Gene Symbol: Zscan10
Description: zinc finger and SCAN domain containing 10
Alias: BC068284, Zfp206, Zkscan10, Znf206, zinc finger and SCAN domain-containing protein 10, zinc finger and SCAN domains 10, zinc finger protein 206, zinc finger with KRAB and SCAN domains 10
Species: mouse
Products:     Zscan10

Top Publications

  1. Zhang W, Walker E, Tamplin O, Rossant J, Stanford W, Hughes T. Zfp206 regulates ES cell gene expression and differentiation. Nucleic Acids Res. 2006;34:4780-90 pubmed
    ..Expression surveys suggest that the putative SCAN-Zinc finger transcription factor Zfp206 is expressed specifically in ES cells [Zhang,W., Morris,Q.D., Chang,R., Shai,O., Bakowski,M.A., Mitsakakis,N...
  2. Wang Z, Kueh J, Teh C, Rossbach M, Lim L, Li P, et al. Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells. Stem Cells. 2007;25:2173-82 pubmed
    b>Zfp206 (ZNF206 in human) encodes a zinc finger- and SCAN domain-containing protein that is highly expressed in pluripotent ESC. Upon differentiation of human and mouse ESC, Zfp206 expression is quickly repressed...
  3. Yu H, Kunarso G, Hong F, Stanton L. Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem. 2009;284:31327-35 pubmed publisher
    Zfp206 (recently renamed Zscan10) encodes a zinc finger transcription factor specifically expressed in human and mouse embryonic stem cells (ESC)...
  4. Liang Y, Huimei Hong F, Ganesan P, Jiang S, Jauch R, Stanton L, et al. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206. Nucleic Acids Res. 2012;40:8721-32 pubmed
    Zfp206 (also named as Zscan10) belongs to the subfamily of C(2)H(2) zinc finger transcription factors, which is characterized by the N-terminal SCAN domain...
  5. Pettitt S, Liang Q, Rairdan X, Moran J, Prosser H, Beier D, et al. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods. 2009;6:493-5 pubmed publisher
    ..These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background. ..
  6. Liang Y, Choo S, Rossbach M, Baburajendran N, Palasingam P, Kolatkar P. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:443-7 pubmed publisher
    Zfp206 (also named Zscan10) is a transcription factor that plays an important role in maintaining the pluripotent state of embryonic stem cells. Zfp206 is a member of the SCAN-domain family of C(2)H(2) zinc-finger transcription factors...
  7. Kraus P, V S, Yu H, Xing X, Lim S, Adler T, et al. Pleiotropic functions for transcription factor zscan10. PLoS ONE. 2014;9:e104568 pubmed publisher
    The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays...
  8. Yamane M, Fujii S, Ohtsuka S, Niwa H. Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells. Biochem Biophys Res Commun. 2015;468:826-31 pubmed publisher
    Zinc finger and SCAN domain-containing 10 (Zscan10, also known as Zfp206) encodes a transcription factor that has been reported to be involved in the maintenance of pluripotency in mouse embryonic stem (ES) cells...
  9. Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, et al. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Nat Cell Biol. 2017;19:1037-1048 pubmed publisher
    ..We found that the pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) ..