 2017;53:179-190 pubmed publisher
..mouse Zscan4 genomic cluster, previous analyses have been done using exogenous transgenes under the regulation of Zscan4c promoter...
Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, et al
. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014;29:7-19 pubmed publisher
..Mechanistically, Rif1 interacts and stabilizes H3K9 methylation complex. Thus, Rif1 regulates telomere length homeostasis of ESCs by mediating heterochromatic silencing. ..
Akiyama T, Xin L, Oda M, Sharov A, Amano M, Piao Y, et al
. Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells. DNA Res. 2015;22:307-18 pubmed publisher
..This heterochromatin-based transcriptional activity suggests that mESCs may maintain their extraordinary genome stability at least in part by transiently resetting their heterochromatin. ..
Eckersley Maslin M, Svensson V, Krueger C, Stubbs T, Giehr P, Krueger F, et al
. MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs. Cell Rep. 2016;17:179-192 pubmed publisher
..While methylation levels were restored once cells exit this state, genomic imprints remained hypomethylated, demonstrating a potential global and enduring influence of endogenous retroviral activation on the epigenome. ..
Nakai Futatsugi Y, Niwa H. Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells. Stem Cell Reports. 2016;6:483-495 pubmed publisher
..Rex1 and Zscan4 did not show any correlation. Taken together, we propose that Zscan4 is activated to recover shortened telomeres during extended cell cycles, irrespective of the pluripotent status. ..